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In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.

Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA...

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Main Authors: Neela, Vasantha Kumari, Sasikumar, M., Ghaznavi, G. R., Sekawi, Zamberi, Nor Shamsudin, Mariana
Format: Article
Language:English
English
Published: Seameo Regional Tropical Medicine & Public Health 2008
Online Access:http://psasir.upm.edu.my/id/eprint/15153/1/In%20vitro%20activities%20of%2028%20antimicrobial%20agents%20against%20methicillin.pdf
http://psasir.upm.edu.my/id/eprint/15153/
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spelling my.upm.eprints.151532015-12-22T04:39:23Z http://psasir.upm.edu.my/id/eprint/15153/ In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia. Neela, Vasantha Kumari Sasikumar, M. Ghaznavi, G. R. Sekawi, Zamberi Nor Shamsudin, Mariana Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA isolates to various classes of antibiotics and to identify the most potent antibiotics, thirty-two clinical isolates comprised of hospital acquired (HA) and community acquired (CA) infections were investigated by disk diffusion test. Of the 32 MRSA isolates, 14 (43.75%) and 18 (56.25%) were community and hospital acquired MRSA, respectively. All isolates were multiple drug resistant to more than 3 classes of antibiotics despite the source or specimen from which it was isolated. The oxacillin MICs for all isolates ranged from 2 to ≥ 256 μg/ml. Twenty-five of 26 erythromycin-resistant MRSA isolates exhibited an inducible MLSB resistance phenotype while one showed an MS phenotype. More than half the isolates (68.75%) were resistant to at least one of the six aminoglycosides tested, with netilmicin as the most susceptible. The most effective antistaphylococcal agents were linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin exhibited 100% susceptibility. Since MRSA is under continuous pressure of acquiring multiple drug resistance, it is imperative to focus routine surveillance on HA and CA-MRSA strains to monitor and limit the spread of this organism. Seameo Regional Tropical Medicine & Public Health 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15153/1/In%20vitro%20activities%20of%2028%20antimicrobial%20agents%20against%20methicillin.pdf Neela, Vasantha Kumari and Sasikumar, M. and Ghaznavi, G. R. and Sekawi, Zamberi and Nor Shamsudin, Mariana (2008) In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia. Southeast Asian Journal of Tropical Medicine and Public Health, 39 (5). pp. 885-892. ISSN 0125-1562 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Methicillin-resistant Staphylococcus aureus (MRSA), an established nosocomial and emerging community pathogen associated with many fatalities due to its hyper-virulence and multiple drug resistant properties, is on the continuous rise. To update the current status on the susceptibility of local MRSA isolates to various classes of antibiotics and to identify the most potent antibiotics, thirty-two clinical isolates comprised of hospital acquired (HA) and community acquired (CA) infections were investigated by disk diffusion test. Of the 32 MRSA isolates, 14 (43.75%) and 18 (56.25%) were community and hospital acquired MRSA, respectively. All isolates were multiple drug resistant to more than 3 classes of antibiotics despite the source or specimen from which it was isolated. The oxacillin MICs for all isolates ranged from 2 to ≥ 256 μg/ml. Twenty-five of 26 erythromycin-resistant MRSA isolates exhibited an inducible MLSB resistance phenotype while one showed an MS phenotype. More than half the isolates (68.75%) were resistant to at least one of the six aminoglycosides tested, with netilmicin as the most susceptible. The most effective antistaphylococcal agents were linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin exhibited 100% susceptibility. Since MRSA is under continuous pressure of acquiring multiple drug resistance, it is imperative to focus routine surveillance on HA and CA-MRSA strains to monitor and limit the spread of this organism.
format Article
author Neela, Vasantha Kumari
Sasikumar, M.
Ghaznavi, G. R.
Sekawi, Zamberi
Nor Shamsudin, Mariana
spellingShingle Neela, Vasantha Kumari
Sasikumar, M.
Ghaznavi, G. R.
Sekawi, Zamberi
Nor Shamsudin, Mariana
In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.
author_facet Neela, Vasantha Kumari
Sasikumar, M.
Ghaznavi, G. R.
Sekawi, Zamberi
Nor Shamsudin, Mariana
author_sort Neela, Vasantha Kumari
title In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.
title_short In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.
title_full In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.
title_fullStr In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.
title_full_unstemmed In vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (MRSA) from a clinical setting in Malaysia.
title_sort in vitro activities of 28 antimicrobial agents against methicillin-resistant staphylococcus aureus (mrsa) from a clinical setting in malaysia.
publisher Seameo Regional Tropical Medicine & Public Health
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/15153/1/In%20vitro%20activities%20of%2028%20antimicrobial%20agents%20against%20methicillin.pdf
http://psasir.upm.edu.my/id/eprint/15153/
_version_ 1643825849776996352
score 13.222552

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