Cover Image

Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination

The emergence of SARS-CoV-2 variants raises concerns of reduced COVID-19 vaccine efficacy. We investigated the humoral immunity in uninfected and previously infected ChAdOx1 nCoV-19, BNT162b2 and CoronaVac vaccinees, who have received complete regimes of vaccines by means of a SARS-CoV-2 surrogate v...

Full description

Saved in:
Bibliographic Details
Main Authors: Chua, Jia Xin, Durrant, Lindy Gillian, Chok, Yin Ling, Lai, Oi Ming
Format: Article
Published: Cell Press 2022
Online Access:http://psasir.upm.edu.my/id/eprint/103373/
https://www.sciencedirect.com/science/article/pii/S2589004222016510
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.103373
record_format eprints
spelling my.upm.eprints.1033732023-06-14T02:54:24Z http://psasir.upm.edu.my/id/eprint/103373/ Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination Chua, Jia Xin Durrant, Lindy Gillian Chok, Yin Ling Lai, Oi Ming The emergence of SARS-CoV-2 variants raises concerns of reduced COVID-19 vaccine efficacy. We investigated the humoral immunity in uninfected and previously infected ChAdOx1 nCoV-19, BNT162b2 and CoronaVac vaccinees, who have received complete regimes of vaccines by means of a SARS-CoV-2 surrogate virus blocking test. The ChAdOx1 nCoV-19 (p = 0.0013) and BNT162b2 (p = 0.0005) vaccines induced significant higher blocking activity with longer durability against the Spike (S) protein receptor binding domain (RBD) of wild type SARS-CoV-2 than the CoronaVac vaccine in uninfected vaccinees. Prior infection improved protection in the CoronaVac vaccinees. Subsequent investigation on the breadth of SARS-CoV-2 vaccine-induced antibody blocking responses, revealed that all vaccine platforms cross-protected uninfected vaccinees against all variant of concerns, except Omicron. Prior infection protected the ChAdOx1 nCoV-19 and BNT162b2 vaccinees against Omicron but not CoronaVac vaccinees. Our study suggests that vaccines that induce broader sterilizing immunity are essential to fight against fast-emerging variants. Cell Press 2022 Article PeerReviewed Chua, Jia Xin and Durrant, Lindy Gillian and Chok, Yin Ling and Lai, Oi Ming (2022) Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination. iScience, 25 (11). art. no. 105379. pp. 1-24. ISSN 2589-0042 https://www.sciencedirect.com/science/article/pii/S2589004222016510 10.1016/j.isci.2022.105379
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The emergence of SARS-CoV-2 variants raises concerns of reduced COVID-19 vaccine efficacy. We investigated the humoral immunity in uninfected and previously infected ChAdOx1 nCoV-19, BNT162b2 and CoronaVac vaccinees, who have received complete regimes of vaccines by means of a SARS-CoV-2 surrogate virus blocking test. The ChAdOx1 nCoV-19 (p = 0.0013) and BNT162b2 (p = 0.0005) vaccines induced significant higher blocking activity with longer durability against the Spike (S) protein receptor binding domain (RBD) of wild type SARS-CoV-2 than the CoronaVac vaccine in uninfected vaccinees. Prior infection improved protection in the CoronaVac vaccinees. Subsequent investigation on the breadth of SARS-CoV-2 vaccine-induced antibody blocking responses, revealed that all vaccine platforms cross-protected uninfected vaccinees against all variant of concerns, except Omicron. Prior infection protected the ChAdOx1 nCoV-19 and BNT162b2 vaccinees against Omicron but not CoronaVac vaccinees. Our study suggests that vaccines that induce broader sterilizing immunity are essential to fight against fast-emerging variants.
format Article
author Chua, Jia Xin
Durrant, Lindy Gillian
Chok, Yin Ling
Lai, Oi Ming
spellingShingle Chua, Jia Xin
Durrant, Lindy Gillian
Chok, Yin Ling
Lai, Oi Ming
Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
author_facet Chua, Jia Xin
Durrant, Lindy Gillian
Chok, Yin Ling
Lai, Oi Ming
author_sort Chua, Jia Xin
title Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
title_short Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
title_full Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
title_fullStr Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
title_full_unstemmed Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
title_sort susceptibility to sars-cov-2 omicron following chadox1 ncov-19 and bnt162b2 versus coronavac vaccination
publisher Cell Press
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/103373/
https://www.sciencedirect.com/science/article/pii/S2589004222016510
_version_ 1769844455405256704
score 13.211869

Similar Items