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Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study

A case study was conducted to establish a database of polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagnosed invasive...

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Main Authors: Abbasi, Sakineh, Azimi, Cyrus, Othman, Fauziah, Daloii, Mohammad Reza Noori, Ashtiani, Zahra Ousati, Mojarrad, Majid, Oskouei, S. A., Nejad, F. M., Ismail, Patimah
Format: Article
Language:English
Published: Asian Network for Scientific Information 2009
Online Access:http://psasir.upm.edu.my/id/eprint/14575/1/Estrogen%20receptor-%CE%B1%20gene%20codon%2010%20%28T392C%29%20polymorphism%20in%20Iranian%20women%20with%20breast%20cancer%20a%20case%20study.pdf
http://psasir.upm.edu.my/id/eprint/14575/
https://scialert.net/abstract/?doi=tms.2009.1.10
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spelling my.upm.eprints.145752019-04-08T08:53:12Z http://psasir.upm.edu.my/id/eprint/14575/ Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study Abbasi, Sakineh Azimi, Cyrus Othman, Fauziah Daloii, Mohammad Reza Noori Ashtiani, Zahra Ousati Mojarrad, Majid Oskouei, S. A. Nejad, F. M. Ismail, Patimah A case study was conducted to establish a database of polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagnosed invasive breast tumors, (150 patients) and in healthy individuals (147 healthy control individuals). PCR single-strand conformation polymorphism methodology and direct sequencing were performed. The silent single nucleotide polymorphism (SNPs) was performed, as reported previously in other studies, but at significantly different frequencies, with further increasing predictive accuracy in Iranian population. Data suggest that ESR1 polymorphisms are correlated with various aspects of breast cancer in Iranian ESR1 genotype, as determined during pre-surgical evaluation, might represent a surrogate marker for predicting breast cancer. Asian Network for Scientific Information 2009 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/14575/1/Estrogen%20receptor-%CE%B1%20gene%20codon%2010%20%28T392C%29%20polymorphism%20in%20Iranian%20women%20with%20breast%20cancer%20a%20case%20study.pdf Abbasi, Sakineh and Azimi, Cyrus and Othman, Fauziah and Daloii, Mohammad Reza Noori and Ashtiani, Zahra Ousati and Mojarrad, Majid and Oskouei, S. A. and Nejad, F. M. and Ismail, Patimah (2009) Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study. Trends in Molecular Sciences, 1 (1). pp. 1-10. ISSN 1994-5469; ESSN: 2077-2270 https://scialert.net/abstract/?doi=tms.2009.1.10 10.3923/tms.2009.1.10
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A case study was conducted to establish a database of polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome. The ESR1 gene was scanned in Iranian patients newly diagnosed invasive breast tumors, (150 patients) and in healthy individuals (147 healthy control individuals). PCR single-strand conformation polymorphism methodology and direct sequencing were performed. The silent single nucleotide polymorphism (SNPs) was performed, as reported previously in other studies, but at significantly different frequencies, with further increasing predictive accuracy in Iranian population. Data suggest that ESR1 polymorphisms are correlated with various aspects of breast cancer in Iranian ESR1 genotype, as determined during pre-surgical evaluation, might represent a surrogate marker for predicting breast cancer.
format Article
author Abbasi, Sakineh
Azimi, Cyrus
Othman, Fauziah
Daloii, Mohammad Reza Noori
Ashtiani, Zahra Ousati
Mojarrad, Majid
Oskouei, S. A.
Nejad, F. M.
Ismail, Patimah
spellingShingle Abbasi, Sakineh
Azimi, Cyrus
Othman, Fauziah
Daloii, Mohammad Reza Noori
Ashtiani, Zahra Ousati
Mojarrad, Majid
Oskouei, S. A.
Nejad, F. M.
Ismail, Patimah
Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
author_facet Abbasi, Sakineh
Azimi, Cyrus
Othman, Fauziah
Daloii, Mohammad Reza Noori
Ashtiani, Zahra Ousati
Mojarrad, Majid
Oskouei, S. A.
Nejad, F. M.
Ismail, Patimah
author_sort Abbasi, Sakineh
title Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
title_short Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
title_full Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
title_fullStr Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
title_full_unstemmed Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
title_sort estrogen receptor-α gene codon 10 (t392c) polymorphism in iranian women with breast cancer: a case study
publisher Asian Network for Scientific Information
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/14575/1/Estrogen%20receptor-%CE%B1%20gene%20codon%2010%20%28T392C%29%20polymorphism%20in%20Iranian%20women%20with%20breast%20cancer%20a%20case%20study.pdf
http://psasir.upm.edu.my/id/eprint/14575/
https://scialert.net/abstract/?doi=tms.2009.1.10
_version_ 1643825673423290368
score 13.211869

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