Cover Image

Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats

Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of...

Full description

Saved in:
Bibliographic Details
Main Author: Abdullah, Abdul Salam
Format: Thesis
Language:English
English
Published: 1983
Subjects:
Veterinary drugs residues
Online Access:http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf
http://psasir.upm.edu.my/id/eprint/11739/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.11739
record_format eprints
spelling my.upm.eprints.117392024-06-25T08:51:27Z http://psasir.upm.edu.my/id/eprint/11739/ Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats Abdullah, Abdul Salam Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of imidocarb in ruminant and monogastrics pecies , and the influence of fever of different etiology on the disposition kinetics of this drug. The concentration of imidocarb in body fluids and tissues were measured by spectrophotometry.The disposition kinetics of imidocarb in normal and febrile dogs and goats can be adequately described by a two-compartment open model. The apparent volume of the central compartment , V,c was significantly lower (P<0.01) but the volume of distribution, V d(area) was significantly higher (P<0.05) in normal goats than in dogs.Higher volume of distribution and the ratio of imidocarb level in peripheral- to-central compartment in goats ( 6:1 ) prolonged elimination of the drug, resulting in considerably higher levels of the drug still present in the tissues 14 days after a single subcutaneous or intramuscular dose. 1983-09 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf Abdullah, Abdul Salam (1983) Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats. Doctoral thesis, Universiti Pertanian Malaysia. Veterinary drugs residues English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
topic Veterinary drugs residues
spellingShingle Veterinary drugs residues
Abdullah, Abdul Salam
Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
description Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of imidocarb in ruminant and monogastrics pecies , and the influence of fever of different etiology on the disposition kinetics of this drug. The concentration of imidocarb in body fluids and tissues were measured by spectrophotometry.The disposition kinetics of imidocarb in normal and febrile dogs and goats can be adequately described by a two-compartment open model. The apparent volume of the central compartment , V,c was significantly lower (P<0.01) but the volume of distribution, V d(area) was significantly higher (P<0.05) in normal goats than in dogs.Higher volume of distribution and the ratio of imidocarb level in peripheral- to-central compartment in goats ( 6:1 ) prolonged elimination of the drug, resulting in considerably higher levels of the drug still present in the tissues 14 days after a single subcutaneous or intramuscular dose.
format Thesis
author Abdullah, Abdul Salam
author_facet Abdullah, Abdul Salam
author_sort Abdullah, Abdul Salam
title Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_short Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_full Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_fullStr Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_full_unstemmed Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_sort pharmacokinetics of imidocarb in normal and febrile dogs and goats
publishDate 1983
url http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf
http://psasir.upm.edu.my/id/eprint/11739/
_version_ 1802978811456782336
score 13.211869

Similar Items