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Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable

Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therape...

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Main Authors: Barzegar Behrooz, Amir, Talaie, Zahra, Syahir, Amir
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2022
Online Access:http://psasir.upm.edu.my/id/eprint/102279/
https://www.mdpi.com/1999-4923/14/8/1697#
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spelling my.upm.eprints.1022792023-06-15T21:31:57Z http://psasir.upm.edu.my/id/eprint/102279/ Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable Barzegar Behrooz, Amir Talaie, Zahra Syahir, Amir Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therapeutic success for GBM has been restricted. Drug delivery based on nanocarriers and nanotechnology has the potential to be a handy tool in the continuing effort to combat the challenges of treating GBM. There are various new therapies being tested to extend survival time. Maximizing therapeutic effectiveness necessitates using many treatment modalities at once. In the fight against GBM, combination treatments outperform individual ones. Combination therapies may be enhanced by using nanotechnology-based delivery techniques. Nano-chemotherapy, nano-chemotherapy–radiation, nano-chemotherapy–phototherapy, and nano-chemotherapy–immunotherapy for GBM are the focus of the current review to shed light on the current status of innovative designs. Multidisciplinary Digital Publishing Institute 2022-08-15 Article PeerReviewed Barzegar Behrooz, Amir and Talaie, Zahra and Syahir, Amir (2022) Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable. Pharmaceutics, 14 (8). art. no. 1697. pp. 1-23. ISSN 1999-4923 https://www.mdpi.com/1999-4923/14/8/1697# 10.3390/pharmaceutics14081697
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Aggressive glioblastoma (GBM) has no known treatment as a primary brain tumor. Since the cancer is so heterogeneous, an immunosuppressive tumor microenvironment (TME) exists, and the blood–brain barrier (BBB) prevents chemotherapeutic chemicals from reaching the central nervous system (CNS), therapeutic success for GBM has been restricted. Drug delivery based on nanocarriers and nanotechnology has the potential to be a handy tool in the continuing effort to combat the challenges of treating GBM. There are various new therapies being tested to extend survival time. Maximizing therapeutic effectiveness necessitates using many treatment modalities at once. In the fight against GBM, combination treatments outperform individual ones. Combination therapies may be enhanced by using nanotechnology-based delivery techniques. Nano-chemotherapy, nano-chemotherapy–radiation, nano-chemotherapy–phototherapy, and nano-chemotherapy–immunotherapy for GBM are the focus of the current review to shed light on the current status of innovative designs.
format Article
author Barzegar Behrooz, Amir
Talaie, Zahra
Syahir, Amir
spellingShingle Barzegar Behrooz, Amir
Talaie, Zahra
Syahir, Amir
Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
author_facet Barzegar Behrooz, Amir
Talaie, Zahra
Syahir, Amir
author_sort Barzegar Behrooz, Amir
title Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
title_short Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
title_full Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
title_fullStr Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
title_full_unstemmed Nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
title_sort nanotechnology-based combinatorial anti-glioblastoma therapies: moving from terminal to treatable
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/102279/
https://www.mdpi.com/1999-4923/14/8/1697#
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score 13.211869

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