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Biological activities of four Melicope species

The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the th...

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Main Authors: Mohd Hashim, Najihah, Rahmani, Mawardi, Mohd Ismail, Hazar Bebe, Md. Sukari, Mohd. Aspollah, Ali, Abdul Manaf, Ee, Gwendoline Cheng Lian
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2009
Online Access:http://psasir.upm.edu.my/id/eprint/13415/1/Biological%20activities%20of%20four%20Melicope%20species.pdf
http://psasir.upm.edu.my/id/eprint/13415/
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spelling my.upm.eprints.134152015-10-22T04:25:17Z http://psasir.upm.edu.my/id/eprint/13415/ Biological activities of four Melicope species Mohd Hashim, Najihah Rahmani, Mawardi Mohd Ismail, Hazar Bebe Md. Sukari, Mohd. Aspollah Ali, Abdul Manaf Ee, Gwendoline Cheng Lian The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the three pathogenic fungi. However, when tested against pathogenic bacteria, the three leaves extracts showed strong activity against methicillin resistant S. aureus and moderate for the other bacteria. In the antioxidant assay by using DPPH, the three leaves extracts of M. lunu-ankenda exhibited significant activity with with IC50 values of 7.8, 15.6 and 7.8 μg/mL. In addition, the petroleum ether leaves extract of M. clemensiae and the chloroform leaves extract of M. lunu-ankenda showed strong cytotoxic activity when tested against human promyelocytic leukemia (HL60) cell line with IC50 values of 2.8 and 0.8 μg/mL, respectively. Universiti Kebangsaan Malaysia 2009 Article NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13415/1/Biological%20activities%20of%20four%20Melicope%20species.pdf Mohd Hashim, Najihah and Rahmani, Mawardi and Mohd Ismail, Hazar Bebe and Md. Sukari, Mohd. Aspollah and Ali, Abdul Manaf and Ee, Gwendoline Cheng Lian (2009) Biological activities of four Melicope species. Sains Malaysiana, 38 (5). pp. 767-771. ISSN 0026-6039
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the three pathogenic fungi. However, when tested against pathogenic bacteria, the three leaves extracts showed strong activity against methicillin resistant S. aureus and moderate for the other bacteria. In the antioxidant assay by using DPPH, the three leaves extracts of M. lunu-ankenda exhibited significant activity with with IC50 values of 7.8, 15.6 and 7.8 μg/mL. In addition, the petroleum ether leaves extract of M. clemensiae and the chloroform leaves extract of M. lunu-ankenda showed strong cytotoxic activity when tested against human promyelocytic leukemia (HL60) cell line with IC50 values of 2.8 and 0.8 μg/mL, respectively.
format Article
author Mohd Hashim, Najihah
Rahmani, Mawardi
Mohd Ismail, Hazar Bebe
Md. Sukari, Mohd. Aspollah
Ali, Abdul Manaf
Ee, Gwendoline Cheng Lian
spellingShingle Mohd Hashim, Najihah
Rahmani, Mawardi
Mohd Ismail, Hazar Bebe
Md. Sukari, Mohd. Aspollah
Ali, Abdul Manaf
Ee, Gwendoline Cheng Lian
Biological activities of four Melicope species
author_facet Mohd Hashim, Najihah
Rahmani, Mawardi
Mohd Ismail, Hazar Bebe
Md. Sukari, Mohd. Aspollah
Ali, Abdul Manaf
Ee, Gwendoline Cheng Lian
author_sort Mohd Hashim, Najihah
title Biological activities of four Melicope species
title_short Biological activities of four Melicope species
title_full Biological activities of four Melicope species
title_fullStr Biological activities of four Melicope species
title_full_unstemmed Biological activities of four Melicope species
title_sort biological activities of four melicope species
publisher Universiti Kebangsaan Malaysia
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/13415/1/Biological%20activities%20of%20four%20Melicope%20species.pdf
http://psasir.upm.edu.my/id/eprint/13415/
_version_ 1643825324987777024
score 13.211869

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