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Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study

Patients with peripheral neuropathy could have damaged peripheral nerves, which leads to sensory and motor dysfunction. Diabetes, infections, and trauma are the major causes of peripheral neuropathy. Vibratory perception threshold (VPT) tools are commonly used to detect peripheral neuropathy. This s...

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Main Authors: Mooi, Ching Siew, Lee, Kai Wei, Yusof Khan, Abdul Hanif Khan, Devaraj, Navin Kumar, Cheong, Ai Theng, Hoo, Fan Kee, Sulaiman, Wan Aliaa Wan, Loh, Wei Chao, Jian, Leong Yong, Hui, Teh Xian, Ramachandran, Vasudevan
Format: Article
Language:English
Published: Hamad Bin Khalifa University Press 2024
Online Access:http://psasir.upm.edu.my/id/eprint/114284/1/114284.pdf
http://psasir.upm.edu.my/id/eprint/114284/
https://www.qscience.com/content/journals/10.5339/qmj.2024.24
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spelling my.upm.eprints.1142842025-01-13T07:11:03Z http://psasir.upm.edu.my/id/eprint/114284/ Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study Mooi, Ching Siew Lee, Kai Wei Yusof Khan, Abdul Hanif Khan Devaraj, Navin Kumar Cheong, Ai Theng Hoo, Fan Kee Sulaiman, Wan Aliaa Wan Loh, Wei Chao Jian, Leong Yong Hui, Teh Xian Ramachandran, Vasudevan Patients with peripheral neuropathy could have damaged peripheral nerves, which leads to sensory and motor dysfunction. Diabetes, infections, and trauma are the major causes of peripheral neuropathy. Vibratory perception threshold (VPT) tools are commonly used to detect peripheral neuropathy. This study aims to determine the assessment of peripheral neuropathy through the different diagnostic tools in the community in Malaysia. A total number of 1283 participants were recruited from the seven retail pharmacies located in Selangor, Malaysia. The peripheral neuropathy test was conducted based on VPT tools on both feet using the digital biothesiometer. Following that, Neurological Symptom Score (NSS) and Neurological Disability Score (NDS) were taken from the participants to assess the neurological symptoms. Participants had an average age of 40.6 ± 12.9 years and were mostly of Chinese ethnicity (54.1%). The findings show that increasing age was associated with more severe peripheral neuropathy across the various assessment tools, but gender differences were found with the biothesiometer test and ethnicity has severity in the biothesiometer and disability scores. The sensitivity and specificity of the biothesiometer test were 0.63 and 0.84, respectively. The combined tool NSS and NDS had high specificity and a high positive predictive value, suggesting that it could be a reliable indicator of peripheral neuropathy when both scores are elevated. The findings show that the biothesiometer test, NSS, and NDS are considered screening VPT tools for diagnosing peripheral neuropathy. However, further evaluation and diagnostic testing are necessary in cases of a positive test result. Hamad Bin Khalifa University Press 2024-08-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114284/1/114284.pdf Mooi, Ching Siew and Lee, Kai Wei and Yusof Khan, Abdul Hanif Khan and Devaraj, Navin Kumar and Cheong, Ai Theng and Hoo, Fan Kee and Sulaiman, Wan Aliaa Wan and Loh, Wei Chao and Jian, Leong Yong and Hui, Teh Xian and Ramachandran, Vasudevan (2024) Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study. Qatar Medical Journal, 2024 (3). art. no. 24. ISSN 0253-8253; eISSN: 2227-0426 https://www.qscience.com/content/journals/10.5339/qmj.2024.24 10.5339/qmj.2024.24
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Patients with peripheral neuropathy could have damaged peripheral nerves, which leads to sensory and motor dysfunction. Diabetes, infections, and trauma are the major causes of peripheral neuropathy. Vibratory perception threshold (VPT) tools are commonly used to detect peripheral neuropathy. This study aims to determine the assessment of peripheral neuropathy through the different diagnostic tools in the community in Malaysia. A total number of 1283 participants were recruited from the seven retail pharmacies located in Selangor, Malaysia. The peripheral neuropathy test was conducted based on VPT tools on both feet using the digital biothesiometer. Following that, Neurological Symptom Score (NSS) and Neurological Disability Score (NDS) were taken from the participants to assess the neurological symptoms. Participants had an average age of 40.6 ± 12.9 years and were mostly of Chinese ethnicity (54.1%). The findings show that increasing age was associated with more severe peripheral neuropathy across the various assessment tools, but gender differences were found with the biothesiometer test and ethnicity has severity in the biothesiometer and disability scores. The sensitivity and specificity of the biothesiometer test were 0.63 and 0.84, respectively. The combined tool NSS and NDS had high specificity and a high positive predictive value, suggesting that it could be a reliable indicator of peripheral neuropathy when both scores are elevated. The findings show that the biothesiometer test, NSS, and NDS are considered screening VPT tools for diagnosing peripheral neuropathy. However, further evaluation and diagnostic testing are necessary in cases of a positive test result.
format Article
author Mooi, Ching Siew
Lee, Kai Wei
Yusof Khan, Abdul Hanif Khan
Devaraj, Navin Kumar
Cheong, Ai Theng
Hoo, Fan Kee
Sulaiman, Wan Aliaa Wan
Loh, Wei Chao
Jian, Leong Yong
Hui, Teh Xian
Ramachandran, Vasudevan
spellingShingle Mooi, Ching Siew
Lee, Kai Wei
Yusof Khan, Abdul Hanif Khan
Devaraj, Navin Kumar
Cheong, Ai Theng
Hoo, Fan Kee
Sulaiman, Wan Aliaa Wan
Loh, Wei Chao
Jian, Leong Yong
Hui, Teh Xian
Ramachandran, Vasudevan
Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
author_facet Mooi, Ching Siew
Lee, Kai Wei
Yusof Khan, Abdul Hanif Khan
Devaraj, Navin Kumar
Cheong, Ai Theng
Hoo, Fan Kee
Sulaiman, Wan Aliaa Wan
Loh, Wei Chao
Jian, Leong Yong
Hui, Teh Xian
Ramachandran, Vasudevan
author_sort Mooi, Ching Siew
title Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
title_short Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
title_full Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
title_fullStr Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
title_full_unstemmed Using biothesiometer, Neuropathy Symptom Score, and Neuropathy Disability Score for the early detection of peripheral neuropathy: a cross-sectional study
title_sort using biothesiometer, neuropathy symptom score, and neuropathy disability score for the early detection of peripheral neuropathy: a cross-sectional study
publisher Hamad Bin Khalifa University Press
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/114284/1/114284.pdf
http://psasir.upm.edu.my/id/eprint/114284/
https://www.qscience.com/content/journals/10.5339/qmj.2024.24
_version_ 1823093104365797376
score 13.23648

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