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Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)

The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this...

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Main Authors: Whba, Fathyah, Mohamed, Faizal, Idris, Mohd Idzat, Whba, Rawdah, Mohd Noor, Noramaliza
Format: Article
Language:English
Published: Korean Nuclear Society 2024
Online Access:http://psasir.upm.edu.my/id/eprint/105845/1/1-s2.0-S1738573323005892-main.pdf
http://psasir.upm.edu.my/id/eprint/105845/
https://www.sciencedirect.com/science/article/pii/S1738573323005892
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spelling my.upm.eprints.1058452024-07-12T07:16:05Z http://psasir.upm.edu.my/id/eprint/105845/ Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI) Whba, Fathyah Mohamed, Faizal Idris, Mohd Idzat Whba, Rawdah Mohd Noor, Noramaliza The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this issue. Therefore, this research aimed to develop a biocompatible, dispersible, stable, hydrophilic, and less toxic cellulose nanocrystals/gadolinium oxide nanocomposite as contrast agent properties for MRI purposes. This study aimed to synthesize gadolinium oxide nanoparticles coated with cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH)/Gd2O3 using the gamma irradiation method to reduce the particle size. The results showed that using a gamma irradiation dose of 10 kGy, quasi-spherical morphology with a size of approximately 5.5 ± 0.65 nm could be produced. Furthermore, the cytocompatibility of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite synthesized was assessed through MTT assay tests on Hep G2 cells, which demonstrated good cytocompatibility without any cytotoxic effects within a concentration range of (10 μg/mL −150 μg/mL) and had sufficient cellular uptake. Moreover, the T1-weighted MRI of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite revealed promising results as a positive contrast agent. It is envisaged that the gamma irradiation method is promising in synthesizing (CNCs-PEG/NaOH)/Gd2O3 nanocomposite with nanoscale for different applications, especially in the radiotherapy field. Korean Nuclear Society 2024 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/105845/1/1-s2.0-S1738573323005892-main.pdf Whba, Fathyah and Mohamed, Faizal and Idris, Mohd Idzat and Whba, Rawdah and Mohd Noor, Noramaliza (2024) Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI). Nuclear Engineering and Technology. pp. 1-10. ISSN 1738-5733; ESSN: 2234-358X (In Press) https://www.sciencedirect.com/science/article/pii/S1738573323005892 10.1016/j.net.2023.12.037
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this issue. Therefore, this research aimed to develop a biocompatible, dispersible, stable, hydrophilic, and less toxic cellulose nanocrystals/gadolinium oxide nanocomposite as contrast agent properties for MRI purposes. This study aimed to synthesize gadolinium oxide nanoparticles coated with cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH)/Gd2O3 using the gamma irradiation method to reduce the particle size. The results showed that using a gamma irradiation dose of 10 kGy, quasi-spherical morphology with a size of approximately 5.5 ± 0.65 nm could be produced. Furthermore, the cytocompatibility of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite synthesized was assessed through MTT assay tests on Hep G2 cells, which demonstrated good cytocompatibility without any cytotoxic effects within a concentration range of (10 μg/mL −150 μg/mL) and had sufficient cellular uptake. Moreover, the T1-weighted MRI of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite revealed promising results as a positive contrast agent. It is envisaged that the gamma irradiation method is promising in synthesizing (CNCs-PEG/NaOH)/Gd2O3 nanocomposite with nanoscale for different applications, especially in the radiotherapy field.
format Article
author Whba, Fathyah
Mohamed, Faizal
Idris, Mohd Idzat
Whba, Rawdah
Mohd Noor, Noramaliza
spellingShingle Whba, Fathyah
Mohamed, Faizal
Idris, Mohd Idzat
Whba, Rawdah
Mohd Noor, Noramaliza
Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)
author_facet Whba, Fathyah
Mohamed, Faizal
Idris, Mohd Idzat
Whba, Rawdah
Mohd Noor, Noramaliza
author_sort Whba, Fathyah
title Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)
title_short Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)
title_full Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)
title_fullStr Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)
title_full_unstemmed Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)
title_sort effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/gd2o3 nanocomposite as contrast agent in magnetic resonance imaging (mri)
publisher Korean Nuclear Society
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/105845/1/1-s2.0-S1738573323005892-main.pdf
http://psasir.upm.edu.my/id/eprint/105845/
https://www.sciencedirect.com/science/article/pii/S1738573323005892
_version_ 1805889522927403008
score 13.211869

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