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Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics

This case-control study, conducted at the Hospital USM BestARi unit, aimed to identify the serum metabolic fingerprint among individuals with breast lumps and healthy controls, and to discover potential biomarkers. Serum samples from healthy controls, benign breast lump patients, and malignant breas...

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Main Authors: Zulkefly, Ahmad, Abas, Faridah, Wan Azman, Wan Norlina, Omar, Julia, Ab Mutalib, Nurul Syakima, Syamsumir, Desy Fitrya
Format: Article
Published: HH Publisher 2023
Online Access:http://psasir.upm.edu.my/id/eprint/108248/
https://journals.hh-publisher.com/index.php/pmmb/article/view/922
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spelling my.upm.eprints.1082482024-09-11T03:20:22Z http://psasir.upm.edu.my/id/eprint/108248/ Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics Zulkefly, Ahmad Abas, Faridah Wan Azman, Wan Norlina Omar, Julia Ab Mutalib, Nurul Syakima Syamsumir, Desy Fitrya This case-control study, conducted at the Hospital USM BestARi unit, aimed to identify the serum metabolic fingerprint among individuals with breast lumps and healthy controls, and to discover potential biomarkers. Serum samples from healthy controls, benign breast lump patients, and malignant breast lump patients were analyzed using proton nuclear magnetic resonance spectroscopy (1H NMR). A multivariate data analysis approach was employed, with the OPLS-DA and clustered heat map techniques effectively differentiating between the three groups. The study revealed significant metabolite variations across the groups and proposed D-glucose, glycerol, and glycine as potential biomarkers for breast cancer diagnosis. Metabolic pathways such as alanine, aspartate, glutamate metabolism, and glycine, serine, and threonine metabolism were implicated. The metabolomics approach coupled with multivariate analysis successfully identified key metabolites leading to group separation and suggested altered metabolic pathways. However, further research and integration with other ‘omics’ technologies are necessary for clinical translation. HH Publisher 2023 Article PeerReviewed Zulkefly, Ahmad and Abas, Faridah and Wan Azman, Wan Norlina and Omar, Julia and Ab Mutalib, Nurul Syakima and Syamsumir, Desy Fitrya (2023) Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics. Progress in Microbes and Molecular Biology, 6 (1). art. no. a0000392. pp. 1-18. ISSN 2637-1049 https://journals.hh-publisher.com/index.php/pmmb/article/view/922 10.36877/pmmb.a0000392
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description This case-control study, conducted at the Hospital USM BestARi unit, aimed to identify the serum metabolic fingerprint among individuals with breast lumps and healthy controls, and to discover potential biomarkers. Serum samples from healthy controls, benign breast lump patients, and malignant breast lump patients were analyzed using proton nuclear magnetic resonance spectroscopy (1H NMR). A multivariate data analysis approach was employed, with the OPLS-DA and clustered heat map techniques effectively differentiating between the three groups. The study revealed significant metabolite variations across the groups and proposed D-glucose, glycerol, and glycine as potential biomarkers for breast cancer diagnosis. Metabolic pathways such as alanine, aspartate, glutamate metabolism, and glycine, serine, and threonine metabolism were implicated. The metabolomics approach coupled with multivariate analysis successfully identified key metabolites leading to group separation and suggested altered metabolic pathways. However, further research and integration with other ‘omics’ technologies are necessary for clinical translation.
format Article
author Zulkefly, Ahmad
Abas, Faridah
Wan Azman, Wan Norlina
Omar, Julia
Ab Mutalib, Nurul Syakima
Syamsumir, Desy Fitrya
spellingShingle Zulkefly, Ahmad
Abas, Faridah
Wan Azman, Wan Norlina
Omar, Julia
Ab Mutalib, Nurul Syakima
Syamsumir, Desy Fitrya
Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics
author_facet Zulkefly, Ahmad
Abas, Faridah
Wan Azman, Wan Norlina
Omar, Julia
Ab Mutalib, Nurul Syakima
Syamsumir, Desy Fitrya
author_sort Zulkefly, Ahmad
title Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics
title_short Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics
title_full Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics
title_fullStr Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics
title_full_unstemmed Identification of potential biomarkers and metabolic changes in the serum of breast lump patients among Kelantanese based on 1H NMR metabolomics
title_sort identification of potential biomarkers and metabolic changes in the serum of breast lump patients among kelantanese based on 1h nmr metabolomics
publisher HH Publisher
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/108248/
https://journals.hh-publisher.com/index.php/pmmb/article/view/922
_version_ 1811686013053960192
score 13.211869

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