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Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats

Andrographis paniculata (Burm.f.) Nees has been used traditionally in treating many diseases. This study investigated its potential to attenuate benign prostatic hyperplasia (BPH) in male rats. Rats were castrated, divided into five groups and orally treated for 14 days with: normal saline,10 mg/kg...

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Main Authors: Etti, Imaobong Christopher, Unoh, Erimimoh Eba, Akpan, Mary Richard, Umanah, Ubong Uduak, Agbonika, Rebecca Emmanuel, Kadir, Arifah Abdul, Nwafor, Chukwuemeka
Format: Article
Published: Taylor and Francis 2024
Online Access:http://psasir.upm.edu.my/id/eprint/114346/
https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2401494
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spelling my.upm.eprints.1143462025-01-14T06:36:57Z http://psasir.upm.edu.my/id/eprint/114346/ Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats Etti, Imaobong Christopher Unoh, Erimimoh Eba Akpan, Mary Richard Umanah, Ubong Uduak Agbonika, Rebecca Emmanuel Kadir, Arifah Abdul Nwafor, Chukwuemeka Andrographis paniculata (Burm.f.) Nees has been used traditionally in treating many diseases. This study investigated its potential to attenuate benign prostatic hyperplasia (BPH) in male rats. Rats were castrated, divided into five groups and orally treated for 14 days with: normal saline,10 mg/kg testosterone propionate sc, finasteride (0.5 mg/kg), 500 mg, and 1500 mg/kg of Andrographis paniculata. Relative prostate weights, the correlation between prostatic index and volume and the prostates’ histopathology as well as Prostate Specific Antigen (PSA) were evaluated. Following treatment with Andrographis paniculata, the prostate weights were significantly reduced (p < 0.05) and the lost correlation observed in the untreated group was restored. Histopathological assessment showed reduced epithelial hyperplasia following treatment with a resultant thin layer of epithelial cells, similar to the healthy normal control group. The level of PSA was also reduced. Andrographis paniculata, thus, has the potential to inhibit the proliferation observed in testosterone-induced BPH. Taylor and Francis 2024-09-12 Article PeerReviewed Etti, Imaobong Christopher and Unoh, Erimimoh Eba and Akpan, Mary Richard and Umanah, Ubong Uduak and Agbonika, Rebecca Emmanuel and Kadir, Arifah Abdul and Nwafor, Chukwuemeka (2024) Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats. Natural Product Research. pp. 1-9. ISSN 1478-6419; eISSN: 1478-6427 https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2401494 10.1080/14786419.2024.2401494
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Andrographis paniculata (Burm.f.) Nees has been used traditionally in treating many diseases. This study investigated its potential to attenuate benign prostatic hyperplasia (BPH) in male rats. Rats were castrated, divided into five groups and orally treated for 14 days with: normal saline,10 mg/kg testosterone propionate sc, finasteride (0.5 mg/kg), 500 mg, and 1500 mg/kg of Andrographis paniculata. Relative prostate weights, the correlation between prostatic index and volume and the prostates’ histopathology as well as Prostate Specific Antigen (PSA) were evaluated. Following treatment with Andrographis paniculata, the prostate weights were significantly reduced (p < 0.05) and the lost correlation observed in the untreated group was restored. Histopathological assessment showed reduced epithelial hyperplasia following treatment with a resultant thin layer of epithelial cells, similar to the healthy normal control group. The level of PSA was also reduced. Andrographis paniculata, thus, has the potential to inhibit the proliferation observed in testosterone-induced BPH.
format Article
author Etti, Imaobong Christopher
Unoh, Erimimoh Eba
Akpan, Mary Richard
Umanah, Ubong Uduak
Agbonika, Rebecca Emmanuel
Kadir, Arifah Abdul
Nwafor, Chukwuemeka
spellingShingle Etti, Imaobong Christopher
Unoh, Erimimoh Eba
Akpan, Mary Richard
Umanah, Ubong Uduak
Agbonika, Rebecca Emmanuel
Kadir, Arifah Abdul
Nwafor, Chukwuemeka
Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
author_facet Etti, Imaobong Christopher
Unoh, Erimimoh Eba
Akpan, Mary Richard
Umanah, Ubong Uduak
Agbonika, Rebecca Emmanuel
Kadir, Arifah Abdul
Nwafor, Chukwuemeka
author_sort Etti, Imaobong Christopher
title Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
title_short Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
title_full Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
title_fullStr Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
title_full_unstemmed Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
title_sort attenuation of testosterone-induced benign prostatic hyperplasia with andrographis paniculata (burm.f.) leaf extract in wistar rats
publisher Taylor and Francis
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/114346/
https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2401494
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score 13.244413

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