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Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae

Five compounds comprising of 8-O-4’-neolignan (7), two arylnaphthalene lignans (5, 8), aryldihydrobenzofuran neolignan (4), and lignan (6) were synthesised by enzymatic coupling reaction using horseradish peroxidase (HRP) between vanillin (1) with methyl ferulate (2) or methyl sinapate (3). All of t...

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Main Authors: Juhan, Siti Fadilah, Mohd Nor, Siti Mariam, Mat Ali, Mohd Shukri, Md Nor, Siti Zulaika
Format: Article
Published: University of Malaya 2023
Online Access:http://psasir.upm.edu.my/id/eprint/102077/
https://mjs.um.edu.my/index.php/MJS/article/view/38642
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spelling my.upm.eprints.1020772024-03-15T07:38:28Z http://psasir.upm.edu.my/id/eprint/102077/ Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae Juhan, Siti Fadilah Mohd Nor, Siti Mariam Mat Ali, Mohd Shukri Md Nor, Siti Zulaika Five compounds comprising of 8-O-4’-neolignan (7), two arylnaphthalene lignans (5, 8), aryldihydrobenzofuran neolignan (4), and lignan (6) were synthesised by enzymatic coupling reaction using horseradish peroxidase (HRP) between vanillin (1) with methyl ferulate (2) or methyl sinapate (3). All of these compounds, as well as previously synthesised palladium-catalysed coupling products of neolignan (9), 8-O-4'-neolignan (10), arylcoumarin (11), and lignan (12), were examined for larvicidal activityagainst Crocidolomia binotalis(C. binotalis)2ndinstar larvae. It was revealed that seven out of nine synthesised compounds had a mortality rate of more than 90% after 24 hours of exposure. Neolignan (10) and lignan (6) demonstrated strongest larvicidal activity with LD50 =2.218 mg/L and LD50 = 1.678 mg/L, respectively compared to the standard azadirachtin(LD50 =2.818 mg/L). The results showed that the synthesised compounds have a high potential for use in the control ofC. binotalislarvae and could be used in the development of new and more effective compounds as larvicides University of Malaya 2023 Article PeerReviewed Juhan, Siti Fadilah and Mohd Nor, Siti Mariam and Mat Ali, Mohd Shukri and Md Nor, Siti Zulaika (2023) Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae. Malaysian Journal of Science, 42 (1). pp. 7-16. ISSN 1394-3065; ESSN: 2600-8688 https://mjs.um.edu.my/index.php/MJS/article/view/38642 10.22452/mjs.vol42no1.2
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Five compounds comprising of 8-O-4’-neolignan (7), two arylnaphthalene lignans (5, 8), aryldihydrobenzofuran neolignan (4), and lignan (6) were synthesised by enzymatic coupling reaction using horseradish peroxidase (HRP) between vanillin (1) with methyl ferulate (2) or methyl sinapate (3). All of these compounds, as well as previously synthesised palladium-catalysed coupling products of neolignan (9), 8-O-4'-neolignan (10), arylcoumarin (11), and lignan (12), were examined for larvicidal activityagainst Crocidolomia binotalis(C. binotalis)2ndinstar larvae. It was revealed that seven out of nine synthesised compounds had a mortality rate of more than 90% after 24 hours of exposure. Neolignan (10) and lignan (6) demonstrated strongest larvicidal activity with LD50 =2.218 mg/L and LD50 = 1.678 mg/L, respectively compared to the standard azadirachtin(LD50 =2.818 mg/L). The results showed that the synthesised compounds have a high potential for use in the control ofC. binotalislarvae and could be used in the development of new and more effective compounds as larvicides
format Article
author Juhan, Siti Fadilah
Mohd Nor, Siti Mariam
Mat Ali, Mohd Shukri
Md Nor, Siti Zulaika
spellingShingle Juhan, Siti Fadilah
Mohd Nor, Siti Mariam
Mat Ali, Mohd Shukri
Md Nor, Siti Zulaika
Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae
author_facet Juhan, Siti Fadilah
Mohd Nor, Siti Mariam
Mat Ali, Mohd Shukri
Md Nor, Siti Zulaika
author_sort Juhan, Siti Fadilah
title Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae
title_short Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae
title_full Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae
title_fullStr Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae
title_full_unstemmed Larvicidal activity of the synthesised Lignans, neolignans, and coumarin against Crocidolimia binotalis 2nd instar larvae
title_sort larvicidal activity of the synthesised lignans, neolignans, and coumarin against crocidolimia binotalis 2nd instar larvae
publisher University of Malaya
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/102077/
https://mjs.um.edu.my/index.php/MJS/article/view/38642
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score 13.211869

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