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Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury

Knee injuries are musculoskeletal system injuries, including the Anterior Cruciate Ligament (ACL). ACL injuries are most common in athletes. This ACL injury necessitates biomaterial replacement. It is sometimes taken from the patient's tendon and a biomaterial scaffold is used. The use of bioma...

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Main Authors: Aminatun, None, Hanum S, Faika, Izak R, Djoni, Hadi, Sofijan, Amrillah, Tahta, Che Abdullah, Che Azurahanim
Format: Article
Language:English
Published: Royal Society of Chemistry 2023
Online Access:http://psasir.upm.edu.my/id/eprint/107921/1/107921.pdf
http://psasir.upm.edu.my/id/eprint/107921/
https://pubs.rsc.org/en/content/articlelanding/2023/ra/d2ra07756f
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spelling my.upm.eprints.1079212025-03-05T01:05:45Z http://psasir.upm.edu.my/id/eprint/107921/ Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury Aminatun, None Hanum S, Faika Izak R, Djoni Hadi, Sofijan Amrillah, Tahta Che Abdullah, Che Azurahanim Knee injuries are musculoskeletal system injuries, including the Anterior Cruciate Ligament (ACL). ACL injuries are most common in athletes. This ACL injury necessitates biomaterial replacement. It is sometimes taken from the patient's tendon and a biomaterial scaffold is used. The use of biomaterial scaffolds as artificial ACLs remains to be investigated. The purpose of this study is to determine the properties of an ACL scaffold made of polycaprolactone (PCL)-hydroxyapatite (HA) and collagen with various composition variations of (50 : 45 : 5), (50 : 40 : 10), (50 : 35 : 15), (50 : 30 : 20), and (50 : 25 : 25) wt%. The scaffold was created using the electrospinning method with a voltage of 23 kV, a needle-collector distance of 15 cm, and a solution flow rate of 2 mL h−1. The average fiber diameter in all samples was less than 1000 nm. The model with the best characterization was PCL : HA : collagen with a weight-to-weight (wt%) ratio of 50 : 45 : 5 and an average fiber diameter of 488 ± 271 nm. The UTS and modulus of elasticity for braided samples were 2.796 MPa and 3.224 MPa, respectively, while the non-braided samples were 2.864 MPa and 12.942 MPa. The estimated time of degradation was 9.44 months. It was also revealed to be non-toxic, with an 87.95% viable cell percentage. Royal Society of Chemistry 2023 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/107921/1/107921.pdf Aminatun, None and Hanum S, Faika and Izak R, Djoni and Hadi, Sofijan and Amrillah, Tahta and Che Abdullah, Che Azurahanim (2023) Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury. RSC Advances, 13 (16). pp. 10459-10467. ISSN 2046-2069; eISSN: 2046-2069 https://pubs.rsc.org/en/content/articlelanding/2023/ra/d2ra07756f 10.1039/d2ra07756f
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Knee injuries are musculoskeletal system injuries, including the Anterior Cruciate Ligament (ACL). ACL injuries are most common in athletes. This ACL injury necessitates biomaterial replacement. It is sometimes taken from the patient's tendon and a biomaterial scaffold is used. The use of biomaterial scaffolds as artificial ACLs remains to be investigated. The purpose of this study is to determine the properties of an ACL scaffold made of polycaprolactone (PCL)-hydroxyapatite (HA) and collagen with various composition variations of (50 : 45 : 5), (50 : 40 : 10), (50 : 35 : 15), (50 : 30 : 20), and (50 : 25 : 25) wt%. The scaffold was created using the electrospinning method with a voltage of 23 kV, a needle-collector distance of 15 cm, and a solution flow rate of 2 mL h−1. The average fiber diameter in all samples was less than 1000 nm. The model with the best characterization was PCL : HA : collagen with a weight-to-weight (wt%) ratio of 50 : 45 : 5 and an average fiber diameter of 488 ± 271 nm. The UTS and modulus of elasticity for braided samples were 2.796 MPa and 3.224 MPa, respectively, while the non-braided samples were 2.864 MPa and 12.942 MPa. The estimated time of degradation was 9.44 months. It was also revealed to be non-toxic, with an 87.95% viable cell percentage.
format Article
author Aminatun, None
Hanum S, Faika
Izak R, Djoni
Hadi, Sofijan
Amrillah, Tahta
Che Abdullah, Che Azurahanim
spellingShingle Aminatun, None
Hanum S, Faika
Izak R, Djoni
Hadi, Sofijan
Amrillah, Tahta
Che Abdullah, Che Azurahanim
Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
author_facet Aminatun, None
Hanum S, Faika
Izak R, Djoni
Hadi, Sofijan
Amrillah, Tahta
Che Abdullah, Che Azurahanim
author_sort Aminatun, None
title Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
title_short Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
title_full Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
title_fullStr Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
title_full_unstemmed Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
title_sort fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
publisher Royal Society of Chemistry
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/107921/1/107921.pdf
http://psasir.upm.edu.my/id/eprint/107921/
https://pubs.rsc.org/en/content/articlelanding/2023/ra/d2ra07756f
_version_ 1825810689985347584
score 13.244413

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