Staff View: The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers

The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers

Background: This study investigated whether the Combat compensation method can remove the variability of radiomic features extracted from different scanners, while also examining its impact on the subsequent predictive performance of machine learning models. Materials and methods: 135 CT images of C...

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Main Authors:	Zhang, Xiaolei, Iqbal bin Saripan, M., Wu, Yanjun, Wang, Zhongxiao, Wen, Dong, Cao, Zhendong, Wang, Bingzhen, Xu, Shiqi, Liu, Yanli, Marhaban, Mohammad Hamiruce, Dong, Xianling
Format:	Article
Language:	English
Published:	BioMed Central 2024
Online Access:	http://psasir.upm.edu.my/id/eprint/113473/1/113473.pdf http://psasir.upm.edu.my/id/eprint/113473/ https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12880-024-01306-4
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spelling	my.upm.eprints.1134732024-11-25T07:08:31Z http://psasir.upm.edu.my/id/eprint/113473/ The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers Zhang, Xiaolei Iqbal bin Saripan, M. Wu, Yanjun Wang, Zhongxiao Wen, Dong Cao, Zhendong Wang, Bingzhen Xu, Shiqi Liu, Yanli Marhaban, Mohammad Hamiruce Dong, Xianling Background: This study investigated whether the Combat compensation method can remove the variability of radiomic features extracted from different scanners, while also examining its impact on the subsequent predictive performance of machine learning models. Materials and methods: 135 CT images of Credence Cartridge Radiomic phantoms were collected and screened from three scanners manufactured by Siemens, Philips, and GE. 100 radiomic features were extracted and 20 radiomic features were screened according to the Lasso regression method. The radiomic features extracted from the rubber and resin-filled regions in the cartridges were labeled into different categories for evaluating the performance of the machine learning model. Radiomics features were divided into three groups based on the different scanner manufacturers. The radiomic features were randomly divided into training and test sets with a ratio of 8:2. Five machine learning models (lasso, logistic regression, random forest, support vector machine, neural network) were employed to evaluate the impact of Combat on radiomic features. The variability among radiomic features were assessed using analysis of variance (ANOVA) and principal component analysis (PCA). Accuracy, precision, recall, and area under the receiver curve (AUC) were used as evaluation metrics for model classification. Results: The principal component and ANOVA analysis results show that the variability of different scanner manufacturers in radiomic features was removed (P˃0.05). After harmonization with the Combat algorithm, the distributions of radiomic features were aligned in terms of location and scale. The performance of machine learning models for classification improved, with the Random Forest model showing the most significant enhancement. The AUC value increased from 0.88 to 0.92. Conclusions: The Combat algorithm has reduced variability in radiomic features from different scanners. In the phantom CT dataset, it appears that the machine learning model’s classification performance may have improved after Combat harmonization. However, further investigation and validation are required to fully comprehend Combat’s impact on radiomic features in medical imaging. BioMed Central 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/113473/1/113473.pdf Zhang, Xiaolei and Iqbal bin Saripan, M. and Wu, Yanjun and Wang, Zhongxiao and Wen, Dong and Cao, Zhendong and Wang, Bingzhen and Xu, Shiqi and Liu, Yanli and Marhaban, Mohammad Hamiruce and Dong, Xianling (2024) The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers. BMC Medical Imaging, 24 (1). art. no. 137. pp. 1-12. ISSN 1471-2342; eISSN: 1471-2342 https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12880-024-01306-4 10.1186/s12880-024-01306-4
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Background: This study investigated whether the Combat compensation method can remove the variability of radiomic features extracted from different scanners, while also examining its impact on the subsequent predictive performance of machine learning models. Materials and methods: 135 CT images of Credence Cartridge Radiomic phantoms were collected and screened from three scanners manufactured by Siemens, Philips, and GE. 100 radiomic features were extracted and 20 radiomic features were screened according to the Lasso regression method. The radiomic features extracted from the rubber and resin-filled regions in the cartridges were labeled into different categories for evaluating the performance of the machine learning model. Radiomics features were divided into three groups based on the different scanner manufacturers. The radiomic features were randomly divided into training and test sets with a ratio of 8:2. Five machine learning models (lasso, logistic regression, random forest, support vector machine, neural network) were employed to evaluate the impact of Combat on radiomic features. The variability among radiomic features were assessed using analysis of variance (ANOVA) and principal component analysis (PCA). Accuracy, precision, recall, and area under the receiver curve (AUC) were used as evaluation metrics for model classification. Results: The principal component and ANOVA analysis results show that the variability of different scanner manufacturers in radiomic features was removed (P˃0.05). After harmonization with the Combat algorithm, the distributions of radiomic features were aligned in terms of location and scale. The performance of machine learning models for classification improved, with the Random Forest model showing the most significant enhancement. The AUC value increased from 0.88 to 0.92. Conclusions: The Combat algorithm has reduced variability in radiomic features from different scanners. In the phantom CT dataset, it appears that the machine learning model’s classification performance may have improved after Combat harmonization. However, further investigation and validation are required to fully comprehend Combat’s impact on radiomic features in medical imaging.
format	Article
author	Zhang, Xiaolei Iqbal bin Saripan, M. Wu, Yanjun Wang, Zhongxiao Wen, Dong Cao, Zhendong Wang, Bingzhen Xu, Shiqi Liu, Yanli Marhaban, Mohammad Hamiruce Dong, Xianling
spellingShingle	Zhang, Xiaolei Iqbal bin Saripan, M. Wu, Yanjun Wang, Zhongxiao Wen, Dong Cao, Zhendong Wang, Bingzhen Xu, Shiqi Liu, Yanli Marhaban, Mohammad Hamiruce Dong, Xianling The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
author_facet	Zhang, Xiaolei Iqbal bin Saripan, M. Wu, Yanjun Wang, Zhongxiao Wen, Dong Cao, Zhendong Wang, Bingzhen Xu, Shiqi Liu, Yanli Marhaban, Mohammad Hamiruce Dong, Xianling
author_sort	Zhang, Xiaolei
title	The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
title_short	The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
title_full	The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
title_fullStr	The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
title_full_unstemmed	The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
title_sort	impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
publisher	BioMed Central
publishDate	2024
url	http://psasir.upm.edu.my/id/eprint/113473/1/113473.pdf http://psasir.upm.edu.my/id/eprint/113473/ https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12880-024-01306-4
_version_	1817844641997783040
score	13.222552

The impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers

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