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Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia

A high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency. Factors including low dietary vitamin D intake and single nucleotide polymorphisms in the vitamin D metabolism genes have been ass...

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Main Authors: Lee, Siew-Siew, Ling, King-Hwa, Subramaniam, Raman, Tusimin, Maiza, Rahim, Kartini Farah, Loh, Su-Peng
Format: Article
Language:English
Published: Elsevier BV 2024
Online Access:http://psasir.upm.edu.my/id/eprint/111175/1/Genetic%20variants%20and%20non-genetic%20factors%20associated%20with%20a%20high%20prevalence%20of%20vitamin%20D%20deficiency%20in%20full-term%20neonates%20in%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/111175/
https://linkinghub.elsevier.com/retrieve/pii/S2666149724000215
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spelling my.upm.eprints.1111752024-06-22T15:09:02Z http://psasir.upm.edu.my/id/eprint/111175/ Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia Lee, Siew-Siew Ling, King-Hwa Subramaniam, Raman Tusimin, Maiza Rahim, Kartini Farah Loh, Su-Peng A high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency. Factors including low dietary vitamin D intake and single nucleotide polymorphisms in the vitamin D metabolism genes have been associated with this deficiency in the population. However, there was limited data available regarding the prevalence of neonatal vitamin D deficiency and the factors associated with it among neonates in Malaysia. Therefore, this study aimed to determine the prevalence of vitamin D deficiency and explore the associations between maternal and neonatal gene polymorphisms, as well as non-genetic factors and neonatal vitamin D deficiency. A total of 217 mother-neonate dyads were recruited for this study. Data on skin type, maternal sun exposure, dietary intake, as well as maternal and neonatal 25-hydroxyvitamin D (25OHD) concentrations were collected. Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) and Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using high-resolution melting (HRM) and restriction fragment length polymorphism, respectively. The results showed that 60.4%, 71.4% and 95.4% of neonates had cord blood 25OHD levels below 25 nmol/L, 30 nmol/L and 50 nmol/L, respectively. After adjusting for the maternal vitamin D status, the maternal VDR rs2228570 GG genotype was significantly associated with neonatal vitamin D deficiency (25OHD<30 nmol/L) (aOR = 2.63, 95% CI: 1.18–5.87, p = 0.018). Maternal vitamin D supplement intake was found to be a protective factor. However, maternal and neonatal vitamin D binding protein (VDBP) SNPs were not associated with neonatal vitamin D deficiency. The high prevalence of neonatal vitamin D deficiency reported in this study indicates the urgent need for the development and implementation of strategies to improve neonatal vitamin D status. The findings suggest that maternal supplementation may be an effective approach to enhance the vitamin D status of neonates. Elsevier BV 2024-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/111175/1/Genetic%20variants%20and%20non-genetic%20factors%20associated%20with%20a%20high%20prevalence%20of%20vitamin%20D%20deficiency%20in%20full-term%20neonates%20in%20Malaysia.pdf Lee, Siew-Siew and Ling, King-Hwa and Subramaniam, Raman and Tusimin, Maiza and Rahim, Kartini Farah and Loh, Su-Peng (2024) Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia. Human Nutrition & Metabolism, 36. art. no. 200259. pp. 1-6. ISSN 2666-1497 https://linkinghub.elsevier.com/retrieve/pii/S2666149724000215 10.1016/j.hnm.2024.200259
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency. Factors including low dietary vitamin D intake and single nucleotide polymorphisms in the vitamin D metabolism genes have been associated with this deficiency in the population. However, there was limited data available regarding the prevalence of neonatal vitamin D deficiency and the factors associated with it among neonates in Malaysia. Therefore, this study aimed to determine the prevalence of vitamin D deficiency and explore the associations between maternal and neonatal gene polymorphisms, as well as non-genetic factors and neonatal vitamin D deficiency. A total of 217 mother-neonate dyads were recruited for this study. Data on skin type, maternal sun exposure, dietary intake, as well as maternal and neonatal 25-hydroxyvitamin D (25OHD) concentrations were collected. Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) and Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using high-resolution melting (HRM) and restriction fragment length polymorphism, respectively. The results showed that 60.4%, 71.4% and 95.4% of neonates had cord blood 25OHD levels below 25 nmol/L, 30 nmol/L and 50 nmol/L, respectively. After adjusting for the maternal vitamin D status, the maternal VDR rs2228570 GG genotype was significantly associated with neonatal vitamin D deficiency (25OHD<30 nmol/L) (aOR = 2.63, 95% CI: 1.18–5.87, p = 0.018). Maternal vitamin D supplement intake was found to be a protective factor. However, maternal and neonatal vitamin D binding protein (VDBP) SNPs were not associated with neonatal vitamin D deficiency. The high prevalence of neonatal vitamin D deficiency reported in this study indicates the urgent need for the development and implementation of strategies to improve neonatal vitamin D status. The findings suggest that maternal supplementation may be an effective approach to enhance the vitamin D status of neonates.
format Article
author Lee, Siew-Siew
Ling, King-Hwa
Subramaniam, Raman
Tusimin, Maiza
Rahim, Kartini Farah
Loh, Su-Peng
spellingShingle Lee, Siew-Siew
Ling, King-Hwa
Subramaniam, Raman
Tusimin, Maiza
Rahim, Kartini Farah
Loh, Su-Peng
Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
author_facet Lee, Siew-Siew
Ling, King-Hwa
Subramaniam, Raman
Tusimin, Maiza
Rahim, Kartini Farah
Loh, Su-Peng
author_sort Lee, Siew-Siew
title Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
title_short Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
title_full Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
title_fullStr Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
title_full_unstemmed Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
title_sort genetic variants and non-genetic factors associated with a high prevalence of vitamin d deficiency in full-term neonates in malaysia
publisher Elsevier BV
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/111175/1/Genetic%20variants%20and%20non-genetic%20factors%20associated%20with%20a%20high%20prevalence%20of%20vitamin%20D%20deficiency%20in%20full-term%20neonates%20in%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/111175/
https://linkinghub.elsevier.com/retrieve/pii/S2666149724000215
_version_ 1802978838311862272
score 13.211869

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