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Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes

The ligand S-benzyldithiocarbazate (SBDTC) acts as a bidentate sulfur-nitrogen chelating agent. The reaction of SnII or SbIII with SBDTC under alkaline conditions gives complexes of composition [Sn(SBDTCA)2]·2H2O and [Sb(SBDTCA)Cl2·2H2O]. A quadridentate Schiff base of SBDTC with benzil, having a do...

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Main Authors: H. Tarafder, M. Tofazzal, Ali, A. Manaf, Elias, M. Suhaimi, Crouse, Karen A., Silong, Sidik
Format: Article
Published: Springer 2000
Online Access:http://psasir.upm.edu.my/id/eprint/113035/
https://link.springer.com/article/10.1023/A:1007069601569?error=cookies_not_supported&code=24251963-1672-4cbc-b9d7-a75323e5b6c3
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spelling my.upm.eprints.1130352025-01-10T09:01:44Z http://psasir.upm.edu.my/id/eprint/113035/ Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes H. Tarafder, M. Tofazzal Ali, A. Manaf Elias, M. Suhaimi Crouse, Karen A. Silong, Sidik The ligand S-benzyldithiocarbazate (SBDTC) acts as a bidentate sulfur-nitrogen chelating agent. The reaction of SnII or SbIII with SBDTC under alkaline conditions gives complexes of composition [Sn(SBDTCA)2]·2H2O and [Sb(SBDTCA)Cl2·2H2O]. A quadridentate Schiff base of SBDTC with benzil, having a donor sequence SNNS, yields complexes, [Cd(SNNS)] and [Zr(O)(SNNS)·H2O]. The ligands and the complexes have been characterized by elemental analyses, i.r., u.v.-vis., molar conductance measurements and 1H-n.m.r. spectroscopy. SBDTC, SnII and SbIII complexes and the SNNS Schiff base together with its CdII and ZrIV complexes display significant antifungal, antibacterial and anti-cancer activity. The SnII complex and the SNNS free Schiff base were very effective against Melanoma (skin cancer cells). The SBDTC and its SnII complex were also very effective against Renal carcinoma (kidney cancer cells). The results have been compared with those of the uncomplexed metal salts and the free ligands. The minimum concentrations for the evaluation of the above activities for CD50 of the samples were in the 1.0-15 μg cm-3 range. Springer 2000 Article PeerReviewed H. Tarafder, M. Tofazzal and Ali, A. Manaf and Elias, M. Suhaimi and Crouse, Karen A. and Silong, Sidik (2000) Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes. Transition Metal Chemistry, 25 (6). pp. 706-710. ISSN 0340-4285; eISSN: 1572-901X https://link.springer.com/article/10.1023/A:1007069601569?error=cookies_not_supported&code=24251963-1672-4cbc-b9d7-a75323e5b6c3 10.1023/a:1007069601569
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The ligand S-benzyldithiocarbazate (SBDTC) acts as a bidentate sulfur-nitrogen chelating agent. The reaction of SnII or SbIII with SBDTC under alkaline conditions gives complexes of composition [Sn(SBDTCA)2]·2H2O and [Sb(SBDTCA)Cl2·2H2O]. A quadridentate Schiff base of SBDTC with benzil, having a donor sequence SNNS, yields complexes, [Cd(SNNS)] and [Zr(O)(SNNS)·H2O]. The ligands and the complexes have been characterized by elemental analyses, i.r., u.v.-vis., molar conductance measurements and 1H-n.m.r. spectroscopy. SBDTC, SnII and SbIII complexes and the SNNS Schiff base together with its CdII and ZrIV complexes display significant antifungal, antibacterial and anti-cancer activity. The SnII complex and the SNNS free Schiff base were very effective against Melanoma (skin cancer cells). The SBDTC and its SnII complex were also very effective against Renal carcinoma (kidney cancer cells). The results have been compared with those of the uncomplexed metal salts and the free ligands. The minimum concentrations for the evaluation of the above activities for CD50 of the samples were in the 1.0-15 μg cm-3 range.
format Article
author H. Tarafder, M. Tofazzal
Ali, A. Manaf
Elias, M. Suhaimi
Crouse, Karen A.
Silong, Sidik
spellingShingle H. Tarafder, M. Tofazzal
Ali, A. Manaf
Elias, M. Suhaimi
Crouse, Karen A.
Silong, Sidik
Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
author_facet H. Tarafder, M. Tofazzal
Ali, A. Manaf
Elias, M. Suhaimi
Crouse, Karen A.
Silong, Sidik
author_sort H. Tarafder, M. Tofazzal
title Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
title_short Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
title_full Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
title_fullStr Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
title_full_unstemmed Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
title_sort coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes
publisher Springer
publishDate 2000
url http://psasir.upm.edu.my/id/eprint/113035/
https://link.springer.com/article/10.1023/A:1007069601569?error=cookies_not_supported&code=24251963-1672-4cbc-b9d7-a75323e5b6c3
_version_ 1821108000245415936
score 13.235796

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