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Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients

Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of the new generation of anti-CCP antibodies (anti-CCP2 IgG, ant...

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Main Authors: Azalan, Maryam Syahidah, Wan Mohamad, Wan Majdiah, Saddki, Norkhafizah, Wan Ghazali, Wan Syamimee
Format: Article
Language:English
Published: Faculty of Medicine and Health Science, Universiti Putra Malaysia 2023
Online Access:http://psasir.upm.edu.my/id/eprint/105583/1/2023011613163113_MJMHS_0468.pdf
http://psasir.upm.edu.my/id/eprint/105583/
https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_1_january_2023-70882
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spelling my.upm.eprints.1055832024-01-29T03:00:19Z http://psasir.upm.edu.my/id/eprint/105583/ Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients Azalan, Maryam Syahidah Wan Mohamad, Wan Majdiah Saddki, Norkhafizah Wan Ghazali, Wan Syamimee Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of the new generation of anti-CCP antibodies (anti-CCP2 IgG, anti-CCP2 IgA and anti-CCP3.1 IgG/IgA) and their association with disease severity and functional status of RA patients. Methods: A total of 46 RA patients and 40 healthy controls participated in this cross-sectional study that was conducted at the Rheumatology Clinic, Hospital Universiti Sains Malaysia. Blood samples were taken from all participants for anti-CCP2 IgG, anti-CCP2 IgA, and anti-CCP3.1 IgG/IgA analysis. Disease severity and functional status of RA patients were measured using the Disease Activity Score-28 (DAS28) and the modified Health Assessment Questionnaire (mHAQ) respectively. Results: Significantly higher proportion of RA patients were found with positive anti-CCP2 IgG (63.0%), anti-CCP2 IgA (37.0%), and anti-CCP3.1 IgG/IgA antibodies (63.0%) than the healthy controls. No significant association was found between anti-CCP antibodies status and mean DAS28 score of the RA patients. However, RA patients with negative anti-CCP2 IgG status had higher mean mHAQ score than patients with positive anti-CCP2 IgG status. Conclusion: Our study has demonstrated detection of the new generation anti-CCP antibodies in RA patients, supporting the use of autoantibodies in RA diagnosis. While no significant association was found between the presence of anti-CCP antibodies and disease severity of RA patients, the absence of anti-CCP2 IgG was associated with worse function and greater disability of the patients. Faculty of Medicine and Health Science, Universiti Putra Malaysia 2023-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/105583/1/2023011613163113_MJMHS_0468.pdf Azalan, Maryam Syahidah and Wan Mohamad, Wan Majdiah and Saddki, Norkhafizah and Wan Ghazali, Wan Syamimee (2023) Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients. Malaysian Journal of Medicine and Health Sciences, 19 (1). pp. 96-101. ISSN 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_1_january_2023-70882 10.47836/mjmhs19.1.14
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) is associated with higher disease activity and lower functional ability. This study investigated the presence of the new generation of anti-CCP antibodies (anti-CCP2 IgG, anti-CCP2 IgA and anti-CCP3.1 IgG/IgA) and their association with disease severity and functional status of RA patients. Methods: A total of 46 RA patients and 40 healthy controls participated in this cross-sectional study that was conducted at the Rheumatology Clinic, Hospital Universiti Sains Malaysia. Blood samples were taken from all participants for anti-CCP2 IgG, anti-CCP2 IgA, and anti-CCP3.1 IgG/IgA analysis. Disease severity and functional status of RA patients were measured using the Disease Activity Score-28 (DAS28) and the modified Health Assessment Questionnaire (mHAQ) respectively. Results: Significantly higher proportion of RA patients were found with positive anti-CCP2 IgG (63.0%), anti-CCP2 IgA (37.0%), and anti-CCP3.1 IgG/IgA antibodies (63.0%) than the healthy controls. No significant association was found between anti-CCP antibodies status and mean DAS28 score of the RA patients. However, RA patients with negative anti-CCP2 IgG status had higher mean mHAQ score than patients with positive anti-CCP2 IgG status. Conclusion: Our study has demonstrated detection of the new generation anti-CCP antibodies in RA patients, supporting the use of autoantibodies in RA diagnosis. While no significant association was found between the presence of anti-CCP antibodies and disease severity of RA patients, the absence of anti-CCP2 IgG was associated with worse function and greater disability of the patients.
format Article
author Azalan, Maryam Syahidah
Wan Mohamad, Wan Majdiah
Saddki, Norkhafizah
Wan Ghazali, Wan Syamimee
spellingShingle Azalan, Maryam Syahidah
Wan Mohamad, Wan Majdiah
Saddki, Norkhafizah
Wan Ghazali, Wan Syamimee
Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
author_facet Azalan, Maryam Syahidah
Wan Mohamad, Wan Majdiah
Saddki, Norkhafizah
Wan Ghazali, Wan Syamimee
author_sort Azalan, Maryam Syahidah
title Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
title_short Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
title_full Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
title_fullStr Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
title_full_unstemmed Association of new generation anti-CCP antibodies with disease severity and functional status in rheumatoid arthritis patients
title_sort association of new generation anti-ccp antibodies with disease severity and functional status in rheumatoid arthritis patients
publisher Faculty of Medicine and Health Science, Universiti Putra Malaysia
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/105583/1/2023011613163113_MJMHS_0468.pdf
http://psasir.upm.edu.my/id/eprint/105583/
https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_1_january_2023-70882
_version_ 1789426935841947648
score 13.211869

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