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Elevated neutrophil respiratory burst activity in essential hypertensive patients.

Neutrophils play a significant role in maintaining the integrity of innate immunity via their potent respiratory burst activity. However, the uncontrolled activation of respiratory burst in neutrophils also attributes to chronic diseases such as primary hypertension and atherosclerosis. In our study...

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Main Authors: Ramasamy, Rajesh, Maqbool, Maryam, Mohamed, Abdul Latiff, Noah, Rahim Md
Format: Article
Language:English
English
Published: Elsevier 2010
Online Access:http://psasir.upm.edu.my/id/eprint/14478/2/Elevated%20neutrophil%20respiratory%20burst%20activity%20in%20essential%20hypertensive%20patients.pdf
http://psasir.upm.edu.my/id/eprint/14478/
http://www.journals.elsevier.com/cellular-immunology/
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spelling my.upm.eprints.144782015-11-02T04:07:24Z http://psasir.upm.edu.my/id/eprint/14478/ Elevated neutrophil respiratory burst activity in essential hypertensive patients. Ramasamy, Rajesh Maqbool, Maryam Mohamed, Abdul Latiff Noah, Rahim Md Neutrophils play a significant role in maintaining the integrity of innate immunity via their potent respiratory burst activity. However, the uncontrolled activation of respiratory burst in neutrophils also attributes to chronic diseases such as primary hypertension and atherosclerosis. In our study, we have investigated the activation of respiratory burst function of neutrophils harvested from essential hypertensive patients. In the presence of stimuli PMA and opsonized zymosan (OZ), hypertensive patients' neutrophils secrete significantly higher amount of superoxide anions compared to normotensive control. Although the magnitude of activation varies between both groups, yet the kinetics of activation is similar. When normotensive control's neutrophils were pre-treated with hypertensive serum, the cells failed to migrate toward fMLP which indicates the impairment of the migration property. In conclusion, the respiratory burst activity of neutrophils is affected by hypertension and their elevated superoxide anions production could be an aggravating factor in hypertension-related complication Elsevier 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14478/2/Elevated%20neutrophil%20respiratory%20burst%20activity%20in%20essential%20hypertensive%20patients.pdf Ramasamy, Rajesh and Maqbool, Maryam and Mohamed, Abdul Latiff and Noah, Rahim Md (2010) Elevated neutrophil respiratory burst activity in essential hypertensive patients. Cellular Immunology, 263 (2). pp. 230-234. ISSN 0008-8749; ESSN: 1090-2163 http://www.journals.elsevier.com/cellular-immunology/ 10.1016/j.cellimm.2010.04.004 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Neutrophils play a significant role in maintaining the integrity of innate immunity via their potent respiratory burst activity. However, the uncontrolled activation of respiratory burst in neutrophils also attributes to chronic diseases such as primary hypertension and atherosclerosis. In our study, we have investigated the activation of respiratory burst function of neutrophils harvested from essential hypertensive patients. In the presence of stimuli PMA and opsonized zymosan (OZ), hypertensive patients' neutrophils secrete significantly higher amount of superoxide anions compared to normotensive control. Although the magnitude of activation varies between both groups, yet the kinetics of activation is similar. When normotensive control's neutrophils were pre-treated with hypertensive serum, the cells failed to migrate toward fMLP which indicates the impairment of the migration property. In conclusion, the respiratory burst activity of neutrophils is affected by hypertension and their elevated superoxide anions production could be an aggravating factor in hypertension-related complication
format Article
author Ramasamy, Rajesh
Maqbool, Maryam
Mohamed, Abdul Latiff
Noah, Rahim Md
spellingShingle Ramasamy, Rajesh
Maqbool, Maryam
Mohamed, Abdul Latiff
Noah, Rahim Md
Elevated neutrophil respiratory burst activity in essential hypertensive patients.
author_facet Ramasamy, Rajesh
Maqbool, Maryam
Mohamed, Abdul Latiff
Noah, Rahim Md
author_sort Ramasamy, Rajesh
title Elevated neutrophil respiratory burst activity in essential hypertensive patients.
title_short Elevated neutrophil respiratory burst activity in essential hypertensive patients.
title_full Elevated neutrophil respiratory burst activity in essential hypertensive patients.
title_fullStr Elevated neutrophil respiratory burst activity in essential hypertensive patients.
title_full_unstemmed Elevated neutrophil respiratory burst activity in essential hypertensive patients.
title_sort elevated neutrophil respiratory burst activity in essential hypertensive patients.
publisher Elsevier
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/14478/2/Elevated%20neutrophil%20respiratory%20burst%20activity%20in%20essential%20hypertensive%20patients.pdf
http://psasir.upm.edu.my/id/eprint/14478/
http://www.journals.elsevier.com/cellular-immunology/
_version_ 1643825644714328064
score 13.211869

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