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Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract

Radix Glycyrrhizae, the dried roots of the Glycyrrhiza glabra plant, is a popular Chinese herbal medicine known for its various health benefits. It is particularly effective in relieving respiratory problems like coughs, sore throats, bronchitis, and asthma. However, there is limited research on the...

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Main Authors: Hong Liang, Ong, Ee Meng, Cheng, Mohamad, Che Wan Sharifah Robiah, Mohd Nasir, Nashrul Fazli, Xiao Jian, Tan, Chong You, Beh, Ziezie Mohd Tarmizi, Emma, Kim Yee, Lee, Kok Yeow, You, Shing Fhan, Khor, Kim Fey, Leu, Kian Keong, Te, Mohd Roslan, Mohd Riza, Baharuddin, Siti Aishah
Format: Article
Language:English
Published: Elsevier 2024
Online Access:http://psasir.upm.edu.my/id/eprint/114546/1/114546.pdf
http://psasir.upm.edu.my/id/eprint/114546/
https://linkinghub.elsevier.com/retrieve/pii/S2405844024131088
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spelling my.upm.eprints.1145462025-01-17T07:41:49Z http://psasir.upm.edu.my/id/eprint/114546/ Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract Hong Liang, Ong Ee Meng, Cheng Mohamad, Che Wan Sharifah Robiah Mohd Nasir, Nashrul Fazli Xiao Jian, Tan Chong You, Beh Ziezie Mohd Tarmizi, Emma Kim Yee, Lee Kok Yeow, You Shing Fhan, Khor Kim Fey, Leu Kian Keong, Te Mohd Roslan, Mohd Riza Baharuddin, Siti Aishah Radix Glycyrrhizae, the dried roots of the Glycyrrhiza glabra plant, is a popular Chinese herbal medicine known for its various health benefits. It is particularly effective in relieving respiratory problems like coughs, sore throats, bronchitis, and asthma. However, there is limited research on the electrical properties of Radix Glycyrrhizae, likely due to its complex composition of phytochemical and antioxidant activities. This research aims to investigate the potential of these active biological compounds and understand their electrochemical properties. In this study, High-Performance Liquid Chromatography (HPLC) analysis revealed that Radix Glycyrrhizae decoction contains significant amounts of flavonoids and saponins, compounds known for their health benefits and therapeutic effects. Further analysis using Fourier Transform Infrared Spectroscopy (FTIR) identified several functional groups, including phenols, alcohols, alkynes, alkenes, ethers, and glycosides, which contribute to the plant's medicinal potential and affect the impedance and dielectric properties of the extract. The antioxidant activity of Radix Glycyrrhizae decoction was also evaluated using DPPH assays, showing similar radical scavenging activity to gallic acid. Dielectric and impedance measurement of Radix Glycyrrhizae extract were performed using an Agilent vector network analyzer and a Hioki impedance analyzer. The dielectric constant measured was consistent across both analyzers. However, the loss factor showed different trends: the vector network analyzer indicated a decrease in the loss factor with increasing frequency in the range of 5 MHz–20 GHz, while the impedance analyzer showed the opposite trend in the frequency range of 4 Hz–5 MHz. Elsevier 2024 Article PeerReviewed text en cc_by_nc_4 http://psasir.upm.edu.my/id/eprint/114546/1/114546.pdf Hong Liang, Ong and Ee Meng, Cheng and Mohamad, Che Wan Sharifah Robiah and Mohd Nasir, Nashrul Fazli and Xiao Jian, Tan and Chong You, Beh and Ziezie Mohd Tarmizi, Emma and Kim Yee, Lee and Kok Yeow, You and Shing Fhan, Khor and Kim Fey, Leu and Kian Keong, Te and Mohd Roslan, Mohd Riza and Baharuddin, Siti Aishah (2024) Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract. Heliyon, 10 (17). art. no. e37077. pp. 1-10. ISSN 2405-8440; eISSN: 2405-8440 https://linkinghub.elsevier.com/retrieve/pii/S2405844024131088 10.1016/j.heliyon.2024.e37077
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Radix Glycyrrhizae, the dried roots of the Glycyrrhiza glabra plant, is a popular Chinese herbal medicine known for its various health benefits. It is particularly effective in relieving respiratory problems like coughs, sore throats, bronchitis, and asthma. However, there is limited research on the electrical properties of Radix Glycyrrhizae, likely due to its complex composition of phytochemical and antioxidant activities. This research aims to investigate the potential of these active biological compounds and understand their electrochemical properties. In this study, High-Performance Liquid Chromatography (HPLC) analysis revealed that Radix Glycyrrhizae decoction contains significant amounts of flavonoids and saponins, compounds known for their health benefits and therapeutic effects. Further analysis using Fourier Transform Infrared Spectroscopy (FTIR) identified several functional groups, including phenols, alcohols, alkynes, alkenes, ethers, and glycosides, which contribute to the plant's medicinal potential and affect the impedance and dielectric properties of the extract. The antioxidant activity of Radix Glycyrrhizae decoction was also evaluated using DPPH assays, showing similar radical scavenging activity to gallic acid. Dielectric and impedance measurement of Radix Glycyrrhizae extract were performed using an Agilent vector network analyzer and a Hioki impedance analyzer. The dielectric constant measured was consistent across both analyzers. However, the loss factor showed different trends: the vector network analyzer indicated a decrease in the loss factor with increasing frequency in the range of 5 MHz–20 GHz, while the impedance analyzer showed the opposite trend in the frequency range of 4 Hz–5 MHz.
format Article
author Hong Liang, Ong
Ee Meng, Cheng
Mohamad, Che Wan Sharifah Robiah
Mohd Nasir, Nashrul Fazli
Xiao Jian, Tan
Chong You, Beh
Ziezie Mohd Tarmizi, Emma
Kim Yee, Lee
Kok Yeow, You
Shing Fhan, Khor
Kim Fey, Leu
Kian Keong, Te
Mohd Roslan, Mohd Riza
Baharuddin, Siti Aishah
spellingShingle Hong Liang, Ong
Ee Meng, Cheng
Mohamad, Che Wan Sharifah Robiah
Mohd Nasir, Nashrul Fazli
Xiao Jian, Tan
Chong You, Beh
Ziezie Mohd Tarmizi, Emma
Kim Yee, Lee
Kok Yeow, You
Shing Fhan, Khor
Kim Fey, Leu
Kian Keong, Te
Mohd Roslan, Mohd Riza
Baharuddin, Siti Aishah
Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract
author_facet Hong Liang, Ong
Ee Meng, Cheng
Mohamad, Che Wan Sharifah Robiah
Mohd Nasir, Nashrul Fazli
Xiao Jian, Tan
Chong You, Beh
Ziezie Mohd Tarmizi, Emma
Kim Yee, Lee
Kok Yeow, You
Shing Fhan, Khor
Kim Fey, Leu
Kian Keong, Te
Mohd Roslan, Mohd Riza
Baharuddin, Siti Aishah
author_sort Hong Liang, Ong
title Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract
title_short Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract
title_full Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract
title_fullStr Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract
title_full_unstemmed Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract
title_sort frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in radix glycyrrhizae extract
publisher Elsevier
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/114546/1/114546.pdf
http://psasir.upm.edu.my/id/eprint/114546/
https://linkinghub.elsevier.com/retrieve/pii/S2405844024131088
_version_ 1823093199517777920
score 13.244413

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