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An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats

One hypothesis that has gained attention for the occurrence of obesity is due to the reaction of the microorganisms in our gut. It has been established that the food intake and dietary composition modulates the composition of the gut microbiota. The main aim for the study is to determine the potenti...

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Main Authors: Thompson, Mayrilyn Solo, Hui Yan, Tan, Mikal, Kathleen Michelle, Shamsudin, Shafarin Mohammad, Rashed, Aswir, Sarbini, Shahrul Razid
Format: Article
Published: Elsevier 2023
Online Access:http://psasir.upm.edu.my/id/eprint/106582/
https://www.sciencedirect.com/science/article/pii/S2212619823000190
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spelling my.upm.eprints.1065822024-09-26T07:49:15Z http://psasir.upm.edu.my/id/eprint/106582/ An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats Thompson, Mayrilyn Solo Hui Yan, Tan Mikal, Kathleen Michelle Shamsudin, Shafarin Mohammad Rashed, Aswir Sarbini, Shahrul Razid One hypothesis that has gained attention for the occurrence of obesity is due to the reaction of the microorganisms in our gut. It has been established that the food intake and dietary composition modulates the composition of the gut microbiota. The main aim for the study is to determine the potential of sago starch as prebiotic. Whereby, sago starch is one of the major commodities in East Malaysia, that derived from sago palm tree and contains high resistant starch. This study also evaluates the range for low dosage of resistant starch from sago starch that can confers health benefit on the fat-induced rats for its functional value. The Sprague Dawley rats was fat-induced prior to resistant starch intervention. Fecal samples were collected every two weeks. Short-chain fatty acids production was analyzed using high performance liquid chromatography, and gut microbiota quantification using fluorescent in-situ hybridization method. The finding showed that Bifidobacterium spp. and Lactobacillus spp. showed significant increment (P<0.05) when supplement with sago starch. Short chain fatty acids such as acetate, propionate and butyrate showed increment trends, however not significant. Thus, the study demonstrated that sago starch has similar effect with the commercially available resistant starch indicating the potential as prebiotic. Elsevier 2023 Article PeerReviewed Thompson, Mayrilyn Solo and Hui Yan, Tan and Mikal, Kathleen Michelle and Shamsudin, Shafarin Mohammad and Rashed, Aswir and Sarbini, Shahrul Razid (2023) An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats. Bioactive Carbohydrates and Dietary Fibre, 30. art. no. 100365. pp. 1-8. ISSN 2212-6198 https://www.sciencedirect.com/science/article/pii/S2212619823000190 10.1016/j.bcdf.2023.100365
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description One hypothesis that has gained attention for the occurrence of obesity is due to the reaction of the microorganisms in our gut. It has been established that the food intake and dietary composition modulates the composition of the gut microbiota. The main aim for the study is to determine the potential of sago starch as prebiotic. Whereby, sago starch is one of the major commodities in East Malaysia, that derived from sago palm tree and contains high resistant starch. This study also evaluates the range for low dosage of resistant starch from sago starch that can confers health benefit on the fat-induced rats for its functional value. The Sprague Dawley rats was fat-induced prior to resistant starch intervention. Fecal samples were collected every two weeks. Short-chain fatty acids production was analyzed using high performance liquid chromatography, and gut microbiota quantification using fluorescent in-situ hybridization method. The finding showed that Bifidobacterium spp. and Lactobacillus spp. showed significant increment (P<0.05) when supplement with sago starch. Short chain fatty acids such as acetate, propionate and butyrate showed increment trends, however not significant. Thus, the study demonstrated that sago starch has similar effect with the commercially available resistant starch indicating the potential as prebiotic.
format Article
author Thompson, Mayrilyn Solo
Hui Yan, Tan
Mikal, Kathleen Michelle
Shamsudin, Shafarin Mohammad
Rashed, Aswir
Sarbini, Shahrul Razid
spellingShingle Thompson, Mayrilyn Solo
Hui Yan, Tan
Mikal, Kathleen Michelle
Shamsudin, Shafarin Mohammad
Rashed, Aswir
Sarbini, Shahrul Razid
An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats
author_facet Thompson, Mayrilyn Solo
Hui Yan, Tan
Mikal, Kathleen Michelle
Shamsudin, Shafarin Mohammad
Rashed, Aswir
Sarbini, Shahrul Razid
author_sort Thompson, Mayrilyn Solo
title An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats
title_short An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats
title_full An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats
title_fullStr An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats
title_full_unstemmed An in vivo study: prebiotic evaluation of the resistant starch from Metroxylon sagu on obesity using fat-induced rats
title_sort in vivo study: prebiotic evaluation of the resistant starch from metroxylon sagu on obesity using fat-induced rats
publisher Elsevier
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/106582/
https://www.sciencedirect.com/science/article/pii/S2212619823000190
_version_ 1811685943638228992
score 13.211869

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