Staff View: Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron

Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron

Due to increased demand, cyclotron has an expanding role in producing Gallium-68 (68Ga) radiopharmaceuticals using solid and liquid targets. Though the liquid target produces lower end-of-bombardment activity compared to the solid target, our study presents the performance of 68Ga radiopharmaceutica...

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Main Authors:	Ashhar, Zarif, Ahmad Fadzil, Muhammad Fakhrurazi, Md Safee, Zaitulhusna, Aziz, Firdaus, Ibarhim, Ummi Habibah, Nik Afinde, Nik Muhammad Fitri, Mat Ail, Noratikah, Jamal Harizan, Muhammad Ali Hazizi, Halib, Dzulieza, Alek Amran, Arieffuddin, Adawiyah, Rabiatul, Abd Hamid, Mohd Hamdi Noor, Mahamood, Mazurin, Razali, Nor Idayu, Said, Mohamad Aminudin
Format:	Article
Published:	Elsevier 2024
Online Access:	http://psasir.upm.edu.my/id/eprint/105669/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181677046&doi=10.1016%2fj.apradiso.2023.111161&partnerID=40&md5=24b6cda6e36934e80f555173c530027f
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spelling	my.upm.eprints.1056692024-02-08T03:13:20Z http://psasir.upm.edu.my/id/eprint/105669/ Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron Ashhar, Zarif Ahmad Fadzil, Muhammad Fakhrurazi Md Safee, Zaitulhusna Aziz, Firdaus Ibarhim, Ummi Habibah Nik Afinde, Nik Muhammad Fitri Mat Ail, Noratikah Jamal Harizan, Muhammad Ali Hazizi Halib, Dzulieza Alek Amran, Arieffuddin Adawiyah, Rabiatul Abd Hamid, Mohd Hamdi Noor Mahamood, Mazurin Razali, Nor Idayu Said, Mohamad Aminudin Due to increased demand, cyclotron has an expanding role in producing Gallium-68 (68Ga) radiopharmaceuticals using solid and liquid targets. Though the liquid target produces lower end-of-bombardment activity compared to the solid target, our study presents the performance of 68Ga radiopharmaceuticals production using the liquid target by evaluating the end-of-bombardment activity and the end-of-purification activity of 68GaGaCl3. We also present the effect of increasing irradiation time, which significantly improves the end-of-synthesis yield. From the result obtained, the end-of-bombardment activity produced was 4.48 GBq, and the 68GaGaCl3 end-of-purification activity produced was 2.51 GBq with below-limit metallic impurities. Increasing the irradiation time showed a significant increase in the end-of-synthesis activity from 1.33 GBq to 1.95 GBq for 68GaGa-PSMA-11 and from 1.13 GBq to 1.74 GBq for 68GaGa-DOTA-TATE. Based on the improvements made, the liquid target production of 68Ga radiopharmaceuticals is feasible and reproducible to accommodate up to 5 patients per production. In addition, this work also discusses the issues encountered, together with the possible corrective and preventative measures. © 2023 Elsevier Ltd Elsevier 2024-12 Article PeerReviewed Ashhar, Zarif and Ahmad Fadzil, Muhammad Fakhrurazi and Md Safee, Zaitulhusna and Aziz, Firdaus and Ibarhim, Ummi Habibah and Nik Afinde, Nik Muhammad Fitri and Mat Ail, Noratikah and Jamal Harizan, Muhammad Ali Hazizi and Halib, Dzulieza and Alek Amran, Arieffuddin and Adawiyah, Rabiatul and Abd Hamid, Mohd Hamdi Noor and Mahamood, Mazurin and Razali, Nor Idayu and Said, Mohamad Aminudin (2024) Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron. Applied Radiation and Isotopes, 205. art. no. 111161. pp. 1-10. ISSN 0969-8043; ESSN: 1872-9800 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181677046&doi=10.1016%2fj.apradiso.2023.111161&partnerID=40&md5=24b6cda6e36934e80f555173c530027f 10.1016/j.apradiso.2023.111161
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	Due to increased demand, cyclotron has an expanding role in producing Gallium-68 (68Ga) radiopharmaceuticals using solid and liquid targets. Though the liquid target produces lower end-of-bombardment activity compared to the solid target, our study presents the performance of 68Ga radiopharmaceuticals production using the liquid target by evaluating the end-of-bombardment activity and the end-of-purification activity of 68GaGaCl3. We also present the effect of increasing irradiation time, which significantly improves the end-of-synthesis yield. From the result obtained, the end-of-bombardment activity produced was 4.48 GBq, and the 68GaGaCl3 end-of-purification activity produced was 2.51 GBq with below-limit metallic impurities. Increasing the irradiation time showed a significant increase in the end-of-synthesis activity from 1.33 GBq to 1.95 GBq for 68GaGa-PSMA-11 and from 1.13 GBq to 1.74 GBq for 68GaGa-DOTA-TATE. Based on the improvements made, the liquid target production of 68Ga radiopharmaceuticals is feasible and reproducible to accommodate up to 5 patients per production. In addition, this work also discusses the issues encountered, together with the possible corrective and preventative measures. © 2023 Elsevier Ltd
format	Article
author	Ashhar, Zarif Ahmad Fadzil, Muhammad Fakhrurazi Md Safee, Zaitulhusna Aziz, Firdaus Ibarhim, Ummi Habibah Nik Afinde, Nik Muhammad Fitri Mat Ail, Noratikah Jamal Harizan, Muhammad Ali Hazizi Halib, Dzulieza Alek Amran, Arieffuddin Adawiyah, Rabiatul Abd Hamid, Mohd Hamdi Noor Mahamood, Mazurin Razali, Nor Idayu Said, Mohamad Aminudin
spellingShingle	Ashhar, Zarif Ahmad Fadzil, Muhammad Fakhrurazi Md Safee, Zaitulhusna Aziz, Firdaus Ibarhim, Ummi Habibah Nik Afinde, Nik Muhammad Fitri Mat Ail, Noratikah Jamal Harizan, Muhammad Ali Hazizi Halib, Dzulieza Alek Amran, Arieffuddin Adawiyah, Rabiatul Abd Hamid, Mohd Hamdi Noor Mahamood, Mazurin Razali, Nor Idayu Said, Mohamad Aminudin Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
author_facet	Ashhar, Zarif Ahmad Fadzil, Muhammad Fakhrurazi Md Safee, Zaitulhusna Aziz, Firdaus Ibarhim, Ummi Habibah Nik Afinde, Nik Muhammad Fitri Mat Ail, Noratikah Jamal Harizan, Muhammad Ali Hazizi Halib, Dzulieza Alek Amran, Arieffuddin Adawiyah, Rabiatul Abd Hamid, Mohd Hamdi Noor Mahamood, Mazurin Razali, Nor Idayu Said, Mohamad Aminudin
author_sort	Ashhar, Zarif
title	Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
title_short	Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
title_full	Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
title_fullStr	Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
title_full_unstemmed	Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron
title_sort	performance evaluation of gallium-68 radiopharmaceuticals production using liquid target pettrace 800 cyclotron
publisher	Elsevier
publishDate	2024
url	http://psasir.upm.edu.my/id/eprint/105669/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181677046&doi=10.1016%2fj.apradiso.2023.111161&partnerID=40&md5=24b6cda6e36934e80f555173c530027f
_version_	1792154551086743552
score	13.211869

Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron

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