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Ogilvie's syndrome - a complication of severe COVID-19 infection

A higher rate of gastrointestinal complications has been shown in COVID-19 patients admitted to the intensive care unit than their counterparts without COVID-19. Ogilvie’s syndrome or acute colonic pseudo-obstruction is described as colonic distension without mechanical obstruction, usually caused b...

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Main Authors: Chong, Collins, Ibrahim, Noor Airini, Abdul Maei, Ngazraini
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022
Online Access:http://psasir.upm.edu.my/id/eprint/102363/1/2022011912442555_MJMHS_0082.pdf
http://psasir.upm.edu.my/id/eprint/102363/
https://medic.upm.edu.my/upload/dokumen/2022011912442555_MJMHS_0082.pdf
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spelling my.upm.eprints.1023632023-06-08T02:12:19Z http://psasir.upm.edu.my/id/eprint/102363/ Ogilvie's syndrome - a complication of severe COVID-19 infection Chong, Collins Ibrahim, Noor Airini Abdul Maei, Ngazraini A higher rate of gastrointestinal complications has been shown in COVID-19 patients admitted to the intensive care unit than their counterparts without COVID-19. Ogilvie’s syndrome or acute colonic pseudo-obstruction is described as colonic distension without mechanical obstruction, usually caused by infections, opioid use, renal dysfunction, and electrolyte imbalance. We report a patient with Ogilvie’s syndrome probably secondary to COVID-19. The patient was a 51-year-old man diagnosed as category 5 COVID-19, requiring intensive care treatment and mechanical ventilation. He developed transverse colonic perforation following large bowel dilatation, for which laparotomy and colectomy were done. Unfortunately, he succumbed to death due to intrabdominal sepsis with multiorgan failure. Possible pathogenesis of ileus in severe COVID-19 infection includes viral-induced autonomic nervous system dysfunction, viral-induced gut inflammation mediated by ACE-2 receptors located on the enterocytes, and ischaemic endothelialitis. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/102363/1/2022011912442555_MJMHS_0082.pdf Chong, Collins and Ibrahim, Noor Airini and Abdul Maei, Ngazraini (2022) Ogilvie's syndrome - a complication of severe COVID-19 infection. Malaysian Journal of Medicine and Health Sciences, 18 (1). 375 - 377. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022011912442555_MJMHS_0082.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A higher rate of gastrointestinal complications has been shown in COVID-19 patients admitted to the intensive care unit than their counterparts without COVID-19. Ogilvie’s syndrome or acute colonic pseudo-obstruction is described as colonic distension without mechanical obstruction, usually caused by infections, opioid use, renal dysfunction, and electrolyte imbalance. We report a patient with Ogilvie’s syndrome probably secondary to COVID-19. The patient was a 51-year-old man diagnosed as category 5 COVID-19, requiring intensive care treatment and mechanical ventilation. He developed transverse colonic perforation following large bowel dilatation, for which laparotomy and colectomy were done. Unfortunately, he succumbed to death due to intrabdominal sepsis with multiorgan failure. Possible pathogenesis of ileus in severe COVID-19 infection includes viral-induced autonomic nervous system dysfunction, viral-induced gut inflammation mediated by ACE-2 receptors located on the enterocytes, and ischaemic endothelialitis.
format Article
author Chong, Collins
Ibrahim, Noor Airini
Abdul Maei, Ngazraini
spellingShingle Chong, Collins
Ibrahim, Noor Airini
Abdul Maei, Ngazraini
Ogilvie's syndrome - a complication of severe COVID-19 infection
author_facet Chong, Collins
Ibrahim, Noor Airini
Abdul Maei, Ngazraini
author_sort Chong, Collins
title Ogilvie's syndrome - a complication of severe COVID-19 infection
title_short Ogilvie's syndrome - a complication of severe COVID-19 infection
title_full Ogilvie's syndrome - a complication of severe COVID-19 infection
title_fullStr Ogilvie's syndrome - a complication of severe COVID-19 infection
title_full_unstemmed Ogilvie's syndrome - a complication of severe COVID-19 infection
title_sort ogilvie's syndrome - a complication of severe covid-19 infection
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/102363/1/2022011912442555_MJMHS_0082.pdf
http://psasir.upm.edu.my/id/eprint/102363/
https://medic.upm.edu.my/upload/dokumen/2022011912442555_MJMHS_0082.pdf
_version_ 1769844443890843648
score 13.211869

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