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Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel

Celecoxib (CXB) is a lipophilic drug with limited solubility in water and reduced oral bioavailability. Nanoemulgel (NEG) is a promising transdermal delivery system that improves the solubility and bioavailability of poorly water-soluble drugs compared to oral administration. Therefore, this study a...

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Main Authors: Hairul, Nuriana Munirah, Anuar, Nor Khaizan, Zulfakar, Mohd Hanif, Salim, Norazlinaliza, Ibrahim, Salizatul Ilyana
Format: Article
Language:English
Published: Malaysian Institute of Chemistry 2024
Online Access:http://psasir.upm.edu.my/id/eprint/114456/1/114456.pdf
http://psasir.upm.edu.my/id/eprint/114456/
https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0052-87688f7
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spelling my.upm.eprints.1144562025-01-16T08:19:09Z http://psasir.upm.edu.my/id/eprint/114456/ Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel Hairul, Nuriana Munirah Anuar, Nor Khaizan Zulfakar, Mohd Hanif Salim, Norazlinaliza Ibrahim, Salizatul Ilyana Celecoxib (CXB) is a lipophilic drug with limited solubility in water and reduced oral bioavailability. Nanoemulgel (NEG) is a promising transdermal delivery system that improves the solubility and bioavailability of poorly water-soluble drugs compared to oral administration. Therefore, this study aimed to develop and characterize a transdermal NEG formulation for CXB, utilizing fractionated medium-chain triglycerides (FMCTs) oils as carrier oils. FMCTs oils, derived from palm kernel oil (Elaeis guineensis), are known for their ability to enhance the solubility of lipophilic drugs, making them an appealing choice for this application. The study began by selecting carrier oils - caprylic capric triglyceride (MCT) and a blend with palm kernel olein (PKOlein) based on solubility tests. Phase diagrams were constructed to determine the optimal concentrations for formulating the nanoemulsion (NE). Various NE formulations were prepared using the low-energy emulsification method, followed by formulating corresponding nanoemulgel (NEG) by incorporating Carbopol 940 in varying concentrations. The developed NEs and NEG exhibited the droplet size range between 26.75 and 55.87 nm with the zeta potential values within -22.47 to -38.83 mV and the PDI values less than 0.5, whereas the morphology showed a well-identified spherical particle. Two formulations named NEG-F14 0.5% and NEG-F17 0.5% were selected for further study on the drug content, EE% and in-vitro drug release. Results showed that NEG-F17 0.5% had a higher drug content (97.54%) with 83.39% of EE when compared with NEG-F15 0.5%. The drug release study shows that NEGF17 0.5% was remarkably higher as compared to NEG-F14 0.5%, due to the presence of PKOlein in nanoemulsion which improve the solubility, decrease particle size, thus increasing the penetration of CXB. These findings collectively suggest that the developed NEs and NEGs offered desirable attributes for their potential in transdermal drug delivery. Malaysian Institute of Chemistry 2024-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114456/1/114456.pdf Hairul, Nuriana Munirah and Anuar, Nor Khaizan and Zulfakar, Mohd Hanif and Salim, Norazlinaliza and Ibrahim, Salizatul Ilyana (2024) Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel. Malaysian Journal of Chemistry, 26 (5). pp. 442-454. ISSN 1511-2292; eISSN: 2550-1658 https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0052-87688f7 10.55373/mjchem.v26i5.442
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Celecoxib (CXB) is a lipophilic drug with limited solubility in water and reduced oral bioavailability. Nanoemulgel (NEG) is a promising transdermal delivery system that improves the solubility and bioavailability of poorly water-soluble drugs compared to oral administration. Therefore, this study aimed to develop and characterize a transdermal NEG formulation for CXB, utilizing fractionated medium-chain triglycerides (FMCTs) oils as carrier oils. FMCTs oils, derived from palm kernel oil (Elaeis guineensis), are known for their ability to enhance the solubility of lipophilic drugs, making them an appealing choice for this application. The study began by selecting carrier oils - caprylic capric triglyceride (MCT) and a blend with palm kernel olein (PKOlein) based on solubility tests. Phase diagrams were constructed to determine the optimal concentrations for formulating the nanoemulsion (NE). Various NE formulations were prepared using the low-energy emulsification method, followed by formulating corresponding nanoemulgel (NEG) by incorporating Carbopol 940 in varying concentrations. The developed NEs and NEG exhibited the droplet size range between 26.75 and 55.87 nm with the zeta potential values within -22.47 to -38.83 mV and the PDI values less than 0.5, whereas the morphology showed a well-identified spherical particle. Two formulations named NEG-F14 0.5% and NEG-F17 0.5% were selected for further study on the drug content, EE% and in-vitro drug release. Results showed that NEG-F17 0.5% had a higher drug content (97.54%) with 83.39% of EE when compared with NEG-F15 0.5%. The drug release study shows that NEGF17 0.5% was remarkably higher as compared to NEG-F14 0.5%, due to the presence of PKOlein in nanoemulsion which improve the solubility, decrease particle size, thus increasing the penetration of CXB. These findings collectively suggest that the developed NEs and NEGs offered desirable attributes for their potential in transdermal drug delivery.
format Article
author Hairul, Nuriana Munirah
Anuar, Nor Khaizan
Zulfakar, Mohd Hanif
Salim, Norazlinaliza
Ibrahim, Salizatul Ilyana
spellingShingle Hairul, Nuriana Munirah
Anuar, Nor Khaizan
Zulfakar, Mohd Hanif
Salim, Norazlinaliza
Ibrahim, Salizatul Ilyana
Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
author_facet Hairul, Nuriana Munirah
Anuar, Nor Khaizan
Zulfakar, Mohd Hanif
Salim, Norazlinaliza
Ibrahim, Salizatul Ilyana
author_sort Hairul, Nuriana Munirah
title Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
title_short Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
title_full Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
title_fullStr Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
title_full_unstemmed Formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
title_sort formulation and characterization of celecoxib-loaded fractionated medium chain triglycerides oil based nanoemulgel
publisher Malaysian Institute of Chemistry
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/114456/1/114456.pdf
http://psasir.upm.edu.my/id/eprint/114456/
https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0052-87688f7
_version_ 1823093159949762560
score 13.244413

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