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Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats

In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/...

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Main Authors: Hardiany, Novi Silvia, Dewi, Putri Krishna Kumara, Dewi, Syarifah, Tejo, Bimo A.
Format: Article
Published: Nature Research 2024
Online Access:http://psasir.upm.edu.my/id/eprint/105629/
https://www.nature.com/articles/s41598-024-51221-5?error=cookies_not_supported&code=9a8df4c6-59b9-48ae-bc99-cc30a3759e08
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spelling my.upm.eprints.1056292024-05-09T03:28:50Z http://psasir.upm.edu.my/id/eprint/105629/ Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats Hardiany, Novi Silvia Dewi, Putri Krishna Kumara Dewi, Syarifah Tejo, Bimo A. In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent. Nature Research 2024-01 Article PeerReviewed Hardiany, Novi Silvia and Dewi, Putri Krishna Kumara and Dewi, Syarifah and Tejo, Bimo A. (2024) Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats. Scientific Reports, 14 (1). art. no. 603. ISSN 2045-2322 https://www.nature.com/articles/s41598-024-51221-5?error=cookies_not_supported&code=9a8df4c6-59b9-48ae-bc99-cc30a3759e08 10.1038/s41598-024-51221-5
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent.
format Article
author Hardiany, Novi Silvia
Dewi, Putri Krishna Kumara
Dewi, Syarifah
Tejo, Bimo A.
spellingShingle Hardiany, Novi Silvia
Dewi, Putri Krishna Kumara
Dewi, Syarifah
Tejo, Bimo A.
Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
author_facet Hardiany, Novi Silvia
Dewi, Putri Krishna Kumara
Dewi, Syarifah
Tejo, Bimo A.
author_sort Hardiany, Novi Silvia
title Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
title_short Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
title_full Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
title_fullStr Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
title_full_unstemmed Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
title_sort exploration of neuroprotective effect from coriandrum sativum l. ethanolic seeds extracts on brain of obese rats
publisher Nature Research
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/105629/
https://www.nature.com/articles/s41598-024-51221-5?error=cookies_not_supported&code=9a8df4c6-59b9-48ae-bc99-cc30a3759e08
_version_ 1800093781852160000
score 13.211869

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