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Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo

Zingiberaceae are known as valuable herbs with an important role in the prevention and treatment of various diseases. More than 300 species of Zingiberaceae were documented in Borneo. In this study, methanolic extracts of three species of Zingiberaceae (namely, Etlingera velutina, Etlingera belalong...

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Main Authors: Sabli, Farrawati, Mohamed, Maryati, Rahmat, Asmah, Abu Bakar, Mohd Fadzelly
Format: Article
Language:English
Published: Universiti Putra Malaysia Press 2012
Online Access:http://psasir.upm.edu.my/id/eprint/11229/1/64.%20Cytotoxic%20properties%20of%20selected%20etlingera%20spp.%20and%20zingiber%20spp.%20%28Zingiberaceae%29%20endemic%20to%20Borneo.pdf
http://psasir.upm.edu.my/id/eprint/11229/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2035%20(3)%20Aug.%202012/21%20pg%20663-671.pdf
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spelling my.upm.eprints.112292015-11-23T07:01:20Z http://psasir.upm.edu.my/id/eprint/11229/ Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo Sabli, Farrawati Mohamed, Maryati Rahmat, Asmah Abu Bakar, Mohd Fadzelly Zingiberaceae are known as valuable herbs with an important role in the prevention and treatment of various diseases. More than 300 species of Zingiberaceae were documented in Borneo. In this study, methanolic extracts of three species of Zingiberaceae (namely, Etlingera velutina, Etlingera belalongensis and Zingiber vinosum) were analysed for their total phenolic and flavonoid contents and cytotoxic activity in vitro. The cytotoxic activities of these extracts were tested against several cancer cell lines, such as hormone dependent breast cancer (MCF-7), non-hormone dependent cancer (MDA-MB-231), ovarian cancer (CaOV3) and cervical cancer (Hela) using MTT assay. Crude extracts from rhizome of E. belalongensis and E. velutina showed significant cytotoxic activity against MDA-MB-231 cell line proliferation, with IC50 values (concentration which inhibit 50% of cell population) of 51.00±4.24 µg/ml and 67.00±9.89 µg/ml, respectively. The methanol extracts were further analysed for the cell cycle analysis using flow cytometry. The results showed that the Etlingera species exhibited higher antioxidant activity and stronger cytotoxic activity in selected cancer cell lines, with the highest cell death accumulated in G1 phase as compared to Zingiber species. Thus, polyphenol phytochemicals could be the major contributors to the cytotoxic activity of these species. As a conclusion, tropical gingers in Borneo investigated in this study have the potential to be developed as anticancer remedies. Universiti Putra Malaysia Press 2012 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/11229/1/64.%20Cytotoxic%20properties%20of%20selected%20etlingera%20spp.%20and%20zingiber%20spp.%20%28Zingiberaceae%29%20endemic%20to%20Borneo.pdf Sabli, Farrawati and Mohamed, Maryati and Rahmat, Asmah and Abu Bakar, Mohd Fadzelly (2012) Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo. Pertanika Journal of Tropical Agricultural Science, 35 (3). pp. 663-671. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2035%20(3)%20Aug.%202012/21%20pg%20663-671.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Zingiberaceae are known as valuable herbs with an important role in the prevention and treatment of various diseases. More than 300 species of Zingiberaceae were documented in Borneo. In this study, methanolic extracts of three species of Zingiberaceae (namely, Etlingera velutina, Etlingera belalongensis and Zingiber vinosum) were analysed for their total phenolic and flavonoid contents and cytotoxic activity in vitro. The cytotoxic activities of these extracts were tested against several cancer cell lines, such as hormone dependent breast cancer (MCF-7), non-hormone dependent cancer (MDA-MB-231), ovarian cancer (CaOV3) and cervical cancer (Hela) using MTT assay. Crude extracts from rhizome of E. belalongensis and E. velutina showed significant cytotoxic activity against MDA-MB-231 cell line proliferation, with IC50 values (concentration which inhibit 50% of cell population) of 51.00±4.24 µg/ml and 67.00±9.89 µg/ml, respectively. The methanol extracts were further analysed for the cell cycle analysis using flow cytometry. The results showed that the Etlingera species exhibited higher antioxidant activity and stronger cytotoxic activity in selected cancer cell lines, with the highest cell death accumulated in G1 phase as compared to Zingiber species. Thus, polyphenol phytochemicals could be the major contributors to the cytotoxic activity of these species. As a conclusion, tropical gingers in Borneo investigated in this study have the potential to be developed as anticancer remedies.
format Article
author Sabli, Farrawati
Mohamed, Maryati
Rahmat, Asmah
Abu Bakar, Mohd Fadzelly
spellingShingle Sabli, Farrawati
Mohamed, Maryati
Rahmat, Asmah
Abu Bakar, Mohd Fadzelly
Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo
author_facet Sabli, Farrawati
Mohamed, Maryati
Rahmat, Asmah
Abu Bakar, Mohd Fadzelly
author_sort Sabli, Farrawati
title Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo
title_short Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo
title_full Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo
title_fullStr Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo
title_full_unstemmed Cytotoxic properties of selected Etlingera spp. and Zingiber spp. (Zingiberaceae) endemic to Borneo
title_sort cytotoxic properties of selected etlingera spp. and zingiber spp. (zingiberaceae) endemic to borneo
publisher Universiti Putra Malaysia Press
publishDate 2012
url http://psasir.upm.edu.my/id/eprint/11229/1/64.%20Cytotoxic%20properties%20of%20selected%20etlingera%20spp.%20and%20zingiber%20spp.%20%28Zingiberaceae%29%20endemic%20to%20Borneo.pdf
http://psasir.upm.edu.my/id/eprint/11229/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2035%20(3)%20Aug.%202012/21%20pg%20663-671.pdf
_version_ 1643824777802022912
score 13.211869

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