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A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability

Cytotoxic precipitation of free α-globin monomers and its production of reactive oxygen species cause red cell membrane damage that leads to anemia and eventually ineffective erythropoiesis in β-thalassemia. Alpha hemoglobin stabilizing protein (AHSP) was found to bind only to free α-globin monomers...

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Main Authors: Lai, Mei I., Garner, Chad, Jiang, Jie, Silver, Nicholas, Best, Steve, Menzel, Stephan, Thein, Swee Lay
Format: Article
Language:English
Published: Cambridge University Press 2010
Online Access:http://psasir.upm.edu.my/id/eprint/12892/1/A%20twins%20heritability%20study%20on%20alpha%20hemoglobin%20stabilizing%20protein.pdf
http://psasir.upm.edu.my/id/eprint/12892/
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spelling my.upm.eprints.128922015-10-05T03:08:08Z http://psasir.upm.edu.my/id/eprint/12892/ A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability Lai, Mei I. Garner, Chad Jiang, Jie Silver, Nicholas Best, Steve Menzel, Stephan Thein, Swee Lay Cytotoxic precipitation of free α-globin monomers and its production of reactive oxygen species cause red cell membrane damage that leads to anemia and eventually ineffective erythropoiesis in β-thalassemia. Alpha hemoglobin stabilizing protein (AHSP) was found to bind only to free α-globin monomers creating a stable and inert complex which remains soluble in the cytoplasm thus preventing harmful precipitations. Alpha hemoglobin stabilizing protein was shown to bind nascent α-globin monomers with transient strength before transferring α-globin to β-globin to form hemoglobin tetramer. A classical twin study would be beneficial to investigate the role of genetics and environment in the variation of alpha hemoglobin stabilizing protein expression as this knowledge will enable us to determine further investigations with regards to therapeutic interventions if alpha hemoglobin stabilizing protein is to be a therapeutic agent for β-thalassemia. This study investigates the heritability influence of alpha hemoglobin stabilizing protein expression and factors that may contribute to this. Results indicated that a major proportion of alpha hemoglobin stabilizing protein expression was influenced by genetic heritability (46%) with cis-acting factors accounting for 19% and trans-acting factors at 27%. Cambridge University Press 2010-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/12892/1/A%20twins%20heritability%20study%20on%20alpha%20hemoglobin%20stabilizing%20protein.pdf Lai, Mei I. and Garner, Chad and Jiang, Jie and Silver, Nicholas and Best, Steve and Menzel, Stephan and Thein, Swee Lay (2010) A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability. Twin Research and Human Genetics, 13 (6). pp. 567-572. ISSN 1832-4274; ESSN: 1839-2628 10.1375/twin.13.6.567
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Cytotoxic precipitation of free α-globin monomers and its production of reactive oxygen species cause red cell membrane damage that leads to anemia and eventually ineffective erythropoiesis in β-thalassemia. Alpha hemoglobin stabilizing protein (AHSP) was found to bind only to free α-globin monomers creating a stable and inert complex which remains soluble in the cytoplasm thus preventing harmful precipitations. Alpha hemoglobin stabilizing protein was shown to bind nascent α-globin monomers with transient strength before transferring α-globin to β-globin to form hemoglobin tetramer. A classical twin study would be beneficial to investigate the role of genetics and environment in the variation of alpha hemoglobin stabilizing protein expression as this knowledge will enable us to determine further investigations with regards to therapeutic interventions if alpha hemoglobin stabilizing protein is to be a therapeutic agent for β-thalassemia. This study investigates the heritability influence of alpha hemoglobin stabilizing protein expression and factors that may contribute to this. Results indicated that a major proportion of alpha hemoglobin stabilizing protein expression was influenced by genetic heritability (46%) with cis-acting factors accounting for 19% and trans-acting factors at 27%.
format Article
author Lai, Mei I.
Garner, Chad
Jiang, Jie
Silver, Nicholas
Best, Steve
Menzel, Stephan
Thein, Swee Lay
spellingShingle Lai, Mei I.
Garner, Chad
Jiang, Jie
Silver, Nicholas
Best, Steve
Menzel, Stephan
Thein, Swee Lay
A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability
author_facet Lai, Mei I.
Garner, Chad
Jiang, Jie
Silver, Nicholas
Best, Steve
Menzel, Stephan
Thein, Swee Lay
author_sort Lai, Mei I.
title A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability
title_short A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability
title_full A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability
title_fullStr A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability
title_full_unstemmed A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability
title_sort twins heritability study on alpha hemoglobin stabilizing protein (ahsp) expression variability
publisher Cambridge University Press
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/12892/1/A%20twins%20heritability%20study%20on%20alpha%20hemoglobin%20stabilizing%20protein.pdf
http://psasir.upm.edu.my/id/eprint/12892/
_version_ 1643825165956546560
score 13.211869

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