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In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.

To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibit...

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Main Authors: Khalid, Syamimi, Shaik Mossadeq, Wan Mastura, Daud , Ahmad Israf, Hashim, Puziah, Rejab, S., Shaberi, A.M., Mohamad, Azam Shah, Zakaria, Zainul Amiruddin, Sulaiman, Mohd Roslan
Format: Article
Language:English
English
Published: Karger: Open Access Journals 2010
Online Access:http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf
http://psasir.upm.edu.my/id/eprint/15172/
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spelling my.upm.eprints.151722015-09-22T07:41:56Z http://psasir.upm.edu.my/id/eprint/15172/ In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Khalid, Syamimi Shaik Mossadeq, Wan Mastura Daud , Ahmad Israf Hashim, Puziah Rejab, S. Shaberi, A.M. Mohamad, Azam Shah Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism. Karger: Open Access Journals 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf Khalid, Syamimi and Shaik Mossadeq, Wan Mastura and Daud , Ahmad Israf and Hashim, Puziah and Rejab, S. and Shaberi, A.M. and Mohamad, Azam Shah and Zakaria, Zainul Amiruddin and Sulaiman, Mohd Roslan (2010) In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Medical Principles and Practice, 19 (4). pp. 255-259. ISSN 1011-7571; ESSN:1423-0151 10.1159/000312710 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism.
format Article
author Khalid, Syamimi
Shaik Mossadeq, Wan Mastura
Daud , Ahmad Israf
Hashim, Puziah
Rejab, S.
Shaberi, A.M.
Mohamad, Azam Shah
Zakaria, Zainul Amiruddin
Sulaiman, Mohd Roslan
spellingShingle Khalid, Syamimi
Shaik Mossadeq, Wan Mastura
Daud , Ahmad Israf
Hashim, Puziah
Rejab, S.
Shaberi, A.M.
Mohamad, Azam Shah
Zakaria, Zainul Amiruddin
Sulaiman, Mohd Roslan
In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
author_facet Khalid, Syamimi
Shaik Mossadeq, Wan Mastura
Daud , Ahmad Israf
Hashim, Puziah
Rejab, S.
Shaberi, A.M.
Mohamad, Azam Shah
Zakaria, Zainul Amiruddin
Sulaiman, Mohd Roslan
author_sort Khalid, Syamimi
title In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
title_short In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
title_full In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
title_fullStr In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
title_full_unstemmed In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
title_sort in vivo analgesic effect of aqueous extract of tamarindus indica l. fruits.
publisher Karger: Open Access Journals
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf
http://psasir.upm.edu.my/id/eprint/15172/
_version_ 1643825855164579840
score 13.211869

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