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Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity

This study is conducted to investigate the possible effect of zerumbone towards hepatoprotective activity against paracetamol intoxication. Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals. Group I was administered with 0.2% zerumbone for 14 days prior to 3 g k...

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Main Authors: Fakurazi, Sharida, Ithnin, Hairuszah, Jabit, Mohd Lip, Ganabadi, Shanti, Nanthini, Uma, Abdul Rahman, Shamima, Abd Hamid @ Abdul Razak, Roslida, Tan, Y. H.
Format: Article
Language:English
Published: Asian Network for Scientific Information 2009
Online Access:http://psasir.upm.edu.my/id/eprint/14996/1/Hepatoprotective%20action%20of%20zerumbone%20against%20paracetamol%20induced%20hepatotoxicity.pdf
http://psasir.upm.edu.my/id/eprint/14996/
http://www.scialert.net/abstract/?doi=jms.2009.161.164
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spelling my.upm.eprints.149962016-10-28T02:19:46Z http://psasir.upm.edu.my/id/eprint/14996/ Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity Fakurazi, Sharida Ithnin, Hairuszah Jabit, Mohd Lip Ganabadi, Shanti Nanthini, Uma Abdul Rahman, Shamima Abd Hamid @ Abdul Razak, Roslida Tan, Y. H. This study is conducted to investigate the possible effect of zerumbone towards hepatoprotective activity against paracetamol intoxication. Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals. Group I was administered with 0.2% zerumbone for 14 days prior to 3 g kg-1 paracetamol administration. Group II was given paracetamol early and group III was given 200 mg kg-1 of silymarin and paracetamol. Group IV was administered with zerumbone only and finally group V was treated with corn oil and 40% sucrose buffer as vehicle treated group. Animals were sacrificed at 4 and 24 h post treatment following diethyl ether. There was no significant changes in liver enzyme activities as well as histological observations at 4 h after paracetamol administration. Meanwhile, 24 h after paracetamol administration, the level of alanine aminotransferase (ALT), aspartate aminotransferase. (AST) and alkaline phosphatase (ALP) were found to be reduced in rats that were pretreated with zerumbone compared to group that was treated with paracetamol only. Correspondingly, there was no hepatocellular necrosis observed in rats that were pretreated with zerumbone. The results obtained may have suggested that zerumbone exert hepatoprotective activities against paracetamol induced hepatotoxicity. Asian Network for Scientific Information 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14996/1/Hepatoprotective%20action%20of%20zerumbone%20against%20paracetamol%20induced%20hepatotoxicity.pdf Fakurazi, Sharida and Ithnin, Hairuszah and Jabit, Mohd Lip and Ganabadi, Shanti and Nanthini, Uma and Abdul Rahman, Shamima and Abd Hamid @ Abdul Razak, Roslida and Tan, Y. H. (2009) Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity. Journal of Medical Sciences, 9 (3). pp. 161-164. ISSN 1682-4474; ESSN: 1812-5727 http://www.scialert.net/abstract/?doi=jms.2009.161.164 10.3923/jms.2009.161.164
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This study is conducted to investigate the possible effect of zerumbone towards hepatoprotective activity against paracetamol intoxication. Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals. Group I was administered with 0.2% zerumbone for 14 days prior to 3 g kg-1 paracetamol administration. Group II was given paracetamol early and group III was given 200 mg kg-1 of silymarin and paracetamol. Group IV was administered with zerumbone only and finally group V was treated with corn oil and 40% sucrose buffer as vehicle treated group. Animals were sacrificed at 4 and 24 h post treatment following diethyl ether. There was no significant changes in liver enzyme activities as well as histological observations at 4 h after paracetamol administration. Meanwhile, 24 h after paracetamol administration, the level of alanine aminotransferase (ALT), aspartate aminotransferase. (AST) and alkaline phosphatase (ALP) were found to be reduced in rats that were pretreated with zerumbone compared to group that was treated with paracetamol only. Correspondingly, there was no hepatocellular necrosis observed in rats that were pretreated with zerumbone. The results obtained may have suggested that zerumbone exert hepatoprotective activities against paracetamol induced hepatotoxicity.
format Article
author Fakurazi, Sharida
Ithnin, Hairuszah
Jabit, Mohd Lip
Ganabadi, Shanti
Nanthini, Uma
Abdul Rahman, Shamima
Abd Hamid @ Abdul Razak, Roslida
Tan, Y. H.
spellingShingle Fakurazi, Sharida
Ithnin, Hairuszah
Jabit, Mohd Lip
Ganabadi, Shanti
Nanthini, Uma
Abdul Rahman, Shamima
Abd Hamid @ Abdul Razak, Roslida
Tan, Y. H.
Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
author_facet Fakurazi, Sharida
Ithnin, Hairuszah
Jabit, Mohd Lip
Ganabadi, Shanti
Nanthini, Uma
Abdul Rahman, Shamima
Abd Hamid @ Abdul Razak, Roslida
Tan, Y. H.
author_sort Fakurazi, Sharida
title Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
title_short Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
title_full Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
title_fullStr Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
title_full_unstemmed Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
title_sort hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity
publisher Asian Network for Scientific Information
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/14996/1/Hepatoprotective%20action%20of%20zerumbone%20against%20paracetamol%20induced%20hepatotoxicity.pdf
http://psasir.upm.edu.my/id/eprint/14996/
http://www.scialert.net/abstract/?doi=jms.2009.161.164
_version_ 1643825801133555712
score 13.211869

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