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Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital

Introduction: Proton pump inhibitors (PPIs) are one of the commonest drug prescribed, however it is not without risk of adverse effects especially if the usage is inappropriate. We aimed to evaluate the frequency, indications and appropriateness of PPIs prescription among the medical inpatients, Ser...

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Main Authors: Then, Ru Fah, Tan, Yi Jun, Yan, Pan, Chieng, Jin Yu
Format: Article
Language:English
Published: Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre 2019
Online Access:http://psasir.upm.edu.my/id/eprint/15340/1/Appropriateness%20of%20proton%20pump%20inhibitors%20prescription%20in%20patients%20admitted%20to%20a%20Malaysian%20tertiary%20hospital.pdf
http://psasir.upm.edu.my/id/eprint/15340/
http://spaj.ukm.my/ijphr/index.php/ijphr/article/view/226
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spelling my.upm.eprints.153402019-07-08T07:28:44Z http://psasir.upm.edu.my/id/eprint/15340/ Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital Then, Ru Fah Tan, Yi Jun Yan, Pan Chieng, Jin Yu Introduction: Proton pump inhibitors (PPIs) are one of the commonest drug prescribed, however it is not without risk of adverse effects especially if the usage is inappropriate. We aimed to evaluate the frequency, indications and appropriateness of PPIs prescription among the medical inpatients, Serdang Hospital, which is a tertiary hospital in Malaysia. Materials and Methods:: This is a retrospective cross sectional study consisting of 4953 patients admitted to medical ward from 1st July 2016 to 31st March 2017, and their database were further analysed by Statistical Package for the Social Sciences for Windows (IBM SPSS Statistics 17.0). Unpaired t-test was performed to analyze the data collected. P < 0.05 (two-tailed) is considered significant. Their indications were cross-referenced against the indications adapted from the United States Food and Drug Administration (FDA). Results: 23.9% (1184/4953) of inpatients were using PPIs, and 63% (746/1184) of them recently started on PPI in the ward, with mean age of 59.7 years. More male patients were commenced on PPIs during hospitalization (P value < 0.05). Based on the FDA guideline, only 21.8% patients were indicated, 32.2% were borderline indicated, and 46.0% patients were not indicated in prescribing PPIs. Stress ulcer prophylaxis was the commonest indication, while anaemia with no evidence of gastrointestinal bleed was the main non-indication in starting PPIs. Only 11% of patients had performed the oesophago-gastro-duodenoscopy (OGDS) during the hospital stay. Conclusion: A majority of inpatients were inappropriately prescribed PPIs according to FDA guideline. More efforts should be initiated to improve the current situation of PPIs overutilization in Malaysia. Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/15340/1/Appropriateness%20of%20proton%20pump%20inhibitors%20prescription%20in%20patients%20admitted%20to%20a%20Malaysian%20tertiary%20hospital.pdf Then, Ru Fah and Tan, Yi Jun and Yan, Pan and Chieng, Jin Yu (2019) Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital. International Journal of Public Health Research, 9 (1). pp. 1043-1050. ISSN 2232-0245 http://spaj.ukm.my/ijphr/index.php/ijphr/article/view/226
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Proton pump inhibitors (PPIs) are one of the commonest drug prescribed, however it is not without risk of adverse effects especially if the usage is inappropriate. We aimed to evaluate the frequency, indications and appropriateness of PPIs prescription among the medical inpatients, Serdang Hospital, which is a tertiary hospital in Malaysia. Materials and Methods:: This is a retrospective cross sectional study consisting of 4953 patients admitted to medical ward from 1st July 2016 to 31st March 2017, and their database were further analysed by Statistical Package for the Social Sciences for Windows (IBM SPSS Statistics 17.0). Unpaired t-test was performed to analyze the data collected. P < 0.05 (two-tailed) is considered significant. Their indications were cross-referenced against the indications adapted from the United States Food and Drug Administration (FDA). Results: 23.9% (1184/4953) of inpatients were using PPIs, and 63% (746/1184) of them recently started on PPI in the ward, with mean age of 59.7 years. More male patients were commenced on PPIs during hospitalization (P value < 0.05). Based on the FDA guideline, only 21.8% patients were indicated, 32.2% were borderline indicated, and 46.0% patients were not indicated in prescribing PPIs. Stress ulcer prophylaxis was the commonest indication, while anaemia with no evidence of gastrointestinal bleed was the main non-indication in starting PPIs. Only 11% of patients had performed the oesophago-gastro-duodenoscopy (OGDS) during the hospital stay. Conclusion: A majority of inpatients were inappropriately prescribed PPIs according to FDA guideline. More efforts should be initiated to improve the current situation of PPIs overutilization in Malaysia.
format Article
author Then, Ru Fah
Tan, Yi Jun
Yan, Pan
Chieng, Jin Yu
spellingShingle Then, Ru Fah
Tan, Yi Jun
Yan, Pan
Chieng, Jin Yu
Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
author_facet Then, Ru Fah
Tan, Yi Jun
Yan, Pan
Chieng, Jin Yu
author_sort Then, Ru Fah
title Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
title_short Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
title_full Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
title_fullStr Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
title_full_unstemmed Appropriateness of proton pump inhibitors prescription in patients admitted to a Malaysian tertiary hospital
title_sort appropriateness of proton pump inhibitors prescription in patients admitted to a malaysian tertiary hospital
publisher Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/15340/1/Appropriateness%20of%20proton%20pump%20inhibitors%20prescription%20in%20patients%20admitted%20to%20a%20Malaysian%20tertiary%20hospital.pdf
http://psasir.upm.edu.my/id/eprint/15340/
http://spaj.ukm.my/ijphr/index.php/ijphr/article/view/226
_version_ 1643825905040097280
score 13.211869

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