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Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties

The use of essential oils as natural antioxidant, antimicrobial and insect repellent agent was limited by the loss of bioactive components especially volatile compounds. This study aimed to improve biological properties of curry leaf essential oil (CLEO) by producing nanometer sized particles throug...

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Main Authors: R., Nur Fatin Nazurah, M.A., Noranizan, M.A.R., Nor-Khaizura, Z.A., Nur Hanani
Format: Article
Language:English
Published: Elsevier 2024
Online Access:http://psasir.upm.edu.my/id/eprint/113328/1/113328.pdf
http://psasir.upm.edu.my/id/eprint/113328/
https://www.sciencedirect.com/science/article/pii/S0141813024037772
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spelling my.upm.eprints.1133282024-11-19T08:23:03Z http://psasir.upm.edu.my/id/eprint/113328/ Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties R., Nur Fatin Nazurah M.A., Noranizan M.A.R., Nor-Khaizura Z.A., Nur Hanani The use of essential oils as natural antioxidant, antimicrobial and insect repellent agent was limited by the loss of bioactive components especially volatile compounds. This study aimed to improve biological properties of curry leaf essential oil (CLEO) by producing nanometer sized particles through two different synthesis techniques; nanoencapsulation and nanoprecipitation. The methods produced different nanostructures; nanocapsules and nanospheres distinguished by the morphological structure (TEM analysis). Successful loading of CLEO into chitosan nanocarrier was proven by FTIR spectra. Zeta potential values for both nanostructures were more than +30 mV implying their stability against aggregation. CLEO loaded nanocapsules exhibited highest antibacterial properties against Gram-positive bacteria compared to nanospheres. Meanwhile, CLEO loaded nanospheres recorded up until 90.44 % DPPH radical scavenging properties, higher compared to nanocapsules. Both nanostructures demonstrated further improvement in antioxidant and antibacterial activities with the incorporation of higher chitosan concentration. In vitro release analysis indicated that CLEO undergo two-stage discharge mechanism where fast discharge occurred up until 12 h followed by sustained released afterwards. The two synthesis methods applied synergistically with greater chitosan concentration successfully produced nanostructures with >60 % encapsulation efficiency (EE). This concluded that both techniques were reliable to protect the bioactive constituents of CLEO for further used. Elsevier 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/113328/1/113328.pdf R., Nur Fatin Nazurah and M.A., Noranizan and M.A.R., Nor-Khaizura and Z.A., Nur Hanani (2024) Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties. International Journal of Biological Macromolecules, 273. art. no. 132972. pp. 1-11. ISSN 0141-8130; eISSN: 1879-0003 https://www.sciencedirect.com/science/article/pii/S0141813024037772 10.1016/j.ijbiomac.2024.132972
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The use of essential oils as natural antioxidant, antimicrobial and insect repellent agent was limited by the loss of bioactive components especially volatile compounds. This study aimed to improve biological properties of curry leaf essential oil (CLEO) by producing nanometer sized particles through two different synthesis techniques; nanoencapsulation and nanoprecipitation. The methods produced different nanostructures; nanocapsules and nanospheres distinguished by the morphological structure (TEM analysis). Successful loading of CLEO into chitosan nanocarrier was proven by FTIR spectra. Zeta potential values for both nanostructures were more than +30 mV implying their stability against aggregation. CLEO loaded nanocapsules exhibited highest antibacterial properties against Gram-positive bacteria compared to nanospheres. Meanwhile, CLEO loaded nanospheres recorded up until 90.44 % DPPH radical scavenging properties, higher compared to nanocapsules. Both nanostructures demonstrated further improvement in antioxidant and antibacterial activities with the incorporation of higher chitosan concentration. In vitro release analysis indicated that CLEO undergo two-stage discharge mechanism where fast discharge occurred up until 12 h followed by sustained released afterwards. The two synthesis methods applied synergistically with greater chitosan concentration successfully produced nanostructures with >60 % encapsulation efficiency (EE). This concluded that both techniques were reliable to protect the bioactive constituents of CLEO for further used.
format Article
author R., Nur Fatin Nazurah
M.A., Noranizan
M.A.R., Nor-Khaizura
Z.A., Nur Hanani
spellingShingle R., Nur Fatin Nazurah
M.A., Noranizan
M.A.R., Nor-Khaizura
Z.A., Nur Hanani
Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties
author_facet R., Nur Fatin Nazurah
M.A., Noranizan
M.A.R., Nor-Khaizura
Z.A., Nur Hanani
author_sort R., Nur Fatin Nazurah
title Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties
title_short Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties
title_full Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties
title_fullStr Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties
title_full_unstemmed Chitosan nanoparticles incorporate with curry leaf essential oil: Physicochemical characterization and in vitro release properties
title_sort chitosan nanoparticles incorporate with curry leaf essential oil: physicochemical characterization and in vitro release properties
publisher Elsevier
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/113328/1/113328.pdf
http://psasir.upm.edu.my/id/eprint/113328/
https://www.sciencedirect.com/science/article/pii/S0141813024037772
_version_ 1817844625219518464
score 13.223943

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