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Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia

TB treatment interruption has resulted in delayed sputum conversion, drug resistance, and a high mortality rate and a prolonged treatment course, hence leading to economic and psychosocial affliction. To date, there are limited studies investigating the physico-social risk factors for early treatmen...

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Main Authors: Suliman, Qudsiah, Lim, Poh Ying, Md. Said, Salmiah, Tan, Kit-Aun, Mohd. Zulkefli, Nor Afiah
Format: Article
Published: Nature Research 2022
Online Access:http://psasir.upm.edu.my/id/eprint/103108/
https://www.nature.com/articles/s41598-021-04742-2?error=cookies_not_supported&code=c5212c45-dd30-4b5f-8665-b54fb6ef1b64
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spelling my.upm.eprints.1031082024-06-30T23:54:35Z http://psasir.upm.edu.my/id/eprint/103108/ Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia Suliman, Qudsiah Lim, Poh Ying Md. Said, Salmiah Tan, Kit-Aun Mohd. Zulkefli, Nor Afiah TB treatment interruption has resulted in delayed sputum conversion, drug resistance, and a high mortality rate and a prolonged treatment course, hence leading to economic and psychosocial affliction. To date, there are limited studies investigating the physico-social risk factors for early treatment interruptions. This prospective multicenter cohort study aimed to investigate the risk factors for early treatment interruption among new pulmonary tuberculosis (TB) smear-positive patients in Selangor, Malaysia. A total of 439 participants were recruited from 39 public treatment centres, 2018–2019. Multivariate Cox proportional hazard analyses were performed to analyse the risk factors for early treatment interruption. Of 439 participants, 104 (23.7%) had early treatment interruption, with 67.3% of early treatment interruption occurring in the first month of treatment. Being a current smoker and having a history of hospitalization, internalized stigma, low TB symptoms score, and waiting time spent at Directly Observed Treatment, Short-course centre were risk factors for early treatment interruption. An appropriate treatment adherence strategy is suggested to prioritize the high-risk group with high early treatment interruption. Efforts to quit smoking cessation programs and to promote stigma reduction interventions are crucial to reduce the probability of early treatment interruption. Nature Research 2022 Article PeerReviewed Suliman, Qudsiah and Lim, Poh Ying and Md. Said, Salmiah and Tan, Kit-Aun and Mohd. Zulkefli, Nor Afiah (2022) Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia. Scientific Reports, 12 (1). pp. 1-9. ISSN 2045-2322 https://www.nature.com/articles/s41598-021-04742-2?error=cookies_not_supported&code=c5212c45-dd30-4b5f-8665-b54fb6ef1b64 10.1038/s41598-021-04742-2
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description TB treatment interruption has resulted in delayed sputum conversion, drug resistance, and a high mortality rate and a prolonged treatment course, hence leading to economic and psychosocial affliction. To date, there are limited studies investigating the physico-social risk factors for early treatment interruptions. This prospective multicenter cohort study aimed to investigate the risk factors for early treatment interruption among new pulmonary tuberculosis (TB) smear-positive patients in Selangor, Malaysia. A total of 439 participants were recruited from 39 public treatment centres, 2018–2019. Multivariate Cox proportional hazard analyses were performed to analyse the risk factors for early treatment interruption. Of 439 participants, 104 (23.7%) had early treatment interruption, with 67.3% of early treatment interruption occurring in the first month of treatment. Being a current smoker and having a history of hospitalization, internalized stigma, low TB symptoms score, and waiting time spent at Directly Observed Treatment, Short-course centre were risk factors for early treatment interruption. An appropriate treatment adherence strategy is suggested to prioritize the high-risk group with high early treatment interruption. Efforts to quit smoking cessation programs and to promote stigma reduction interventions are crucial to reduce the probability of early treatment interruption.
format Article
author Suliman, Qudsiah
Lim, Poh Ying
Md. Said, Salmiah
Tan, Kit-Aun
Mohd. Zulkefli, Nor Afiah
spellingShingle Suliman, Qudsiah
Lim, Poh Ying
Md. Said, Salmiah
Tan, Kit-Aun
Mohd. Zulkefli, Nor Afiah
Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia
author_facet Suliman, Qudsiah
Lim, Poh Ying
Md. Said, Salmiah
Tan, Kit-Aun
Mohd. Zulkefli, Nor Afiah
author_sort Suliman, Qudsiah
title Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia
title_short Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia
title_full Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia
title_fullStr Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia
title_full_unstemmed Risk factors for early TB treatment interruption among newly diagnosed patients in Malaysia
title_sort risk factors for early tb treatment interruption among newly diagnosed patients in malaysia
publisher Nature Research
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/103108/
https://www.nature.com/articles/s41598-021-04742-2?error=cookies_not_supported&code=c5212c45-dd30-4b5f-8665-b54fb6ef1b64
_version_ 1804067031601905664
score 13.211869

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