Cover Image

Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.

The current study evaluated the antioxidant and hepatoprotective activities of Elephantopus tomentosus L. (Asteraceae) ethanol extract (ET). In the experiment, total antioxidant capacity, reducing capacity, DPPH* and hydrogen peroxide scavenging, and Fe3 +-induced lipid peroxidation inhibiting activ...

Full description

Saved in:
Bibliographic Details
Main Authors: Yam, Mun Fei, Basir, Rusliza, Asmawil, Mohd Zaini, Rosidah,, Ahmad, Mariam, Akowuah, Gabriel Akyirem
Format: Article
Language:English
Published: Informa Healthcare 2008
Online Access:http://psasir.upm.edu.my/id/eprint/13185/1/Antioxidant%20and%20hepatoprotective%20activities%20of%20Elephantopus%20tomentosus%20ethanol%20extract.pdf
http://psasir.upm.edu.my/id/eprint/13185/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.13185
record_format eprints
spelling my.upm.eprints.131852015-11-11T00:51:38Z http://psasir.upm.edu.my/id/eprint/13185/ Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. Yam, Mun Fei Basir, Rusliza Asmawil, Mohd Zaini Rosidah, Ahmad, Mariam Akowuah, Gabriel Akyirem The current study evaluated the antioxidant and hepatoprotective activities of Elephantopus tomentosus L. (Asteraceae) ethanol extract (ET). In the experiment, total antioxidant capacity, reducing capacity, DPPH* and hydrogen peroxide scavenging, and Fe3 +-induced lipid peroxidation inhibiting activities of ET were determined. The results indicated that ET exhibited antioxidant (1 mg/mL ET was equal to 2.1 mM TEAC), lipid peroxidation inhibition, hydrogen peroxide, and free radical scavenging activities. The hepatoprotective activity of ET was studied using CCl4-induced liver toxicity in rats. Oral administration of ET (500 mg/kg) significantly reduced CCl4-induced hepatotoxicity in rats, as observed from the serum level of the liver enzyme aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also from the histopathologic study. The total phenolic content in the lyophilized ethanol extract is approximately 10%. The results of the current study indicated that the hepatoprotective effect of E. tomentosus might be ascribable to its antioxidant and free radical scavenging properties. Informa Healthcare 2008-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13185/1/Antioxidant%20and%20hepatoprotective%20activities%20of%20Elephantopus%20tomentosus%20ethanol%20extract.pdf Yam, Mun Fei and Basir, Rusliza and Asmawil, Mohd Zaini and Rosidah, and Ahmad, Mariam and Akowuah, Gabriel Akyirem (2008) Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. Pharmaceutical Biology, 46 (3). pp. 199-206. ISSN 1388-0209; ESSN: 1744-5116 10.1080/13880200701735569
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The current study evaluated the antioxidant and hepatoprotective activities of Elephantopus tomentosus L. (Asteraceae) ethanol extract (ET). In the experiment, total antioxidant capacity, reducing capacity, DPPH* and hydrogen peroxide scavenging, and Fe3 +-induced lipid peroxidation inhibiting activities of ET were determined. The results indicated that ET exhibited antioxidant (1 mg/mL ET was equal to 2.1 mM TEAC), lipid peroxidation inhibition, hydrogen peroxide, and free radical scavenging activities. The hepatoprotective activity of ET was studied using CCl4-induced liver toxicity in rats. Oral administration of ET (500 mg/kg) significantly reduced CCl4-induced hepatotoxicity in rats, as observed from the serum level of the liver enzyme aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also from the histopathologic study. The total phenolic content in the lyophilized ethanol extract is approximately 10%. The results of the current study indicated that the hepatoprotective effect of E. tomentosus might be ascribable to its antioxidant and free radical scavenging properties.
format Article
author Yam, Mun Fei
Basir, Rusliza
Asmawil, Mohd Zaini
Rosidah,
Ahmad, Mariam
Akowuah, Gabriel Akyirem
spellingShingle Yam, Mun Fei
Basir, Rusliza
Asmawil, Mohd Zaini
Rosidah,
Ahmad, Mariam
Akowuah, Gabriel Akyirem
Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
author_facet Yam, Mun Fei
Basir, Rusliza
Asmawil, Mohd Zaini
Rosidah,
Ahmad, Mariam
Akowuah, Gabriel Akyirem
author_sort Yam, Mun Fei
title Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
title_short Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
title_full Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
title_fullStr Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
title_full_unstemmed Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract.
title_sort antioxidant and hepatoprotective activities of elephantopus tomentosus ethanol extract.
publisher Informa Healthcare
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/13185/1/Antioxidant%20and%20hepatoprotective%20activities%20of%20Elephantopus%20tomentosus%20ethanol%20extract.pdf
http://psasir.upm.edu.my/id/eprint/13185/
_version_ 1643825254960726016
score 13.211869

Similar Items