Cover Image

Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats

An in vivo study was conducted to determine the effect of tamoxifen-loaded solid lipid nanoparticle on LA7 cell-induced rat mammary tumor. After the first tumors appearance, the thirty rats were divided into five groups. Group I served as normal control animal. The other four groups were mammary gla...

Full description

Saved in:
Bibliographic Details
Main Authors: Abbasalipourkabirreh, Roghayeh, Salehzadeh, Aref, Abdullah, Rasedee
Format: Article
Language:English
Published: Academic Journals 2010
Online Access:http://psasir.upm.edu.my/id/eprint/13209/1/13209.pdf
http://psasir.upm.edu.my/id/eprint/13209/
http://www.academicjournals.org/journal/AJB/article-abstract/31BD94F26064
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.13209
record_format eprints
spelling my.upm.eprints.132092016-06-30T02:22:43Z http://psasir.upm.edu.my/id/eprint/13209/ Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats Abbasalipourkabirreh, Roghayeh Salehzadeh, Aref Abdullah, Rasedee An in vivo study was conducted to determine the effect of tamoxifen-loaded solid lipid nanoparticle on LA7 cell-induced rat mammary tumor. After the first tumors appearance, the thirty rats were divided into five groups. Group I served as normal control animal. The other four groups were mammary gland tumor-bearing animals treated with soy oil (Group II), tamoxifen (TAM) dissolved in soy oil (Group III), tamoxifen-loaded solid lipid nanoparticle (Group IV) and solid lipid nanoparticle (SLN) (Group V) dispersed in soy oil. The effect of TAM-loaded SLN in the reduction of tumor size was greater than that of free TAM. The transmission electron microscope analysis showed apoptosis in TAM-loaded SLN and free TAM treatment groups. After treatment, the rats treated with TAM-loaded SLN showed decreases in concentration of serum enzymes. In conclusion, the study suggests that TAM-loaded SLN is very effective for treatment of rat mammary gland tumors and breast cancers. Academic Journals 2010-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13209/1/13209.pdf Abbasalipourkabirreh, Roghayeh and Salehzadeh, Aref and Abdullah, Rasedee (2010) Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats. African Journal of Biotechnology, 9 (43). art. no. 31BD94F26064. pp. 7337-7345. ISSN 1684–5315 http://www.academicjournals.org/journal/AJB/article-abstract/31BD94F26064
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description An in vivo study was conducted to determine the effect of tamoxifen-loaded solid lipid nanoparticle on LA7 cell-induced rat mammary tumor. After the first tumors appearance, the thirty rats were divided into five groups. Group I served as normal control animal. The other four groups were mammary gland tumor-bearing animals treated with soy oil (Group II), tamoxifen (TAM) dissolved in soy oil (Group III), tamoxifen-loaded solid lipid nanoparticle (Group IV) and solid lipid nanoparticle (SLN) (Group V) dispersed in soy oil. The effect of TAM-loaded SLN in the reduction of tumor size was greater than that of free TAM. The transmission electron microscope analysis showed apoptosis in TAM-loaded SLN and free TAM treatment groups. After treatment, the rats treated with TAM-loaded SLN showed decreases in concentration of serum enzymes. In conclusion, the study suggests that TAM-loaded SLN is very effective for treatment of rat mammary gland tumors and breast cancers.
format Article
author Abbasalipourkabirreh, Roghayeh
Salehzadeh, Aref
Abdullah, Rasedee
spellingShingle Abbasalipourkabirreh, Roghayeh
Salehzadeh, Aref
Abdullah, Rasedee
Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats
author_facet Abbasalipourkabirreh, Roghayeh
Salehzadeh, Aref
Abdullah, Rasedee
author_sort Abbasalipourkabirreh, Roghayeh
title Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats
title_short Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats
title_full Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats
title_fullStr Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats
title_full_unstemmed Antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in Sprague-Dawley rats
title_sort antitumor activity of tamoxifen loaded solid lipid nanoparticles on induced mammary tumor gland in sprague-dawley rats
publisher Academic Journals
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/13209/1/13209.pdf
http://psasir.upm.edu.my/id/eprint/13209/
http://www.academicjournals.org/journal/AJB/article-abstract/31BD94F26064
_version_ 1643825262045954048
score 13.211869

Similar Items