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Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study

A case-control study was conducted to establish a database of ESR1 polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagno...

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Main Authors: Abbasi, Sakineh, Ismail, Patimah, Othman, Fauziah, Rosli, Rozita, Azimi, Cyrus
Format: Article
Language:English
Published: Asian Network for Scientific Information 2009
Online Access:http://psasir.upm.edu.my/id/eprint/14576/1/14576.pdf
http://psasir.upm.edu.my/id/eprint/14576/
https://scialert.net/abstract/?doi=ajsr.2009.51.60
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spelling my.upm.eprints.145762019-03-13T04:26:09Z http://psasir.upm.edu.my/id/eprint/14576/ Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study Abbasi, Sakineh Ismail, Patimah Othman, Fauziah Rosli, Rozita Azimi, Cyrus A case-control study was conducted to establish a database of ESR1 polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagnosed invasive breast tumors, (150 patients) and in healthy individuals (147 healthy control individuals). PCR single-strand conformation polymorphism technology and direct sequencing was performed. The silent single nucleotide polymorphism (SNPs) was found, as reported previously in other studies, but at significantly different frequencies. The frequency of genotype 01 in codon 594 (ACG-ACA), (G3242A), exon 8 was significantly higher in breast cancer patients (48.0%) than in control individuals (1.4%; p = 0.001). The allele 1 in codon 594 was significantly more common in breast cancer patients with age at menarche </=12 (40.8%) than in those which their menstruation began at older than 12 years old (23.9%; p = 0.002). The allele 1 in codon 594 exhibited, the greater the frequency, the lesser the likelihood of LN metastasis. Present results demonstrated that this particular SNP marker may increase accuracy in predicting LN. Therefore, this SNP marker further increased predictive accuracy in Iranian population. These data suggest that ESR1 polymorphisms are correlated with various aspects of breast cancer in Iranian ESR1 genotype, as determined during pre-surgical evaluation, might represent a surrogate marker to increase predicting breast cancer in Iranian population. Asian Network for Scientific Information 2009 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/14576/1/14576.pdf Abbasi, Sakineh and Ismail, Patimah and Othman, Fauziah and Rosli, Rozita and Azimi, Cyrus (2009) Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study. Asian Journal of Scientific Research, 2 (1). pp. 51-60. ISSN 1992-1454; ESSN: 2077-2076 https://scialert.net/abstract/?doi=ajsr.2009.51.60 10.3923/ajsr.2009.51.60
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A case-control study was conducted to establish a database of ESR1 polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagnosed invasive breast tumors, (150 patients) and in healthy individuals (147 healthy control individuals). PCR single-strand conformation polymorphism technology and direct sequencing was performed. The silent single nucleotide polymorphism (SNPs) was found, as reported previously in other studies, but at significantly different frequencies. The frequency of genotype 01 in codon 594 (ACG-ACA), (G3242A), exon 8 was significantly higher in breast cancer patients (48.0%) than in control individuals (1.4%; p = 0.001). The allele 1 in codon 594 was significantly more common in breast cancer patients with age at menarche </=12 (40.8%) than in those which their menstruation began at older than 12 years old (23.9%; p = 0.002). The allele 1 in codon 594 exhibited, the greater the frequency, the lesser the likelihood of LN metastasis. Present results demonstrated that this particular SNP marker may increase accuracy in predicting LN. Therefore, this SNP marker further increased predictive accuracy in Iranian population. These data suggest that ESR1 polymorphisms are correlated with various aspects of breast cancer in Iranian ESR1 genotype, as determined during pre-surgical evaluation, might represent a surrogate marker to increase predicting breast cancer in Iranian population.
format Article
author Abbasi, Sakineh
Ismail, Patimah
Othman, Fauziah
Rosli, Rozita
Azimi, Cyrus
spellingShingle Abbasi, Sakineh
Ismail, Patimah
Othman, Fauziah
Rosli, Rozita
Azimi, Cyrus
Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
author_facet Abbasi, Sakineh
Ismail, Patimah
Othman, Fauziah
Rosli, Rozita
Azimi, Cyrus
author_sort Abbasi, Sakineh
title Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
title_short Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
title_full Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
title_fullStr Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
title_full_unstemmed Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
title_sort estrogen receptor-α gene, codon 594 (g3242a) polymorphism among iranian women with breast cancer: a case control study
publisher Asian Network for Scientific Information
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/14576/1/14576.pdf
http://psasir.upm.edu.my/id/eprint/14576/
https://scialert.net/abstract/?doi=ajsr.2009.51.60
_version_ 1643825673718988800
score 13.211869

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