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Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased af...

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Main Authors: Shamaan, Nor Aripin, Wan Ngah, Wan Zurinah, Ibrahim, Rusli, Jarien, Zanariah
Format: Article
Language:English
Published: 1993
Online Access:http://psasir.upm.edu.my/id/eprint/114818/1/114818.pdf
http://psasir.upm.edu.my/id/eprint/114818/
https://linkinghub.elsevier.com/retrieve/pii/000629529390052X
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spelling my.upm.eprints.1148182025-02-03T06:31:37Z http://psasir.upm.edu.my/id/eprint/114818/ Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene Shamaan, Nor Aripin Wan Ngah, Wan Zurinah Ibrahim, Rusli Jarien, Zanariah The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities. © 1993. 1993 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114818/1/114818.pdf Shamaan, Nor Aripin and Wan Ngah, Wan Zurinah and Ibrahim, Rusli and Jarien, Zanariah (1993) Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene. Biochemical Pharmacology, 45 (7). pp. 1517-1519. ISSN 0006-2952; eISSN: 0006-2952 https://linkinghub.elsevier.com/retrieve/pii/000629529390052X 10.1016/0006-2952(93)90052-X
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities. © 1993.
format Article
author Shamaan, Nor Aripin
Wan Ngah, Wan Zurinah
Ibrahim, Rusli
Jarien, Zanariah
spellingShingle Shamaan, Nor Aripin
Wan Ngah, Wan Zurinah
Ibrahim, Rusli
Jarien, Zanariah
Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
author_facet Shamaan, Nor Aripin
Wan Ngah, Wan Zurinah
Ibrahim, Rusli
Jarien, Zanariah
author_sort Shamaan, Nor Aripin
title Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
title_short Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
title_full Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
title_fullStr Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
title_full_unstemmed Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
title_sort effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene
publishDate 1993
url http://psasir.upm.edu.my/id/eprint/114818/1/114818.pdf
http://psasir.upm.edu.my/id/eprint/114818/
https://linkinghub.elsevier.com/retrieve/pii/000629529390052X
_version_ 1823093283859988480
score 13.244109

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