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Cytotoxicity and electron microscopy of cell death induced by goniothalamin

The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ul...

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Main Authors: Ali, A., McKeen, M., Hamid, M., Aun, Q., Zauyah, Y., Azimahtol, H., Kawazu, K.
Format: Article
Published: Georg Thieme Verlag KG 1997
Online Access:http://psasir.upm.edu.my/id/eprint/111947/
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2006-957611
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spelling my.upm.eprints.1119472025-03-03T01:33:04Z http://psasir.upm.edu.my/id/eprint/111947/ Cytotoxicity and electron microscopy of cell death induced by goniothalamin Ali, A. McKeen, M. Hamid, M. Aun, Q. Zauyah, Y. Azimahtol, H. Kawazu, K. The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells. Georg Thieme Verlag KG 1997 Article PeerReviewed Ali, A. and McKeen, M. and Hamid, M. and Aun, Q. and Zauyah, Y. and Azimahtol, H. and Kawazu, K. (1997) Cytotoxicity and electron microscopy of cell death induced by goniothalamin. Planta Medica, 63 (1). pp. 81-83. ISSN 0032-0943; eISSN: 1439-0221 https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2006-957611 10.1055/s-2006-957611
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
format Article
author Ali, A.
McKeen, M.
Hamid, M.
Aun, Q.
Zauyah, Y.
Azimahtol, H.
Kawazu, K.
spellingShingle Ali, A.
McKeen, M.
Hamid, M.
Aun, Q.
Zauyah, Y.
Azimahtol, H.
Kawazu, K.
Cytotoxicity and electron microscopy of cell death induced by goniothalamin
author_facet Ali, A.
McKeen, M.
Hamid, M.
Aun, Q.
Zauyah, Y.
Azimahtol, H.
Kawazu, K.
author_sort Ali, A.
title Cytotoxicity and electron microscopy of cell death induced by goniothalamin
title_short Cytotoxicity and electron microscopy of cell death induced by goniothalamin
title_full Cytotoxicity and electron microscopy of cell death induced by goniothalamin
title_fullStr Cytotoxicity and electron microscopy of cell death induced by goniothalamin
title_full_unstemmed Cytotoxicity and electron microscopy of cell death induced by goniothalamin
title_sort cytotoxicity and electron microscopy of cell death induced by goniothalamin
publisher Georg Thieme Verlag KG
publishDate 1997
url http://psasir.upm.edu.my/id/eprint/111947/
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2006-957611
_version_ 1825810707933822976
score 13.244413

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