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Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis

Background: Traditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing the incidence of HCC in patients with chronic hepatitis B-related cirrhosis remains unclear. This study a...

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Main Authors: Tu, An, Zhu, Xiaoning, Dastjerdi, Paniz Zarghami, Yin, Yue, Peng, Mengyun, Zheng, Ding, Peng, Zhaoxuan, Wang, Encheng, Wang, Xiaodong, Jing, Wang
Format: Article
Language:English
Published: Elsevier Ltd 2024
Online Access:http://psasir.upm.edu.my/id/eprint/106166/1/1-s2.0-S2405844024004687-main.pdf
http://psasir.upm.edu.my/id/eprint/106166/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183867994&url=10.1016%2fj.heliyon.2024.e24437&partnerID=40&md5=cd9c8b6c2ac96691375e179b71d0979a
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spelling my.upm.eprints.1061662024-09-03T08:22:12Z http://psasir.upm.edu.my/id/eprint/106166/ Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis Tu, An Zhu, Xiaoning Dastjerdi, Paniz Zarghami Yin, Yue Peng, Mengyun Zheng, Ding Peng, Zhaoxuan Wang, Encheng Wang, Xiaodong Jing, Wang Background: Traditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing the incidence of HCC in patients with chronic hepatitis B-related cirrhosis remains unclear. This study aims to address this gap. Methods: Publications were collected from PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Sino Med, VIP, and Wan Fang Databases. Relative risk (RR) was calculated with a 95 confidence interval (CI). Heterogeneity was assessed. The Cochrane Collaboration's tool was used to assess the risk of bias. Results: 10 studies with 2702 patients showed that the combination therapy significantly reduced the incidence of HCC in patients with post-hepatitis B cirrhosis at 1, 3, and 5 years. However, the preventive effects of TCM were in compensated cirrhosis, but not the decompensated cirrhosis. Furthermore, TCM correlated with improved liver function and enhanced virological response. Conclusion: Combination therapy with TCM demonstrated the certain potential in reducing the incidence of HCC in patients with hepatitis B cirrhosis. This is attrinuted to the improvement of liver function and enhancement of the viral response. However, the efficacy of TCM in the field still needs more high-quality RCTs to provide stronger evidence in the future. Elsevier Ltd 2024-02 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/106166/1/1-s2.0-S2405844024004687-main.pdf Tu, An and Zhu, Xiaoning and Dastjerdi, Paniz Zarghami and Yin, Yue and Peng, Mengyun and Zheng, Ding and Peng, Zhaoxuan and Wang, Encheng and Wang, Xiaodong and Jing, Wang (2024) Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis. Heliyon, 10 (3). art. no. e24437. pp. 1-12. ISSN 2405-8440 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183867994&url=10.1016%2fj.heliyon.2024.e24437&partnerID=40&md5=cd9c8b6c2ac96691375e179b71d0979a 10.1016/j.heliyon.2024.e24437
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: Traditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing the incidence of HCC in patients with chronic hepatitis B-related cirrhosis remains unclear. This study aims to address this gap. Methods: Publications were collected from PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Sino Med, VIP, and Wan Fang Databases. Relative risk (RR) was calculated with a 95 confidence interval (CI). Heterogeneity was assessed. The Cochrane Collaboration's tool was used to assess the risk of bias. Results: 10 studies with 2702 patients showed that the combination therapy significantly reduced the incidence of HCC in patients with post-hepatitis B cirrhosis at 1, 3, and 5 years. However, the preventive effects of TCM were in compensated cirrhosis, but not the decompensated cirrhosis. Furthermore, TCM correlated with improved liver function and enhanced virological response. Conclusion: Combination therapy with TCM demonstrated the certain potential in reducing the incidence of HCC in patients with hepatitis B cirrhosis. This is attrinuted to the improvement of liver function and enhancement of the viral response. However, the efficacy of TCM in the field still needs more high-quality RCTs to provide stronger evidence in the future.
format Article
author Tu, An
Zhu, Xiaoning
Dastjerdi, Paniz Zarghami
Yin, Yue
Peng, Mengyun
Zheng, Ding
Peng, Zhaoxuan
Wang, Encheng
Wang, Xiaodong
Jing, Wang
spellingShingle Tu, An
Zhu, Xiaoning
Dastjerdi, Paniz Zarghami
Yin, Yue
Peng, Mengyun
Zheng, Ding
Peng, Zhaoxuan
Wang, Encheng
Wang, Xiaodong
Jing, Wang
Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
author_facet Tu, An
Zhu, Xiaoning
Dastjerdi, Paniz Zarghami
Yin, Yue
Peng, Mengyun
Zheng, Ding
Peng, Zhaoxuan
Wang, Encheng
Wang, Xiaodong
Jing, Wang
author_sort Tu, An
title Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
title_short Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
title_full Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
title_fullStr Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
title_full_unstemmed Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
title_sort evaluate the clinical efficacy of traditional chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis b-related cirrhosis: a systematic review and meta-analysis
publisher Elsevier Ltd
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/106166/1/1-s2.0-S2405844024004687-main.pdf
http://psasir.upm.edu.my/id/eprint/106166/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183867994&url=10.1016%2fj.heliyon.2024.e24437&partnerID=40&md5=cd9c8b6c2ac96691375e179b71d0979a
_version_ 1811685932477186048
score 13.211869

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