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Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation

The prevalence of diabetes mellitus is increasing, and well-known conventional medications are associated with harmful effects. Therefore, this study aimed to identify the compounds present in the young leaves of Daniellia oliveri and assess their antidiabetic potential using an in-silico model. The...

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Main Authors: Adeyemi, Sherif Babatunde, Saliu, Ahmed Abiodun, Joshi, Bhrugesh Pravinchandra, Krishnamurthy, Ramar
Format: Article
Language:English
Published: Taylor and Francis 2024
Online Access:http://psasir.upm.edu.my/id/eprint/114865/1/114865.pdf
http://psasir.upm.edu.my/id/eprint/114865/
https://www.tandfonline.com/doi/full/10.1080/2314808X.2024.2434995
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spelling my.upm.eprints.1148652025-02-05T03:49:25Z http://psasir.upm.edu.my/id/eprint/114865/ Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation Adeyemi, Sherif Babatunde Saliu, Ahmed Abiodun Joshi, Bhrugesh Pravinchandra Krishnamurthy, Ramar The prevalence of diabetes mellitus is increasing, and well-known conventional medications are associated with harmful effects. Therefore, this study aimed to identify the compounds present in the young leaves of Daniellia oliveri and assess their antidiabetic potential using an in-silico model. The best column chromatographic fraction obtained from ethyl acetate fraction was analyzed using HRLC-MS to identify the prominent compounds. The identified compounds were subjected to ADMET prediction using online servers to confirm their draggability. In addition, the compounds were screened for activity against type 2 diabetes using molecular docking. Eight compounds with prominent peaks were identified, viz; gallic acid, 2,6-dihydroxybenzoic acid, salicylic acid, caffeic acid, phenylacetaldehyde, 2,5-dimethylphenol, 3-(−4-Hydroxyphenyl) propionic acid, and 16-hydroxyhexadecanoic acid. Most of the identified compounds were phenolics and had little toxic effects. The molecular docking results revealed the potentials of the identified compounds in inhibiting the therapeutic targets viz; 11β-hydroxysteroid dehydrogenase type 1, human salivary alpha-amylase, glycogen phosphorylase, human protein tyrosine phosphatase 1B, glutamine fructose-6-phosphate amidotransferase, human sirtuin 6, and dipeptidyl peptidase IV, responsible for the development of type 2 diabetes. This study has successfully revalidated and provided scientific insight into the usage of D. oliveri in managing type 2 diabetes by Nigerians. However, the limitation of this study remains the purification of the lead compounds that can serve as lead for type 2 diabetes treatment in conventional medicinal practices. Taylor and Francis 2024-12-02 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114865/1/114865.pdf Adeyemi, Sherif Babatunde and Saliu, Ahmed Abiodun and Joshi, Bhrugesh Pravinchandra and Krishnamurthy, Ramar (2024) Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation. Egyptian Journal of Basic and Applied Sciences, 11 (1). pp. 719-742. ISSN 2314-808X; eISSN: 2314-808X https://www.tandfonline.com/doi/full/10.1080/2314808X.2024.2434995 10.1080/2314808X.2024.2434995
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The prevalence of diabetes mellitus is increasing, and well-known conventional medications are associated with harmful effects. Therefore, this study aimed to identify the compounds present in the young leaves of Daniellia oliveri and assess their antidiabetic potential using an in-silico model. The best column chromatographic fraction obtained from ethyl acetate fraction was analyzed using HRLC-MS to identify the prominent compounds. The identified compounds were subjected to ADMET prediction using online servers to confirm their draggability. In addition, the compounds were screened for activity against type 2 diabetes using molecular docking. Eight compounds with prominent peaks were identified, viz; gallic acid, 2,6-dihydroxybenzoic acid, salicylic acid, caffeic acid, phenylacetaldehyde, 2,5-dimethylphenol, 3-(−4-Hydroxyphenyl) propionic acid, and 16-hydroxyhexadecanoic acid. Most of the identified compounds were phenolics and had little toxic effects. The molecular docking results revealed the potentials of the identified compounds in inhibiting the therapeutic targets viz; 11β-hydroxysteroid dehydrogenase type 1, human salivary alpha-amylase, glycogen phosphorylase, human protein tyrosine phosphatase 1B, glutamine fructose-6-phosphate amidotransferase, human sirtuin 6, and dipeptidyl peptidase IV, responsible for the development of type 2 diabetes. This study has successfully revalidated and provided scientific insight into the usage of D. oliveri in managing type 2 diabetes by Nigerians. However, the limitation of this study remains the purification of the lead compounds that can serve as lead for type 2 diabetes treatment in conventional medicinal practices.
format Article
author Adeyemi, Sherif Babatunde
Saliu, Ahmed Abiodun
Joshi, Bhrugesh Pravinchandra
Krishnamurthy, Ramar
spellingShingle Adeyemi, Sherif Babatunde
Saliu, Ahmed Abiodun
Joshi, Bhrugesh Pravinchandra
Krishnamurthy, Ramar
Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
author_facet Adeyemi, Sherif Babatunde
Saliu, Ahmed Abiodun
Joshi, Bhrugesh Pravinchandra
Krishnamurthy, Ramar
author_sort Adeyemi, Sherif Babatunde
title Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
title_short Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
title_full Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
title_fullStr Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
title_full_unstemmed Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
title_sort daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation
publisher Taylor and Francis
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/114865/1/114865.pdf
http://psasir.upm.edu.my/id/eprint/114865/
https://www.tandfonline.com/doi/full/10.1080/2314808X.2024.2434995
_version_ 1823276371222200320
score 13.244413

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