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HIF-1 activation and inflammatory responses to hypoxiahypoxia

Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling...

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Main Authors: Shaharuddin, Shazreen, Nik Abd Rahman, Nik Mohd Afizan, Masarudin, Mas Jaffri, Alamassi, Mohammedarfat N
Format: Article
Published: Embry-Riddle Aeronautical University 2023
Online Access:http://psasir.upm.edu.my/id/eprint/108172/
https://commons.erau.edu/ijaaa/vol10/iss2/3/
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spelling my.upm.eprints.1081722024-09-23T01:57:58Z http://psasir.upm.edu.my/id/eprint/108172/ HIF-1 activation and inflammatory responses to hypoxiahypoxia Shaharuddin, Shazreen Nik Abd Rahman, Nik Mohd Afizan Masarudin, Mas Jaffri Alamassi, Mohammedarfat N Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, or the inability of tissues to utilise oxygen. Different organs are hypoxic due to differences in tissue oxygen tensions, which are determined by differences in aerobic metabolism. Extremely hypoxic individuals have the most dramatic systemic and neurological adaptations to persistent hypoxia. In this review, we provide an overview of central and systemic responses to hypoxia and discuss the activation of HIF-1 pathway. Embry-Riddle Aeronautical University 2023 Article PeerReviewed Shaharuddin, Shazreen and Nik Abd Rahman, Nik Mohd Afizan and Masarudin, Mas Jaffri and Alamassi, Mohammedarfat N (2023) HIF-1 activation and inflammatory responses to hypoxiahypoxia. International Journal of Aviation, Aeronautics, and Aerospace, 10 (2). art. no. 3. pp. 1-12. ISSN 2374-6793 https://commons.erau.edu/ijaaa/vol10/iss2/3/ 10.58940/2374-6793.1798
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, or the inability of tissues to utilise oxygen. Different organs are hypoxic due to differences in tissue oxygen tensions, which are determined by differences in aerobic metabolism. Extremely hypoxic individuals have the most dramatic systemic and neurological adaptations to persistent hypoxia. In this review, we provide an overview of central and systemic responses to hypoxia and discuss the activation of HIF-1 pathway.
format Article
author Shaharuddin, Shazreen
Nik Abd Rahman, Nik Mohd Afizan
Masarudin, Mas Jaffri
Alamassi, Mohammedarfat N
spellingShingle Shaharuddin, Shazreen
Nik Abd Rahman, Nik Mohd Afizan
Masarudin, Mas Jaffri
Alamassi, Mohammedarfat N
HIF-1 activation and inflammatory responses to hypoxiahypoxia
author_facet Shaharuddin, Shazreen
Nik Abd Rahman, Nik Mohd Afizan
Masarudin, Mas Jaffri
Alamassi, Mohammedarfat N
author_sort Shaharuddin, Shazreen
title HIF-1 activation and inflammatory responses to hypoxiahypoxia
title_short HIF-1 activation and inflammatory responses to hypoxiahypoxia
title_full HIF-1 activation and inflammatory responses to hypoxiahypoxia
title_fullStr HIF-1 activation and inflammatory responses to hypoxiahypoxia
title_full_unstemmed HIF-1 activation and inflammatory responses to hypoxiahypoxia
title_sort hif-1 activation and inflammatory responses to hypoxiahypoxia
publisher Embry-Riddle Aeronautical University
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/108172/
https://commons.erau.edu/ijaaa/vol10/iss2/3/
_version_ 1811686003138625536
score 13.211869

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