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Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study

Background & Aims: Accumulating evidence showed that inflammation contributes markedly to cancer progression, with C-reactive protein (CRP) being one of the lengthily studied inflammation marker. For breast cancer (BCa), pre-treatment elevated CRP upon diagnosis was linked with increased mortal...

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Main Authors: Abu Zaid, Zalina, Ng, Wai Han, Mohd Yusof, Barakatun Nisak, Amin Nordin, Syafinaz, Lim, Poh Ying
Format: Article
Language:English
Published: Elsevier Ltd 2024
Online Access:http://psasir.upm.edu.my/id/eprint/111456/1/PUBLISHED.pdf
http://psasir.upm.edu.my/id/eprint/111456/
https://www.sciencedirect.com/science/article/pii/S246829422400025X
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spelling my.upm.eprints.1114562024-07-14T08:28:42Z http://psasir.upm.edu.my/id/eprint/111456/ Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study Abu Zaid, Zalina Ng, Wai Han Mohd Yusof, Barakatun Nisak Amin Nordin, Syafinaz Lim, Poh Ying Background & Aims: Accumulating evidence showed that inflammation contributes markedly to cancer progression, with C-reactive protein (CRP) being one of the lengthily studied inflammation marker. For breast cancer (BCa), pre-treatment elevated CRP upon diagnosis was linked with increased mortality. This study aimed to identify factors predictive of elevated CRP in pre-treatment BCa population that can serve as potential therapeutic targets to reduce inflammation.Methods: This is a cross-sectional study using multiple logistic regression to identify predictors of elevated CRP among pre-treatment, newly diagnosed BCa patients. Studied variables were socio-demographic and medical characteristics, anthropometric measurements [body weight, Body Mass Index, body fat percentage, fat mass/fat free mass ratio, muscle mass, visceral fat], biochemical parameters [albumin, hemoglobin, white blood cell (WBC), neutrophil, lymphocyte], energy-adjusted Dietary Inflammatory Index, handgrip strength (HGS), scored Patient Generated-Subjective Global Assessment, physical activity level and perceived stress scale (PSS). Results: A total of 105 participants took part in this study. Significant predictors of elevated CRP were body fat percentage (OR 1.222; 95 % CI 1.099–1.358; p < 0.001), PSS (OR 1.120; 95 % CI 1.026–1.223; p = 0.011), low vs normal HGS (OR 41.928; 95 % CI 2.155–815.728; p = 0.014), albumin (OR 0.779; 95 % CI 0.632–0.960; p = 0.019), and WBC (OR 1.418; 95% CI 1.024–1.963; p = 0.036). Conclusion: Overall, predictors of elevated CRP in pre-treatment, newly diagnosed BCa population were body fat percentage, PSS, HGS category, albumin and WBC. Elsevier Ltd 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111456/1/PUBLISHED.pdf Abu Zaid, Zalina and Ng, Wai Han and Mohd Yusof, Barakatun Nisak and Amin Nordin, Syafinaz and Lim, Poh Ying (2024) Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study. Cancer Treatment and Research Communications, 39. art. no. 100813. pp. 1-7. ISSN 2468-2942 https://www.sciencedirect.com/science/article/pii/S246829422400025X 10.1016/j.ctarc.2024.100813
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background & Aims: Accumulating evidence showed that inflammation contributes markedly to cancer progression, with C-reactive protein (CRP) being one of the lengthily studied inflammation marker. For breast cancer (BCa), pre-treatment elevated CRP upon diagnosis was linked with increased mortality. This study aimed to identify factors predictive of elevated CRP in pre-treatment BCa population that can serve as potential therapeutic targets to reduce inflammation.Methods: This is a cross-sectional study using multiple logistic regression to identify predictors of elevated CRP among pre-treatment, newly diagnosed BCa patients. Studied variables were socio-demographic and medical characteristics, anthropometric measurements [body weight, Body Mass Index, body fat percentage, fat mass/fat free mass ratio, muscle mass, visceral fat], biochemical parameters [albumin, hemoglobin, white blood cell (WBC), neutrophil, lymphocyte], energy-adjusted Dietary Inflammatory Index, handgrip strength (HGS), scored Patient Generated-Subjective Global Assessment, physical activity level and perceived stress scale (PSS). Results: A total of 105 participants took part in this study. Significant predictors of elevated CRP were body fat percentage (OR 1.222; 95 % CI 1.099–1.358; p < 0.001), PSS (OR 1.120; 95 % CI 1.026–1.223; p = 0.011), low vs normal HGS (OR 41.928; 95 % CI 2.155–815.728; p = 0.014), albumin (OR 0.779; 95 % CI 0.632–0.960; p = 0.019), and WBC (OR 1.418; 95% CI 1.024–1.963; p = 0.036). Conclusion: Overall, predictors of elevated CRP in pre-treatment, newly diagnosed BCa population were body fat percentage, PSS, HGS category, albumin and WBC.
format Article
author Abu Zaid, Zalina
Ng, Wai Han
Mohd Yusof, Barakatun Nisak
Amin Nordin, Syafinaz
Lim, Poh Ying
spellingShingle Abu Zaid, Zalina
Ng, Wai Han
Mohd Yusof, Barakatun Nisak
Amin Nordin, Syafinaz
Lim, Poh Ying
Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
author_facet Abu Zaid, Zalina
Ng, Wai Han
Mohd Yusof, Barakatun Nisak
Amin Nordin, Syafinaz
Lim, Poh Ying
author_sort Abu Zaid, Zalina
title Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
title_short Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
title_full Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
title_fullStr Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
title_full_unstemmed Predictors of elevated C-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
title_sort predictors of elevated c-reactive protein among pre-treatment, newly diagnosed breast cancer patients: a cross-sectional study
publisher Elsevier Ltd
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/111456/1/PUBLISHED.pdf
http://psasir.upm.edu.my/id/eprint/111456/
https://www.sciencedirect.com/science/article/pii/S246829422400025X
_version_ 1805889535667601408
score 13.211869

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