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In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract

Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthu...

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Main Authors: Zulkifli, Siti Atikah, Abd Gani, Siti Salwa, Zaidan, Uswatun Hasanah, Misran, Azizah, Hassan, Masriana
Format: Article
Language:English
Published: Taylor and Francis Ltd. 2024
Online Access:http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf
http://psasir.upm.edu.my/id/eprint/111540/
https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2344190
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spelling my.upm.eprints.1115402024-08-04T08:53:01Z http://psasir.upm.edu.my/id/eprint/111540/ In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract Zulkifli, Siti Atikah Abd Gani, Siti Salwa Zaidan, Uswatun Hasanah Misran, Azizah Hassan, Masriana Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthus seed extract (DSMSE). Anti-inflammatory properties of DSMSE on LPS-induced inflammation on THP-1 were determined by measuring the levels of interleukins IL-6, IL-8, and IL-10. Wound healing scratch assay was performed using the human fibroblast (Hs27) cell that assesses the cell migration over 24 h exposure to DSMSE. Administration of DSMSE significantly reduced the LPS-stimulated release levels of IL-6 and IL-8 and significantly increased the levels of IL-10. Treatment with DSMSE showed a significant increase in wound closure with 70% of fibroblast migration. Therefore, the current study showed the anti-inflammatory and wound healing properties of DSMSE reducing inflammatory cytokines (IL-6 and IL-8), increasing IL-10 cytokine, and increasing wound closure at 24 h. Taylor and Francis Ltd. 2024-05-14 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf Zulkifli, Siti Atikah and Abd Gani, Siti Salwa and Zaidan, Uswatun Hasanah and Misran, Azizah and Hassan, Masriana (2024) In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract. Natural Product Research. pp. 1-9. ISSN 1478-6419; EISSN: 1478-6427 (In Press) https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2344190 10.1080/14786419.2024.2344190
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Extracts from Selenicereus monacanthus (synonym: Hylocereus polyrhizus) have received attention due to their potent anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. The current study aims to determine the anti-inflammatory and wound-healing potential of defatted S. monacanthus seed extract (DSMSE). Anti-inflammatory properties of DSMSE on LPS-induced inflammation on THP-1 were determined by measuring the levels of interleukins IL-6, IL-8, and IL-10. Wound healing scratch assay was performed using the human fibroblast (Hs27) cell that assesses the cell migration over 24 h exposure to DSMSE. Administration of DSMSE significantly reduced the LPS-stimulated release levels of IL-6 and IL-8 and significantly increased the levels of IL-10. Treatment with DSMSE showed a significant increase in wound closure with 70% of fibroblast migration. Therefore, the current study showed the anti-inflammatory and wound healing properties of DSMSE reducing inflammatory cytokines (IL-6 and IL-8), increasing IL-10 cytokine, and increasing wound closure at 24 h.
format Article
author Zulkifli, Siti Atikah
Abd Gani, Siti Salwa
Zaidan, Uswatun Hasanah
Misran, Azizah
Hassan, Masriana
spellingShingle Zulkifli, Siti Atikah
Abd Gani, Siti Salwa
Zaidan, Uswatun Hasanah
Misran, Azizah
Hassan, Masriana
In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
author_facet Zulkifli, Siti Atikah
Abd Gani, Siti Salwa
Zaidan, Uswatun Hasanah
Misran, Azizah
Hassan, Masriana
author_sort Zulkifli, Siti Atikah
title In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
title_short In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
title_full In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
title_fullStr In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
title_full_unstemmed In vitro anti-inflammatory and wound healing properties of defatted Selenicereus monacanthus (Lem.) D.R.Hunt seed extract
title_sort in vitro anti-inflammatory and wound healing properties of defatted selenicereus monacanthus (lem.) d.r.hunt seed extract
publisher Taylor and Francis Ltd.
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/111540/1/In%20vitro%20anti-inflammatory%20and%20wound%20healing%20properties%20of%20defatted%20Selenicereus%20monacanthus%20%20Lem.%20%20D.R.Hunt%20seed%20extract%20%281%29.pdf
http://psasir.upm.edu.my/id/eprint/111540/
https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2344190
_version_ 1806512715963826176
score 13.211869

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