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Effects of Morinda citrifolia on early stage of leukaemia in rats

We have studied the effects of Morinda citrifolia on haemogram parameters in rats with early stage of leukaemia. A total of 32 male Sprague Dawley rats were divided into four groups (n=8) namely control, Morinda citrifolia (MC), N-methyl-N-nitrosourea (MNU) and MC+MNU group. Leukaemia induced rats w...

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Main Authors: Hamzah, Hazilawati, Haron, Nursyuhada, Shaari, Mohd Rosly, Sithambaram, Shanmugavelu, Mohamed Mustapha, Noordin
Format: Article
Language:English
Published: Malaysian Medical Association 2010
Online Access:http://psasir.upm.edu.my/id/eprint/14392/1/Effects%20of%20Morinda%20citrifolia%20on%20early%20stage%20of%20leukaemia%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/14392/
http://www.e-mjm.org/2010/Sup_tissue_engineering_content.pdf
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spelling my.upm.eprints.143922016-11-21T08:32:35Z http://psasir.upm.edu.my/id/eprint/14392/ Effects of Morinda citrifolia on early stage of leukaemia in rats Hamzah, Hazilawati Haron, Nursyuhada Shaari, Mohd Rosly Sithambaram, Shanmugavelu Mohamed Mustapha, Noordin We have studied the effects of Morinda citrifolia on haemogram parameters in rats with early stage of leukaemia. A total of 32 male Sprague Dawley rats were divided into four groups (n=8) namely control, Morinda citrifolia (MC), N-methyl-N-nitrosourea (MNU) and MC+MNU group. Leukaemia induced rats were provided with died M. citrifolia fruits incorporated into rat diet at a dose of 3000 mg/kg body weight were given daily to the MC and MC+MNU groups. Results showed there were no significant differences in the leukon and erythron parameters in all groups. Although lymphocytosis was not observed in the MNU and MC+MNU groups, examination of the blood morphology showed a typical morphology of leukaemic cell. Seventy-five and sixty percent of rats in the MNU and MC+MNU groups, respectively, had leukaemia. Our results indicate that examination of blood smear provides an important tool for diagnosis of early stage of leukaemia and daily supplementation of M. citrifolia at the dose of 3000 mg/kg reduced the incidence of early stage of leukaemia in rats. Malaysian Medical Association 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14392/1/Effects%20of%20Morinda%20citrifolia%20on%20early%20stage%20of%20leukaemia%20in%20rats.pdf Hamzah, Hazilawati and Haron, Nursyuhada and Shaari, Mohd Rosly and Sithambaram, Shanmugavelu and Mohamed Mustapha, Noordin (2010) Effects of Morinda citrifolia on early stage of leukaemia in rats. Medical Journal of Malaysia, 65 (suppl.B). pp. 135-136. ISSN 0300-5283 http://www.e-mjm.org/2010/Sup_tissue_engineering_content.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description We have studied the effects of Morinda citrifolia on haemogram parameters in rats with early stage of leukaemia. A total of 32 male Sprague Dawley rats were divided into four groups (n=8) namely control, Morinda citrifolia (MC), N-methyl-N-nitrosourea (MNU) and MC+MNU group. Leukaemia induced rats were provided with died M. citrifolia fruits incorporated into rat diet at a dose of 3000 mg/kg body weight were given daily to the MC and MC+MNU groups. Results showed there were no significant differences in the leukon and erythron parameters in all groups. Although lymphocytosis was not observed in the MNU and MC+MNU groups, examination of the blood morphology showed a typical morphology of leukaemic cell. Seventy-five and sixty percent of rats in the MNU and MC+MNU groups, respectively, had leukaemia. Our results indicate that examination of blood smear provides an important tool for diagnosis of early stage of leukaemia and daily supplementation of M. citrifolia at the dose of 3000 mg/kg reduced the incidence of early stage of leukaemia in rats.
format Article
author Hamzah, Hazilawati
Haron, Nursyuhada
Shaari, Mohd Rosly
Sithambaram, Shanmugavelu
Mohamed Mustapha, Noordin
spellingShingle Hamzah, Hazilawati
Haron, Nursyuhada
Shaari, Mohd Rosly
Sithambaram, Shanmugavelu
Mohamed Mustapha, Noordin
Effects of Morinda citrifolia on early stage of leukaemia in rats
author_facet Hamzah, Hazilawati
Haron, Nursyuhada
Shaari, Mohd Rosly
Sithambaram, Shanmugavelu
Mohamed Mustapha, Noordin
author_sort Hamzah, Hazilawati
title Effects of Morinda citrifolia on early stage of leukaemia in rats
title_short Effects of Morinda citrifolia on early stage of leukaemia in rats
title_full Effects of Morinda citrifolia on early stage of leukaemia in rats
title_fullStr Effects of Morinda citrifolia on early stage of leukaemia in rats
title_full_unstemmed Effects of Morinda citrifolia on early stage of leukaemia in rats
title_sort effects of morinda citrifolia on early stage of leukaemia in rats
publisher Malaysian Medical Association
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/14392/1/Effects%20of%20Morinda%20citrifolia%20on%20early%20stage%20of%20leukaemia%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/14392/
http://www.e-mjm.org/2010/Sup_tissue_engineering_content.pdf
_version_ 1643825617962008576
score 13.211869

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