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Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats

The pharmacokinetic behaviour of tylosin was compared in five Desert sheep and five Nubian goats. The animals were given a single dose of 20% tylosin (15 mg/kg), either intravenously (i.v.) or intramuscularly (i.m.). Following i.v. administration, the volumes of distribution and the elimination half...

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Main Authors: Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam
Format: Article
Language:English
Published: Elsevier 1999
Online Access:http://psasir.upm.edu.my/id/eprint/112737/1/112737.pdf
http://psasir.upm.edu.my/id/eprint/112737/
https://linkinghub.elsevier.com/retrieve/pii/S109002339990374X
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spelling my.upm.eprints.1127372025-01-27T07:04:12Z http://psasir.upm.edu.my/id/eprint/112737/ Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats Taha, A.A. Elsheikh, H.A. Khalafalla, A.E. Osman, I. A. M. Abdullah, A. Salam The pharmacokinetic behaviour of tylosin was compared in five Desert sheep and five Nubian goats. The animals were given a single dose of 20% tylosin (15 mg/kg), either intravenously (i.v.) or intramuscularly (i.m.). Following i.v. administration, the volumes of distribution and the elimination half-life times were similar in both species, whereas in goats a greater volume of the central compartment and faster clearance were observed. For the i.m. route, similar pharmacokinetics were observed in both species. The bioavailability (f) of the drug in goats (0.84 ± 0.11) was not significantly higher than that in sheep (0.73 ± 0.08). The present study has shown that, despite the significant differences in some of the drug pharmacokinetic parameters between sheep and goats for the i.v. route, identical intravenous and intramuscular dosage regimens of tylosin may be recommended for the two species. Elsevier 1999 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/112737/1/112737.pdf Taha, A.A. and Elsheikh, H.A. and Khalafalla, A.E. and Osman, I. A. M. and Abdullah, A. Salam (1999) Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats. The Veterinary Journal, 158 (3). pp. 210-215. ISSN 1090-0233; eISSN: 1532-2971 https://linkinghub.elsevier.com/retrieve/pii/S109002339990374X 10.1053/tvjl.1999.0374
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The pharmacokinetic behaviour of tylosin was compared in five Desert sheep and five Nubian goats. The animals were given a single dose of 20% tylosin (15 mg/kg), either intravenously (i.v.) or intramuscularly (i.m.). Following i.v. administration, the volumes of distribution and the elimination half-life times were similar in both species, whereas in goats a greater volume of the central compartment and faster clearance were observed. For the i.m. route, similar pharmacokinetics were observed in both species. The bioavailability (f) of the drug in goats (0.84 ± 0.11) was not significantly higher than that in sheep (0.73 ± 0.08). The present study has shown that, despite the significant differences in some of the drug pharmacokinetic parameters between sheep and goats for the i.v. route, identical intravenous and intramuscular dosage regimens of tylosin may be recommended for the two species.
format Article
author Taha, A.A.
Elsheikh, H.A.
Khalafalla, A.E.
Osman, I. A. M.
Abdullah, A. Salam
spellingShingle Taha, A.A.
Elsheikh, H.A.
Khalafalla, A.E.
Osman, I. A. M.
Abdullah, A. Salam
Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
author_facet Taha, A.A.
Elsheikh, H.A.
Khalafalla, A.E.
Osman, I. A. M.
Abdullah, A. Salam
author_sort Taha, A.A.
title Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
title_short Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
title_full Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
title_fullStr Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
title_full_unstemmed Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats
title_sort disposition kinetics of tylosin administered intravenously and intramuscularly in desert sheep and nubian goats
publisher Elsevier
publishDate 1999
url http://psasir.upm.edu.my/id/eprint/112737/1/112737.pdf
http://psasir.upm.edu.my/id/eprint/112737/
https://linkinghub.elsevier.com/retrieve/pii/S109002339990374X
_version_ 1823093025566359552
score 13.244413

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