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Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach

The mechanical heart valve (MHV) is commonly used for the treatment of cardiovascular diseases. Nonphysiological hemodynamic in the MHV may cause hemolysis, platelet activation, and an increased risk of thromboembolism. Thromboembolism may cause severe complications and valve dysfunction. This paper...

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Main Authors: Chen, Aolin, Basri, Adi Azriff, Ismail, Norzian, Tamagawa, Masaaki, Zhu, Di, Ahmad, Kamarul Arifin
Format: Article
Published: Hindawi Publishing 2022
Online Access:http://psasir.upm.edu.my/id/eprint/103203/
https://www.hindawi.com/journals/abb/2022/9612296/
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spelling my.upm.eprints.1032032023-11-23T04:57:59Z http://psasir.upm.edu.my/id/eprint/103203/ Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach Chen, Aolin Basri, Adi Azriff Ismail, Norzian Tamagawa, Masaaki Zhu, Di Ahmad, Kamarul Arifin The mechanical heart valve (MHV) is commonly used for the treatment of cardiovascular diseases. Nonphysiological hemodynamic in the MHV may cause hemolysis, platelet activation, and an increased risk of thromboembolism. Thromboembolism may cause severe complications and valve dysfunction. This paper thoroughly reviewed the simulation of physical quantities (velocity distribution, vortex formation, and shear stress) in healthy and dysfunctional MHV and reviewed the non-Newtonian blood flow characteristics in MHV. In the MHV numerical study, the dysfunction will affect the simulation results, increase the pressure gradient and shear stress, and change the blood flow patterns, increasing the risks of hemolysis and platelet activation. The blood flow passes downstream and has obvious recirculation and stagnation region with the increased dysfunction severity. Due to the complex structure of the MHV, the non-Newtonian shear-thinning viscosity blood characteristics become apparent in MHV simulations. The comparative study between Newtonian and non-Newtonian always shows the difference. The shear-thinning blood viscosity model is the basics to build the blood, also the blood exhibiting viscoelastic properties. More details are needed to establish a complete and more realistic simulation. Hindawi Publishing 2022 Article PeerReviewed Chen, Aolin and Basri, Adi Azriff and Ismail, Norzian and Tamagawa, Masaaki and Zhu, Di and Ahmad, Kamarul Arifin (2022) Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach. Applied Bionics and Biomechanics, 2022. art. no. 9612296. pp. 1-14. ISSN 1176-2322; ESSN: 1754-2103 https://www.hindawi.com/journals/abb/2022/9612296/ 10.1155/2022/9612296
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The mechanical heart valve (MHV) is commonly used for the treatment of cardiovascular diseases. Nonphysiological hemodynamic in the MHV may cause hemolysis, platelet activation, and an increased risk of thromboembolism. Thromboembolism may cause severe complications and valve dysfunction. This paper thoroughly reviewed the simulation of physical quantities (velocity distribution, vortex formation, and shear stress) in healthy and dysfunctional MHV and reviewed the non-Newtonian blood flow characteristics in MHV. In the MHV numerical study, the dysfunction will affect the simulation results, increase the pressure gradient and shear stress, and change the blood flow patterns, increasing the risks of hemolysis and platelet activation. The blood flow passes downstream and has obvious recirculation and stagnation region with the increased dysfunction severity. Due to the complex structure of the MHV, the non-Newtonian shear-thinning viscosity blood characteristics become apparent in MHV simulations. The comparative study between Newtonian and non-Newtonian always shows the difference. The shear-thinning blood viscosity model is the basics to build the blood, also the blood exhibiting viscoelastic properties. More details are needed to establish a complete and more realistic simulation.
format Article
author Chen, Aolin
Basri, Adi Azriff
Ismail, Norzian
Tamagawa, Masaaki
Zhu, Di
Ahmad, Kamarul Arifin
spellingShingle Chen, Aolin
Basri, Adi Azriff
Ismail, Norzian
Tamagawa, Masaaki
Zhu, Di
Ahmad, Kamarul Arifin
Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
author_facet Chen, Aolin
Basri, Adi Azriff
Ismail, Norzian
Tamagawa, Masaaki
Zhu, Di
Ahmad, Kamarul Arifin
author_sort Chen, Aolin
title Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
title_short Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
title_full Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
title_fullStr Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
title_full_unstemmed Simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
title_sort simulation of mechanical heart valve dysfunction and the non-newtonian blood model approach
publisher Hindawi Publishing
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/103203/
https://www.hindawi.com/journals/abb/2022/9612296/
_version_ 1783879941898633216
score 13.211869

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