Cover Image

GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation

This study reports the comparative evaluation of yield, physico-chemical composition and biological attributes (antioxidant activity, antimicrobial activity, biofilm inhibition and hemolytic activity) of peppermint (Mentha piperita L.) essential oil (EO) obtained by hydro-distillation (HD) and super...

Full description

Saved in:
Bibliographic Details
Main Authors: Abbas, Ali, Anwar, Farooq, Ahmad, Naveed, Rehman, Afifa tur, Mohammed, Osama A., Abdel-Reheim, Mustafa Ahmed, Iqbal, Munawar, Iqbal, Shahid, Nazir, Arif
Format: Article
Language:English
Published: Elsevier Ltd 2024
Online Access:http://psasir.upm.edu.my/id/eprint/113839/1/113839.pdf
http://psasir.upm.edu.my/id/eprint/113839/
https://linkinghub.elsevier.com/retrieve/pii/S2405844024113138
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.113839
record_format eprints
spelling my.upm.eprints.1138392025-01-20T01:46:36Z http://psasir.upm.edu.my/id/eprint/113839/ GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation Abbas, Ali Anwar, Farooq Ahmad, Naveed Rehman, Afifa tur Mohammed, Osama A. Abdel-Reheim, Mustafa Ahmed Iqbal, Munawar Iqbal, Shahid Nazir, Arif This study reports the comparative evaluation of yield, physico-chemical composition and biological attributes (antioxidant activity, antimicrobial activity, biofilm inhibition and hemolytic activity) of peppermint (Mentha piperita L.) essential oil (EO) obtained by hydro-distillation (HD) and supercritical fluid (CO2) extraction (SCFE) methods. The yield (%) of EO obtained by HD (0.20 %) was significantly (p < 0.05) higher than that of SCFE (0.13 %) while the variation in the physical parameters like solubility, color, density (at 25 °C) and refractive index (at 25 °C) was not significant between the tested oils. The data of chemical compositional analysis revealed that menthol was the key component in the EO obtained by HD (52.85 %) and SCFE (45.51 %), followed by menthone [HD (25.93 %) and SCFE (27.3 %)] and eucalyptol [HD (8.59 %); SCFE (8.92 %)]. The EO extracted with supercritical fluid (SCFE-EO) exhibited superior (p < 0.05) DPPH free radical inhibition potential (52 %) with an IC50 value of 15.65 μg/mL and reducing power compared to that of HD-EO. The highest antimicrobial activity was exhibited by SCFE-EO against Pasturella multocida with an inhibition zone of 18.00 mm (MIC value of 86 μg/mL). The results of biofilm inhibition and hemolytic activity revealed that the SCFE method was superior to recover high quality EO in comparison to the HD method. The peppermint EO obtained by SCFE, owing to potent bioactive components, can be a potential candidate to develop nutra-pharmaceuticals. Elsevier Ltd 2024-08-30 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/113839/1/113839.pdf Abbas, Ali and Anwar, Farooq and Ahmad, Naveed and Rehman, Afifa tur and Mohammed, Osama A. and Abdel-Reheim, Mustafa Ahmed and Iqbal, Munawar and Iqbal, Shahid and Nazir, Arif (2024) GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation. Heliyon, 10 (16). art. no. e35282. pp. 1-9. ISSN 2405-8440; eISSN: 2405-8440 https://linkinghub.elsevier.com/retrieve/pii/S2405844024113138 10.1016/j.heliyon.2024.e35282
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This study reports the comparative evaluation of yield, physico-chemical composition and biological attributes (antioxidant activity, antimicrobial activity, biofilm inhibition and hemolytic activity) of peppermint (Mentha piperita L.) essential oil (EO) obtained by hydro-distillation (HD) and supercritical fluid (CO2) extraction (SCFE) methods. The yield (%) of EO obtained by HD (0.20 %) was significantly (p < 0.05) higher than that of SCFE (0.13 %) while the variation in the physical parameters like solubility, color, density (at 25 °C) and refractive index (at 25 °C) was not significant between the tested oils. The data of chemical compositional analysis revealed that menthol was the key component in the EO obtained by HD (52.85 %) and SCFE (45.51 %), followed by menthone [HD (25.93 %) and SCFE (27.3 %)] and eucalyptol [HD (8.59 %); SCFE (8.92 %)]. The EO extracted with supercritical fluid (SCFE-EO) exhibited superior (p < 0.05) DPPH free radical inhibition potential (52 %) with an IC50 value of 15.65 μg/mL and reducing power compared to that of HD-EO. The highest antimicrobial activity was exhibited by SCFE-EO against Pasturella multocida with an inhibition zone of 18.00 mm (MIC value of 86 μg/mL). The results of biofilm inhibition and hemolytic activity revealed that the SCFE method was superior to recover high quality EO in comparison to the HD method. The peppermint EO obtained by SCFE, owing to potent bioactive components, can be a potential candidate to develop nutra-pharmaceuticals.
format Article
author Abbas, Ali
Anwar, Farooq
Ahmad, Naveed
Rehman, Afifa tur
Mohammed, Osama A.
Abdel-Reheim, Mustafa Ahmed
Iqbal, Munawar
Iqbal, Shahid
Nazir, Arif
spellingShingle Abbas, Ali
Anwar, Farooq
Ahmad, Naveed
Rehman, Afifa tur
Mohammed, Osama A.
Abdel-Reheim, Mustafa Ahmed
Iqbal, Munawar
Iqbal, Shahid
Nazir, Arif
GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
author_facet Abbas, Ali
Anwar, Farooq
Ahmad, Naveed
Rehman, Afifa tur
Mohammed, Osama A.
Abdel-Reheim, Mustafa Ahmed
Iqbal, Munawar
Iqbal, Shahid
Nazir, Arif
author_sort Abbas, Ali
title GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
title_short GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
title_full GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
title_fullStr GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
title_full_unstemmed GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
title_sort gc-ms analysis and nutra-pharmaceutical potential of mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation
publisher Elsevier Ltd
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/113839/1/113839.pdf
http://psasir.upm.edu.my/id/eprint/113839/
https://linkinghub.elsevier.com/retrieve/pii/S2405844024113138
_version_ 1823093076373012480
score 13.235796

Similar Items