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Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia

Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen specie...

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Main Authors: Low, Zhao Xuan, Tan, Kai Li, Keong, Yong Yoke, Looi, Chung Yeng, Ooi, Yin Yin
Format: Article
Language:English
Published: Universiti Putra Malaysia 2023
Online Access:http://psasir.upm.edu.my/id/eprint/108360/1/108360.pdf
http://psasir.upm.edu.my/id/eprint/108360/
https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_3_may_2023-72844
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spelling my.upm.eprints.1083602024-10-24T07:26:09Z http://psasir.upm.edu.my/id/eprint/108360/ Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia Low, Zhao Xuan Tan, Kai Li Keong, Yong Yoke Looi, Chung Yeng Ooi, Yin Yin Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1 were used in the current study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 of TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06 and 49.16±0.63, respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH on microglial activation. Universiti Putra Malaysia 2023-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/108360/1/108360.pdf Low, Zhao Xuan and Tan, Kai Li and Keong, Yong Yoke and Looi, Chung Yeng and Ooi, Yin Yin (2023) Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia. Malaysian Journal of Medicine and Health Sciences, 19 (3). pp. 375-379. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_3_may_2023-72844 10.47836/mjmhs.19.3.47
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1 were used in the current study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 of TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06 and 49.16±0.63, respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH on microglial activation.
format Article
author Low, Zhao Xuan
Tan, Kai Li
Keong, Yong Yoke
Looi, Chung Yeng
Ooi, Yin Yin
spellingShingle Low, Zhao Xuan
Tan, Kai Li
Keong, Yong Yoke
Looi, Chung Yeng
Ooi, Yin Yin
Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
author_facet Low, Zhao Xuan
Tan, Kai Li
Keong, Yong Yoke
Looi, Chung Yeng
Ooi, Yin Yin
author_sort Low, Zhao Xuan
title Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
title_short Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
title_full Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
title_fullStr Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
title_full_unstemmed Tualang and Kelulut honey reduced Lipopolysaccharides-stimulated inflammatory responses of Microglia
title_sort tualang and kelulut honey reduced lipopolysaccharides-stimulated inflammatory responses of microglia
publisher Universiti Putra Malaysia
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/108360/1/108360.pdf
http://psasir.upm.edu.my/id/eprint/108360/
https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_3_may_2023-72844
_version_ 1814054655458541568
score 13.211869

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