Staff View: A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer

A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer

Background/Objectives: Nuclear pleomorphism, a crucial determinant of breast cancer grading under the Nottingham Histopathology Grading (NHG) system, remains inadequately quantified in the existing literature. Motivated by this gap, our study seeks to investigate and establish correlations among mor...

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Main Authors:	Teoh, Chai Ling, Tan, Xiao Jian, Ab Rahman, Khairul Shakir, Bakrin, Ikmal Hisyam, Goh, Kam Meng, Siet, Joseph Jiun Wen, Wan Muhamad, Wan Zuki Azman
Format:	Article
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2024
Online Access:	http://psasir.upm.edu.my/id/eprint/114647/1/114647.pdf http://psasir.upm.edu.my/id/eprint/114647/ https://www.mdpi.com/2075-4418/14/18/2045
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spelling	my.upm.eprints.1146472025-01-22T06:58:49Z http://psasir.upm.edu.my/id/eprint/114647/ A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer Teoh, Chai Ling Tan, Xiao Jian Ab Rahman, Khairul Shakir Bakrin, Ikmal Hisyam Goh, Kam Meng Siet, Joseph Jiun Wen Wan Muhamad, Wan Zuki Azman Background/Objectives: Nuclear pleomorphism, a crucial determinant of breast cancer grading under the Nottingham Histopathology Grading (NHG) system, remains inadequately quantified in the existing literature. Motivated by this gap, our study seeks to investigate and establish correlations among morphological features across various scores of nuclear pleomorphism, as per the NHG system. We aim to quantify nuclear pleomorphism across these scores and validate our proposed measurement method against ground-truth data. Methods: Initially, we deconstruct the descriptions of nuclear pleomorphism into three core elements: size, shape, and appearance. These elements are subsequently mathematically modeled into equations, termed (Formula presented.), (Formula presented.), and (Formula presented.). These equations are then integrated into a unified model termed Harmonic Mean (HM). The HM equation yields a value approaching 1 for nuclei demonstrating characteristics of score-3 nuclear pleomorphism and near 0 for those exhibiting features of score-1 nuclear pleomorphism. Results: The proposed HM model demonstrates promising performance metrics, including Accuracy, Recall, Specificity, Precision, and F1-score, with values of 0.97, 0.96, 0.97, 0.94, and 0.95, respectively. Conclusions: In summary, this study proposes the HM equation as a novel feature for the precise quantification of nuclear pleomorphism in breast cancer. Multidisciplinary Digital Publishing Institute 2024-09-14 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/114647/1/114647.pdf Teoh, Chai Ling and Tan, Xiao Jian and Ab Rahman, Khairul Shakir and Bakrin, Ikmal Hisyam and Goh, Kam Meng and Siet, Joseph Jiun Wen and Wan Muhamad, Wan Zuki Azman (2024) A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer. Diagnostics, 14 (18). art. no. 2045. ISSN 2075-4418; eISSN: 2075-4418 https://www.mdpi.com/2075-4418/14/18/2045 10.3390/diagnostics14182045
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Background/Objectives: Nuclear pleomorphism, a crucial determinant of breast cancer grading under the Nottingham Histopathology Grading (NHG) system, remains inadequately quantified in the existing literature. Motivated by this gap, our study seeks to investigate and establish correlations among morphological features across various scores of nuclear pleomorphism, as per the NHG system. We aim to quantify nuclear pleomorphism across these scores and validate our proposed measurement method against ground-truth data. Methods: Initially, we deconstruct the descriptions of nuclear pleomorphism into three core elements: size, shape, and appearance. These elements are subsequently mathematically modeled into equations, termed (Formula presented.), (Formula presented.), and (Formula presented.). These equations are then integrated into a unified model termed Harmonic Mean (HM). The HM equation yields a value approaching 1 for nuclei demonstrating characteristics of score-3 nuclear pleomorphism and near 0 for those exhibiting features of score-1 nuclear pleomorphism. Results: The proposed HM model demonstrates promising performance metrics, including Accuracy, Recall, Specificity, Precision, and F1-score, with values of 0.97, 0.96, 0.97, 0.94, and 0.95, respectively. Conclusions: In summary, this study proposes the HM equation as a novel feature for the precise quantification of nuclear pleomorphism in breast cancer.
format	Article
author	Teoh, Chai Ling Tan, Xiao Jian Ab Rahman, Khairul Shakir Bakrin, Ikmal Hisyam Goh, Kam Meng Siet, Joseph Jiun Wen Wan Muhamad, Wan Zuki Azman
spellingShingle	Teoh, Chai Ling Tan, Xiao Jian Ab Rahman, Khairul Shakir Bakrin, Ikmal Hisyam Goh, Kam Meng Siet, Joseph Jiun Wen Wan Muhamad, Wan Zuki Azman A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
author_facet	Teoh, Chai Ling Tan, Xiao Jian Ab Rahman, Khairul Shakir Bakrin, Ikmal Hisyam Goh, Kam Meng Siet, Joseph Jiun Wen Wan Muhamad, Wan Zuki Azman
author_sort	Teoh, Chai Ling
title	A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
title_short	A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
title_full	A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
title_fullStr	A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
title_full_unstemmed	A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
title_sort	quantitative measurement method for nuclear-pleomorphism scoring in breast cancer
publisher	Multidisciplinary Digital Publishing Institute
publishDate	2024
url	http://psasir.upm.edu.my/id/eprint/114647/1/114647.pdf http://psasir.upm.edu.my/id/eprint/114647/ https://www.mdpi.com/2075-4418/14/18/2045
_version_	1823093218072330240
score	13.23648

A quantitative measurement method for nuclear-pleomorphism scoring in breast cancer

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