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Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review

Pesticides are known as potential mutagens as their ingredients may prompt mutations, alter chromosomes, and cause deoxyribonucleic acid (DNA) damage. Biomarker is a common tool used to assess health effects and exposure level. This paper reviewed studies from 2010 to 2020 on pesticides exposure and...

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Main Authors: Abd Rahman, Alia Azwa, Ho, Yu Bin, Nordin, Norshariza, Sin, Eugenie Sing Tan, Abdullah, Rozaini
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences 2022
Online Access:http://psasir.upm.edu.my/id/eprint/102183/1/2022041110264114_1056.pdf
http://psasir.upm.edu.my/id/eprint/102183/
https://medic.upm.edu.my/jurnal_kami/volume_18_2022/mjmhs_vol18_supp_5_april_2022-66369
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spelling my.upm.eprints.1021832023-08-11T08:23:18Z http://psasir.upm.edu.my/id/eprint/102183/ Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review Abd Rahman, Alia Azwa Ho, Yu Bin Nordin, Norshariza Sin, Eugenie Sing Tan Abdullah, Rozaini Pesticides are known as potential mutagens as their ingredients may prompt mutations, alter chromosomes, and cause deoxyribonucleic acid (DNA) damage. Biomarker is a common tool used to assess health effects and exposure level. This paper reviewed studies from 2010 to 2020 on pesticides exposure and DNA damage. Seven commonly used biomarkers were comet assay parameters, micronucleus (MN), nuclear buds (NBUD), nucleoplasmic bridges (NPB), 8-hydroxy-2-deoxyguanosine (8-OHdG), telomere length, and chromosomal aberrations (CA). The use of these biomarkers was evaluated with their advantages and disadvantages, as well as population exposed. Based on the findings, biomarkers have shown promising results as precursors of DNA damages. The associations between pesticide and DNA damage were equivocal, but most studies showed increment in genetic damages in exposed versus non-exposed population. These biomarkers can serve as predictive marker for risk of initiation and development of cancers or other chronic diseases. Faculty of Medicine and Health Sciences 2022 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/102183/1/2022041110264114_1056.pdf Abd Rahman, Alia Azwa and Ho, Yu Bin and Nordin, Norshariza and Sin, Eugenie Sing Tan and Abdullah, Rozaini (2022) Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review. Malaysian Journal of Medicine and Health Sciences, 18 (suppl.5). 120 - 125. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_18_2022/mjmhs_vol18_supp_5_april_2022-66369
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Pesticides are known as potential mutagens as their ingredients may prompt mutations, alter chromosomes, and cause deoxyribonucleic acid (DNA) damage. Biomarker is a common tool used to assess health effects and exposure level. This paper reviewed studies from 2010 to 2020 on pesticides exposure and DNA damage. Seven commonly used biomarkers were comet assay parameters, micronucleus (MN), nuclear buds (NBUD), nucleoplasmic bridges (NPB), 8-hydroxy-2-deoxyguanosine (8-OHdG), telomere length, and chromosomal aberrations (CA). The use of these biomarkers was evaluated with their advantages and disadvantages, as well as population exposed. Based on the findings, biomarkers have shown promising results as precursors of DNA damages. The associations between pesticide and DNA damage were equivocal, but most studies showed increment in genetic damages in exposed versus non-exposed population. These biomarkers can serve as predictive marker for risk of initiation and development of cancers or other chronic diseases.
format Article
author Abd Rahman, Alia Azwa
Ho, Yu Bin
Nordin, Norshariza
Sin, Eugenie Sing Tan
Abdullah, Rozaini
spellingShingle Abd Rahman, Alia Azwa
Ho, Yu Bin
Nordin, Norshariza
Sin, Eugenie Sing Tan
Abdullah, Rozaini
Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
author_facet Abd Rahman, Alia Azwa
Ho, Yu Bin
Nordin, Norshariza
Sin, Eugenie Sing Tan
Abdullah, Rozaini
author_sort Abd Rahman, Alia Azwa
title Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
title_short Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
title_full Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
title_fullStr Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
title_full_unstemmed Minimally invasive sampling sources for quality and quantity of DNA for telomere length measurement: a review
title_sort minimally invasive sampling sources for quality and quantity of dna for telomere length measurement: a review
publisher Faculty of Medicine and Health Sciences
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/102183/1/2022041110264114_1056.pdf
http://psasir.upm.edu.my/id/eprint/102183/
https://medic.upm.edu.my/jurnal_kami/volume_18_2022/mjmhs_vol18_supp_5_april_2022-66369
_version_ 1775624511547244544
score 13.211869

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