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Caenorhabditis elegans-based analysis of Salmonella enterica

Caenorhabditis elegans (C. elegans) have been widely used as an infection model for mammalian related pathogens with promising results. The bacterial factors required for virulence in non-mammalian host C. elegans play a role in mammalian systems. Previous reported that Salmonella found in vegetable...

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Main Authors: Khoo, Chai Hoon, Sim, Jiun Horng, Mohd Sidik, Shiran, Radu, Son, Sukardi, Sabrina, Awang Salleh, Noorzaleha, Lee, Learn Han, Cheah, Yoke Kqueen
Format: Article
Language:English
Published: Faculty of Food Science and Technology, Universiti Putra Malaysia 2010
Online Access:http://psasir.upm.edu.my/id/eprint/13471/1/13471.pdf
http://psasir.upm.edu.my/id/eprint/13471/
http://www.ifrj.upm.edu.my/17%20%2804%29%202010/%283%29%20IFRJ-2010-064%20Kqueen%5B1%5D.pdf
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spelling my.upm.eprints.134712015-09-25T03:00:37Z http://psasir.upm.edu.my/id/eprint/13471/ Caenorhabditis elegans-based analysis of Salmonella enterica Khoo, Chai Hoon Sim, Jiun Horng Mohd Sidik, Shiran Radu, Son Sukardi, Sabrina Awang Salleh, Noorzaleha Lee, Learn Han Cheah, Yoke Kqueen Caenorhabditis elegans (C. elegans) have been widely used as an infection model for mammalian related pathogens with promising results. The bacterial factors required for virulence in non-mammalian host C. elegans play a role in mammalian systems. Previous reported that Salmonella found in vegetable and poultry meat could be potential health hazards to human. This study evaluated the pathogenicity of various serovars of Salmonella enterica (S. enterica) that recovered from local indigenous vegetables and poultry meat using C. elegans as a simple host model. Almost all S. enterica isolates were capable of colonizing the intestine of C. elegans, causing a significant reduction in the survival of nematodes. The colonization of Salmonella in C. elegans revealed that the ability of S. enterica in killing C. elegans correlates with its accumulation in the intestine to achieve full pathogenicity. Using this model, the virulence mechanisms of opportunistic pathogenic S. enterica were found to be not only relevant for the interactions of the bacteria with C. elegans but also with mammalian hosts including humans. Hence, C. elegans model could provide valuable insight into preliminary factors from the host that contributes to the environmental bacterial pathogenesis scenario. Faculty of Food Science and Technology, Universiti Putra Malaysia 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13471/1/13471.pdf Khoo, Chai Hoon and Sim, Jiun Horng and Mohd Sidik, Shiran and Radu, Son and Sukardi, Sabrina and Awang Salleh, Noorzaleha and Lee, Learn Han and Cheah, Yoke Kqueen (2010) Caenorhabditis elegans-based analysis of Salmonella enterica. International Food Research Journal, 17 (4). pp. 845-852. ISSN 1985-4668; ESSN: 2231-7546 http://www.ifrj.upm.edu.my/17%20%2804%29%202010/%283%29%20IFRJ-2010-064%20Kqueen%5B1%5D.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Caenorhabditis elegans (C. elegans) have been widely used as an infection model for mammalian related pathogens with promising results. The bacterial factors required for virulence in non-mammalian host C. elegans play a role in mammalian systems. Previous reported that Salmonella found in vegetable and poultry meat could be potential health hazards to human. This study evaluated the pathogenicity of various serovars of Salmonella enterica (S. enterica) that recovered from local indigenous vegetables and poultry meat using C. elegans as a simple host model. Almost all S. enterica isolates were capable of colonizing the intestine of C. elegans, causing a significant reduction in the survival of nematodes. The colonization of Salmonella in C. elegans revealed that the ability of S. enterica in killing C. elegans correlates with its accumulation in the intestine to achieve full pathogenicity. Using this model, the virulence mechanisms of opportunistic pathogenic S. enterica were found to be not only relevant for the interactions of the bacteria with C. elegans but also with mammalian hosts including humans. Hence, C. elegans model could provide valuable insight into preliminary factors from the host that contributes to the environmental bacterial pathogenesis scenario.
format Article
author Khoo, Chai Hoon
Sim, Jiun Horng
Mohd Sidik, Shiran
Radu, Son
Sukardi, Sabrina
Awang Salleh, Noorzaleha
Lee, Learn Han
Cheah, Yoke Kqueen
spellingShingle Khoo, Chai Hoon
Sim, Jiun Horng
Mohd Sidik, Shiran
Radu, Son
Sukardi, Sabrina
Awang Salleh, Noorzaleha
Lee, Learn Han
Cheah, Yoke Kqueen
Caenorhabditis elegans-based analysis of Salmonella enterica
author_facet Khoo, Chai Hoon
Sim, Jiun Horng
Mohd Sidik, Shiran
Radu, Son
Sukardi, Sabrina
Awang Salleh, Noorzaleha
Lee, Learn Han
Cheah, Yoke Kqueen
author_sort Khoo, Chai Hoon
title Caenorhabditis elegans-based analysis of Salmonella enterica
title_short Caenorhabditis elegans-based analysis of Salmonella enterica
title_full Caenorhabditis elegans-based analysis of Salmonella enterica
title_fullStr Caenorhabditis elegans-based analysis of Salmonella enterica
title_full_unstemmed Caenorhabditis elegans-based analysis of Salmonella enterica
title_sort caenorhabditis elegans-based analysis of salmonella enterica
publisher Faculty of Food Science and Technology, Universiti Putra Malaysia
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/13471/1/13471.pdf
http://psasir.upm.edu.my/id/eprint/13471/
http://www.ifrj.upm.edu.my/17%20%2804%29%202010/%283%29%20IFRJ-2010-064%20Kqueen%5B1%5D.pdf
_version_ 1643825341295230976
score 13.211869

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