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Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture

Fatty acid desaturase catalyzes the desaturation reactions by inserting double bonds into the fatty acyl chain, producing unsaturated fatty acids, which play a vital part in the synthesis of polyunsaturated fatty acids. Though soluble fatty acid desaturases have been described extensively in advance...

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Main Authors: Abd Halim, Nur Farah Anis, Mohamad Ali, Mohd Shukuri, Thean, Adam Chor Leow, Raja Abd Rahman, Raja Noor Zaliha
Format: Article
Published: Springer 2022
Online Access:http://psasir.upm.edu.my/id/eprint/101844/
https://link.springer.com/article/10.1007/s00253-022-12142-3
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spelling my.upm.eprints.1018442023-08-15T03:46:33Z http://psasir.upm.edu.my/id/eprint/101844/ Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture Abd Halim, Nur Farah Anis Mohamad Ali, Mohd Shukuri Thean, Adam Chor Leow Raja Abd Rahman, Raja Noor Zaliha Fatty acid desaturase catalyzes the desaturation reactions by inserting double bonds into the fatty acyl chain, producing unsaturated fatty acids, which play a vital part in the synthesis of polyunsaturated fatty acids. Though soluble fatty acid desaturases have been described extensively in advanced organisms, there are very limited studies of membrane fatty acid desaturases due to their difficulties in producing a sufficient amount of recombinant desaturases. However, the advancement of technology has shown substantial progress towards the development of elucidating crystal structures of membrane fatty acid desaturase, thus, allowing modification of structure to be manipulated. Understanding the structure, mechanism, and biosynthesis of fatty acid desaturase lay a foundation for the potential production of various strategies associated with alteration and modifications of polyunsaturated fatty acids. This manuscript presents the current state of knowledge and understanding about the structure, mechanisms, and biosynthesis of fatty acid desaturase. In addition, the role of unsaturated fatty acid desaturases in health and diseases is also encompassed. This will be useful in understanding the molecular basis and structural protein of fatty acid desaturase that are significant for the advancement of therapeutic strategies associated with the improvement of health status. Springer 2022-09-05 Article PeerReviewed Abd Halim, Nur Farah Anis and Mohamad Ali, Mohd Shukuri and Thean, Adam Chor Leow and Raja Abd Rahman, Raja Noor Zaliha (2022) Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture. Applied Microbiology and Biotechnology, 106 (18). pp. 5957-5972. ISSN 0175-7598; ESSN: 1432-0614 https://link.springer.com/article/10.1007/s00253-022-12142-3 10.1007/s00253-022-12142-3
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Fatty acid desaturase catalyzes the desaturation reactions by inserting double bonds into the fatty acyl chain, producing unsaturated fatty acids, which play a vital part in the synthesis of polyunsaturated fatty acids. Though soluble fatty acid desaturases have been described extensively in advanced organisms, there are very limited studies of membrane fatty acid desaturases due to their difficulties in producing a sufficient amount of recombinant desaturases. However, the advancement of technology has shown substantial progress towards the development of elucidating crystal structures of membrane fatty acid desaturase, thus, allowing modification of structure to be manipulated. Understanding the structure, mechanism, and biosynthesis of fatty acid desaturase lay a foundation for the potential production of various strategies associated with alteration and modifications of polyunsaturated fatty acids. This manuscript presents the current state of knowledge and understanding about the structure, mechanisms, and biosynthesis of fatty acid desaturase. In addition, the role of unsaturated fatty acid desaturases in health and diseases is also encompassed. This will be useful in understanding the molecular basis and structural protein of fatty acid desaturase that are significant for the advancement of therapeutic strategies associated with the improvement of health status.
format Article
author Abd Halim, Nur Farah Anis
Mohamad Ali, Mohd Shukuri
Thean, Adam Chor Leow
Raja Abd Rahman, Raja Noor Zaliha
spellingShingle Abd Halim, Nur Farah Anis
Mohamad Ali, Mohd Shukuri
Thean, Adam Chor Leow
Raja Abd Rahman, Raja Noor Zaliha
Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
author_facet Abd Halim, Nur Farah Anis
Mohamad Ali, Mohd Shukuri
Thean, Adam Chor Leow
Raja Abd Rahman, Raja Noor Zaliha
author_sort Abd Halim, Nur Farah Anis
title Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
title_short Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
title_full Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
title_fullStr Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
title_full_unstemmed Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
title_sort membrane fatty acid desaturase: biosynthesis, mechanism, and architecture
publisher Springer
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/101844/
https://link.springer.com/article/10.1007/s00253-022-12142-3
_version_ 1775624500465893376
score 13.211869

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