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Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat

The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, a...

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Main Authors: Rahmat, Asmah, Wan Ngah, Wan Zurinah, Jarien, Zanariah, Ismail, Rosnani, Marzuki, Alini, Abdul Kadir, Khalid, Shamaan, Nor Aripin
Format: Article
Language:English
Published: The Society for Free Radical Research Japan 1993
Online Access:http://psasir.upm.edu.my/id/eprint/114031/1/114031.pdf
http://psasir.upm.edu.my/id/eprint/114031/
https://www.jstage.jst.go.jp/article/jcbn1986/15/3/15_3_195/_article
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spelling my.upm.eprints.1140312024-12-08T08:04:24Z http://psasir.upm.edu.my/id/eprint/114031/ Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat Rahmat, Asmah Wan Ngah, Wan Zurinah Jarien, Zanariah Ismail, Rosnani Marzuki, Alini Abdul Kadir, Khalid Shamaan, Nor Aripin The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, and blood glutathione (GSH). Rats treated with DEN/AAF had significantly elevated plasma and microsomal GGT, plasma ALP activities, and blood GSH levels compared with the normal controls (Ρ<0.05). Supplementation with vitamin E of normal controls did not affect the enzyme activities or blood GSH. in rats treated with DEN/AAF, vitamin E supplementation attenuated GGT and ALP activitiesand blood GSH levels. the optimum dose required for highest attenuation of the tumor marker enzyme activities was 34 mg/kg diet for α-tocopherol and 30 mg/kg diet for y-tocotrienol. Higher doses of the vitamin did not show further attenuation in the level of the tumor marker enzyme activities. The Society for Free Radical Research Japan 1993 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/114031/1/114031.pdf Rahmat, Asmah and Wan Ngah, Wan Zurinah and Jarien, Zanariah and Ismail, Rosnani and Marzuki, Alini and Abdul Kadir, Khalid and Shamaan, Nor Aripin (1993) Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat. Journal of Clinical Biochemistry and Nutrition, 15 (3). pp. 195-202. ISSN 0912-0009; eISSN: 1880-5086 https://www.jstage.jst.go.jp/article/jcbn1986/15/3/15_3_195/_article 10.3164/jcbn.15.195
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, and blood glutathione (GSH). Rats treated with DEN/AAF had significantly elevated plasma and microsomal GGT, plasma ALP activities, and blood GSH levels compared with the normal controls (Ρ<0.05). Supplementation with vitamin E of normal controls did not affect the enzyme activities or blood GSH. in rats treated with DEN/AAF, vitamin E supplementation attenuated GGT and ALP activitiesand blood GSH levels. the optimum dose required for highest attenuation of the tumor marker enzyme activities was 34 mg/kg diet for α-tocopherol and 30 mg/kg diet for y-tocotrienol. Higher doses of the vitamin did not show further attenuation in the level of the tumor marker enzyme activities.
format Article
author Rahmat, Asmah
Wan Ngah, Wan Zurinah
Jarien, Zanariah
Ismail, Rosnani
Marzuki, Alini
Abdul Kadir, Khalid
Shamaan, Nor Aripin
spellingShingle Rahmat, Asmah
Wan Ngah, Wan Zurinah
Jarien, Zanariah
Ismail, Rosnani
Marzuki, Alini
Abdul Kadir, Khalid
Shamaan, Nor Aripin
Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
author_facet Rahmat, Asmah
Wan Ngah, Wan Zurinah
Jarien, Zanariah
Ismail, Rosnani
Marzuki, Alini
Abdul Kadir, Khalid
Shamaan, Nor Aripin
author_sort Rahmat, Asmah
title Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
title_short Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
title_full Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
title_fullStr Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
title_full_unstemmed Effect of γ-Tocotrienol and α-Tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
title_sort effect of γ-tocotrienol and α-tocopherol on blood glutathione and tumor marker enzymes during chemical hepatocarcinogenesis in the rat
publisher The Society for Free Radical Research Japan
publishDate 1993
url http://psasir.upm.edu.my/id/eprint/114031/1/114031.pdf
http://psasir.upm.edu.my/id/eprint/114031/
https://www.jstage.jst.go.jp/article/jcbn1986/15/3/15_3_195/_article
_version_ 1818835914352230400
score 13.240574

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